SUZANA MATAYOSHI
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Otorrinolaringologia e Oftalmologia, Faculdade de Medicina - Docente
LIM/33 - Laboratório de Oftalmologia, Hospital das Clínicas, Faculdade de Medicina
LIM/33 - Laboratório de Oftalmologia, Hospital das Clínicas, Faculdade de Medicina
6 resultados
Resultados de Busca
Agora exibindo 1 - 6 de 6
- Reconstrução total de pálpebra superior no tratamento do carcinoma de glândula sebácea(2020) VERAS, Deborah de Oliveira; GUMIERO, Mariana Pereira Leite Dias; BAPTISTA, Mariana Nóbrega Meireles; MATAYOSHI, SuzanaAbstract Sebaceous gland carcinoma (SGC) is the third most frequent malignant neoplasm in the eyelids. It usually affects elderly women and can simulate blepharitis or chalazion. Upper eyelid reconstruction is always challenging. The purpose of this is to report an unusual case of SGC in the upper eyelid of a young and male patient. Total resection of the right upper eyelid was performed and histological examination revealed free margins. The reconstruction was done with two surgical procedures at different times. Due to the fact that SGC presents a high potential for metastasis, the patient continues to be followed for functional and aesthetic reevaluation.
- Invasive squamous cell carcinomas and precursor lesions on UV-exposed epithelia demonstrate concordant genomic complexity in driver genes(2020) VEGA, Lorena Lazo de la; BICK, Nolan; HU, Kevin; RAHRIG, Samantha E.; SILVA, Camilla Duarte; MATAYOSHI, Suzana; PICCIARELLI, Patricia; WANG, Xiaoming; SUGAR, Alan; SOONG, Hunson Kaz; MIAN, Shahzad I.; ROBINSON, Dan R.; CHINNAIYAN, Arul M.; DEMIRCI, Hakan; DANIELS, Anthony B.; WORDEN, Francis; EBERHART, Charles G.; TOMLINS, Scott A.; RAO, Rajesh C.; HARMS, Paul W.Although squamous cell carcinomas (SCC) are the most frequent human solid tumor at many anatomic sites, the driving molecular alterations underlying their progression from precursor lesions are poorly understood, especially in the context of photodamage. Therefore, we used high-depth, targeted next-generation sequencing (NGS) of RNA and DNA from routine tissue samples to characterize the progression of both well- (cutaneous) and poorly (ocular) studied SCCs. We assessed 56 formalin-fixed paraffin-embedded (FFPE) cutaneous lesions (n = 8 actinic keratosis,n = 30 carcinoma in situ [CIS],n = 18 invasive) and 43 FFPE ocular surface lesions (n = 2 conjunctival/corneal intraepithelial neoplasia,n = 20 CIS,n = 21 invasive), from institutions in the US and Brazil. An additional seven cases of advanced cutaneous SCC were profiled by hybrid capture-based NGS of >1500 genes. The cutaneous and ocular squamous neoplasms displayed a predominance of UV-signature mutations. Precursor lesions had highly similar somatic genomic landscapes to SCCs, including chromosomal gains of 3q involvingSOX2, and highly recurrent mutations and/or loss of heterozygosity events affecting tumor suppressorsTP53andCDKN2A. Additionally, we identify a novel molecular subclass of CIS withRB1mutations. AmongTP53wild-type tumors, human papillomavirus transcript was detected in one matched pair of cutaneous CIS and SCC. Amplicon-based whole-transcriptome sequencing of select 20 cutaneous lesions demonstrated significant upregulation of pro-invasion genes in cutaneous SCCs relative to precursors, includingMMP1,MMP3,MMP9,LAMC2,LGALS1, andTNFRSF12A. Together, ocular and cutaneous squamous neoplasms demonstrate similar alterations, supporting a common model for neoplasia in UV-exposed epithelia. Treatment modalities useful for cutaneous SCC may also be effective in ocular SCC given the genetic similarity between these tumor types. Importantly, in both systems, precursor lesions possess the full complement of major genetic changes seen in SCC, supporting non-genetic drivers of invasiveness.
- Conical Biosilicate Implant for Volume Augmentation in Anophthalmic Sockets(2020) BRANDAO, Simone Milani; SCHELLINI, Rodolfo Artioli; PEITL, Oscar; ZANOTTO, Edgar Dutra; MATAYOSHI, Suzana; MENEGHIM, Roberta Lilian Fernandes de Sousa; SCHELLINI, Silvana ArtioliThe ideal implant for anophthalmic socket reconstruction has yet to be developed. Biosilicate, a highly bioactive glass-ceramic, has been used in the composition of conical implants, which were initially tested in rabbit orbits with excellent results. However, the use of this material and the conical shape of the implants require further study in the human anophthalmic socket. Thus, we propose the use of a new conical implant composed of Biosilicate for orbital volume augmentation in anophthalmic sockets. This prospective, randomized study included 45 patients receiving conical implants composed of either Biosilicate or polymethylmethacrylate (control). Patients were evaluated clinically before and 7, 30, 60, 120, and 180 days after implantation. Systemic evaluations, laboratory tests, and computed tomography of the orbits were performed preoperatively and 180 days postoperatively. Both groups had good outcomes with no significant infectious or inflammatory processes. Only 1 patient, in the Biosilicate group, had early implant extrusion. Laboratory tests were normal in both groups. Computed tomography scans showed that the implants in both groups were well positioned. The new conical implant composed of Biosilicate was successfully used for anophthalmic socket reconstruction. This implant may provide a good alternative to the only conical implant currently available on the market, which is composed of porous polyethylene.
- Fogo em campo cirúrgico - Medidas preventivas para cirurgia palpebral segura(2020) STUCHI, Daniella de Paiva Almeida; CHEBLE, Camila; MATAYOSHI, SuzanaAbstract Fire in the surgical field during eyelid surgery is an intra-operative complication that is dramatic for both the patient and the medical staff. It’s being reported a case of surgical accident during eyelid surgery where the patient suffered a brow burn. There was interaction between the oxygen used for sedation (open mask) and a source of ignition represented by monopolar cautery. Although the patient presented good clinical evolution with complete recovery of the cutaneous lesion, this case is an alert to avoid such type of occurrence. This work highlights the conditions involved and the way of prevention.
- Reliability of endoscopic dye transit test for prediction of functional success after diode laser and external dacryocystorhinostomy(2020) FEIJO, Eduardo Damous; CAIXETA, Juliana Alves; ALMEIDA, Adriana Ribeiro de; LIMONGI, Roberto Murillo; MATAYOSHI, SuzanaPurpose: To determine the reliability of the endoscopic dye transit test for the prediction of functional success after dacryocystorhinostomy. Methods: A cross-sectional study was conducted with 50 patients who underwent external dacryocystorhinostomy Group or transcanalicular dacryocystorhinostomy Group and had anatomically patent ducts during irrigation, with a minimum 6-month follow-up. The external dacryocystorhinostomy, defined as the time from instillation of the dye into the conjunctival sac until its flow from the rhinostomy site, was performed in all patients. Positive predictive value of the endoscopic dye transit test to assess functional success was analyzed. The cutoff point was determined using a receiver operating characteristic curve. Results: Of the 50 patients, 44 (88%) exhibited subjective improvement or complete resolution of epiphora (functional success). The best cutoff point for the endoscopic dye transit test was 60 s. Of 39 patients with endoscopic dye transit test <= 60 s, 38 (97.4%) exhibited functional success, demonstrating a 97.4% positive predictive value. Conclusion: The endoscopic dye transit test <= 60 s is a reliable tool to predict functional success and good prognosis after external or laser transcanalicular dacryocystorhinostomy.
- Giant Bilateral Cysts of the Accessory Lacrimal Glands of Wolfring in a Child(2020) FEIJO, Eduardo Damous; LANDIM, George Alencastro; DIAS, Mirna de Melo; SOUZA, Bruna Angelina Alves de; LIMONGI, Roberto Murillo; MATAYOSHI, SuzanaDuctal cysts of the accessory lacrimal glands of Wolfring are rare clinical entities. They typically present as mobile and translucent lesions on the superior or inferior tarsal borders. Here, the authors describe a 7-year-old male child presenting with giant bilateral cysts of Wolfring. Management of such cysts is primarily surgical and the preferred route for excision is transconjunctival. To the best of the authors' knowledge, this is the first report of a bilateral Wolfring dacryops affecting a child.