GUILHERME JACOM ABDULMASSIH WOOD
Projetos de Pesquisa
Unidades Organizacionais
LIM/55 - Laboratório de Urologia, Hospital das Clínicas, Faculdade de Medicina
4 resultados
Resultados de Busca
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- Diagnostic accuracy of physical examination compared with color Doppler ultrasound in the determination of varicocele diagnosis and grading: Impact of urologists' experience(2020) COCUZZA, Marcello S.; TISEO, Bruno C.; SROUGI, Victor; WOOD, Guilherme J. A.; CARDOSO, Joao P. G. F.; ESTEVES, Sandro C.; SROUGI, MiguelBackground Treatment of palpable varicocele in infertile men with abnormal semen parameters is widely accepted, and physical examination (PE) remains a cornerstone for recommending varicocele repair. However, identification of clinical varicocele during PE can be challenging for both urology residents and consultants. Objective To compare the diagnostic accuracy of PE to color Doppler ultrasonography (CDU) for the diagnosis of varicocele in experienced and non-experienced examiners. Materials and methods Diagnostic accuracy study involving 78 patients attending a university-based infertility unit. Patients underwent scrotal PE by both experienced (over 10 years experience in male infertility) and non-experienced urologists (senior residents), and were subjected to CDU. varicocele diagnosis and varicocele grading were compared between examiner groups and to CDU. Accuracy measures were evaluated, and interobserver agreement was estimated using unweighted kappa statistics. A subgroup analysis for normal and high body mass index (BMI) was also performed for the same variables. Results Accuracy of PE for varicocele diagnosis was 63.5% with a positive predictive value (PPV) of 75.5%. The specificity and PPV of PE were higher among experienced than non-experienced urologists (82.0% CI: 74.27-88.26 and 81.1% CI: 74.39-86.44% vs 67.2% CI: 58.33-75.22 and 70.6% CI: 64.52-76.08, respectively). Agreements on varicocele diagnosis (k: 0.625 vs 0.517) and grading (k: 0.548 vs 0.418) by PE were higher among experienced than non-experienced urologists. Differences between eutrophic and overweight/obese patients were also suggested. Discussion and conclusions PE performed by infertility specialists identify patients with varicocele more precisely than non-specialists. However, PE alone has suboptimal accuracy for varicocele diagnosis. Our results indicate that PE should be followed by CDU to decrease the number of false positives and increase the diagnostic accuracy of varicocele diagnosis.
- Varicocele-Associated Infertility and the Role of Oxidative Stress on Sperm DNA Fragmentation(2021) WOOD, Guilherme Jacom Abdulmassih; CARDOSO, Joao Paulo Greco; PALUELLO, Davi Vischi; NUNES, Thiago Fagundes; COCUZZA, MarcelloVaricocele has been extensively described and studied as the most important reversible cause of male infertility. Its impact on semen parameters, pregnancy rates, and assisted reproductive outcomes have been associated with multifactorial aspects, most of them converging to increase of reactive oxygen species (ROS). More recently, sperm DNA fragmentation has gained significant attention and potential clinical use, although the body of evidence still needs further evolution. The associations between sperm DNA damage and a variety of disorders, including varicocele itself, share common pathways to ROS increase. This mini-review discusses different aspects related to the etiology of ROS and its relation to varicocele and potential mechanisms of DNA damage.
conferenceObject Impact of obesity and bariatric surgery on erectile function, reproductive hormones, testicular function, and sperm DNA fragmentation(2019) WOOD, G.; TISEO, B.; CARDOSO, J. P.; MARTIN, H. De; FRANCHIM, C.; SANTO, M. A.; SROUGI, M.; NAHAS, W.; COCUZZA, M. A.conferenceObject BARIATRIC SURGERY IMPACT ON ERECTILE FUNCTION, SEMEN PARAMETERS AND SEXUAL HORMONES IN OBESE MEN(2019) WOOD, Guilherme; TISEO, Bruno; CARDOSO, Joao Paulo; MARTIN, Hamilton de; SANTO, Marco Aurelio; SROUGI, Miguel; COCUZZA, Marcello Antonio