KARIN CARNEIRO DE OLIVEIRA

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LIM/16 - Laboratório de Fisiopatologia Renal, Hospital das Clínicas, Faculdade de Medicina

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Autor e Coautores FMUSP-HC Normalizados: FLAVIA RAMOS DE SIQUEIRA ×

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  • bookPart 0 Citação(ões) na Scopus
    Impact of low-salt diet
    (2019) SIQUEIRA, F. R. De; OLIVEIRA, K. C. De; HEIMANN, J. C.; FURUKAWA, L. N. S.
    Studies in experimental animals and in groups of humans and epidemiological studies have shown that the sodium chloride or salt (sodium, Na, NaCl) plays an important role mainly in the regulation of blood pressure and represents an important environmental factor involved in the genesis of cardiovascular diseases. Therefore, salt intake in the population has been a constant concern. Variable blood pressure responses to different content in sodium intake are found in experimental hypertension models and in humans, and the reasons for such heterogeneity are not fully elucidated. The reduction of dietary sodium intake is recommended by public health as one of the non-medicated treatments for hypertension and consequently reducing the risk of cardiovascular diseases. However, some studies have demonstrated side effects of salt dietary restriction, reporting changes in glucose metabolism (hyperinsulinemia and insulin resistance), and these alterations are gender and time specific in experimental and population studies. © Springer Nature Switzerland AG 2019.
  • article 7 Citação(ões) na Scopus
    Effect of parathyroidectomy on bone tissue biomarkers and body composition in patients with chronic kidney disease and secondary hyperparathyroidism
    (2021) SIQUEIRA, Flavia Ramos de; OLIVEIRA, Karin Carneiro de; DOMINGUEZ, Wagner Vasques; TRUYTS, Cesar Augusto Madid; MOYSES, Rosa Maria Affonso; REIS, Luciene Machado dos; JORGETTI, Vanda
    Background/objective Loss of renal function may induce secondary hyperparathyroidism (s-HPT), which triggers several complications leading to an extreme decline in quality of life and increased mortality in affected patients. We evaluated whether parathyroidectomy (PTx), as surgical treatment for s-HPT, modifies body composition, and hormones involved in the protein-energy metabolism of affected patients. Subjects/methods Overall, 30 s-HPT patients were evaluated at two times, before PTx (pre PTx) and 6 months after PTx (post PTx). Patients were evaluated by biochemistry analysis, anthropometry, electrical bioimpedance (BIA), food intake diary, handgrip strength, and modified global subjective nutritional assessment (SGA). Results After PTx, patients showed decreased serum levels of total and ionic calcium, as well as decreased alkaline phosphatase and PTH, and increased 25 (OH) vitamin D. These results demonstrate that PTx was efficient to correct part of the mineral disorder. We also observed an increase in caloric intake, body weight, body mass index (BMI), phase angle, handgrip strength, SGA score, and a decreasing in the percentage of weight loss. The osteocalcin concentration of both carboxylated (cOC) and undercarboxylated form was diminished post PTx. The cOC correlated with bone metabolism markers and SGA score. Conclusions PTx modified body composition improving nutritional status and preventing the progression of weight loss with increased of energy intake, BMI, handgrip strength, phase angle of BIA, and SGA score. The present study also suggests an association of cOC with bone markers and SGA score. Further studies are needed to better clarify these associations with larger sample size.