PAULO HENRIQUE BRAZ DA SILVA
Projetos de Pesquisa
Unidades Organizacionais
ODE, FO - Docente
LIM/52 - Laboratório de Virologia, Hospital das Clínicas, Faculdade de Medicina
LIM/52 - Laboratório de Virologia, Hospital das Clínicas, Faculdade de Medicina
5 resultados
Resultados de Busca
Agora exibindo 1 - 5 de 5
- SARS-CoV-2 and dentistry(2020) ORTEGA, Karem L.; CAMARGO, Alessandra Rodrigues de; FRANCO, Juliana Bertoldi; AZUL, Antonio Mano; SAYANS, Mario Perez; SILVA, Paulo Henrique Braz
- Do hydrogen peroxide mouthwashes have a virucidal effect? A systematic review(2020) ORTEGA, K. L.; RECH, B. O.; HAJE, G. L. C. El; GALLO, C. B.; PEREZ-SAYANS, M.; BRAZ-SILVA, P. H.Background: The presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) in saliva has alerted health professionals to the possibility of contamination by aerosols generated in a number of procedures. The indication of preoperative mouthwash containing 1% hydrogen peroxide for reducing the viral load of SARS-CoV-2 in saliva prior to oral procedures has been significantly disseminated through several citations and influenced various dental associations in the elaboration of dental care protocols during this pandemic period, including patients admitted to hospital wards and intensive care units. Aim: To Our aim was to perform a systematic review to answer the following question: does hydrogen peroxide mouthwash (at any concentration) have a virucidal effect? Methods: The Cochrane, LILACS, PubMed, Scopus, and Embase databases were searched by using the following key-words: 'hydrogen peroxide', 'mouthwash', 'mouth rinse', 'rinse', 'oral rinse', 'mouth bath', 'mouth wash', and 'mouth washes'. Reviews, letters to the editor, personal opinions, book chapters, case reports, congress abstracts, studies with animals and studies on mouthwash containing other compounds other than hydrogen peroxide were excluded. Findings: During the initial search 1342 articles were identified on the five electronic databases. After excluding some duplicates, 976 articles remained. Only studies assessing the virucidal effect of hydrogen peroxide mouthwash were selected, regardless of publication date. Conclusion: After reading titles and abstracts, no article met the eligibility criteria. In conclusion, there is no scientific evidence supporting the indication of hydrogen peroxide mouthwash for control of the viral load regarding SARS-CoV-2 or any other viruses in saliva.
- Is 0.5% hydrogen peroxide effective against SARS-CoV-2?(2022) ORTEGA, Karem Lopez; RECH, Bruna de Oliveira; COSTA, Andre Luiz Ferreira; SAYANS, Mario Perez; BRAZ-SILVA, Paulo Henrique
- Quantification of Torque Teno Virus (TTV) in plasma and saliva of individuals with liver cirrhosis: a cross sectional study(2023) LUCA, Ana Clara Falabello de; MARINHO, Gabriella Bueno; FRANCO, Juliana Bertoldi; TENORIO, Jefferson da Rocha; ANDRADE, Natalia Silva; BATISTA, Alexandre Mendes; MAMANA, Ana Carolina; TOZETTO-MENDOZA, Tania Regina; SAYANS, Mario Perez; BRAZ-SILVA, Paulo Henrique; ORTEGA, Karem L.Introduction: Torque teno virus ( TTV) has been pointed as an endogenous marker of immune function, the objective of this study was to investigate the TTV viral load in plasma and saliva of cirrhotic individuals and correlate it with clinical characteristics. Methods: Blood, saliva, clinical data from records and laboratory tests were collected from 72 cirrhotic patients. Plasma and saliva were submitted to realtime polymerase chain reaction for quantification of TTV viral load. Results: The majority of the patients presented decompensated cirrhosis (59.7%) and 47.2% had alterations in the white blood series. TTV was identified in 28 specimens of plasma (38.8%) and in 67 specimens of saliva (93.0%), with median values of TTV copies/mL of 90.6 in plasma and 245.14 in saliva. All the patients who were positive for TTV in plasma were also positive in saliva, with both fluids having a moderately positive correlation for the presence of TTV. There was no correlation between TTV viral load, either in plasma or in saliva, and any of the variables studied. Conclusion: TTV is more frequently found and in greater amount in the saliva than in the plasma of cirrhotic patients. There was no correlation between TTV viral load and clinical parameters.
- Can ""COVID-19 tongue"" be considered a pathognomonic finding in SARS-CoV-2 infection?(2022) PEREZ-SAYANS, Mario; ORTEGA, Karem L.; BRAZ-SILVA, Paulo Henrique; CARRERAS-PRESAS, Carmen Martin; CARRION, Andres Blanco