THIAGO PASQUALIN

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Instituto de Ortopedia e Traumatologia, Hospital das Clínicas, Faculdade de Medicina - Médico

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  • conferenceObject
    Joint lavage followed by viscosuplementation and triamcinolone in patients with severe hemophilic arthropathy. Objective functional results
    (2015) PASQUALIN, T.; REZENDE, M. U. D.; ANDRUSAITIS, F. R.; CAMPOS, G. C. D.; FRUCCHI, R.; PAILO, A. F.; OKAZAKI, E.; VILLACA, P. R.
  • conferenceObject
    EVALUATION OF THE EFFECT OF ADDING CORTICOSTEROID TO VISCOSUPPLEMENTATION: A PROSPECTIVE AND RANDOMIZED STUDY
    (2012) CAMPOS, G. C.; REZENDE, M. U.; PAILO, A. F.; FRUCCHI, R.; PASQUALIN, T.
    Purpose: The aim of this study is to assess if we can improve the initial results of viscosupplementation by the addition of corticosteroids to the procedure, watching for any interference on the long-term results. Methods: We evaluated 104 patients with knee osteoarthritis (OA), treated at the group for the treatment of osteometabolic diseases of IOT-FMUSP, São Paulo. All patients were receiving usual care for OA, and those who underwent to any kind of intraarticular injection or knee surgery in the last 6 months, or presented post-traumatic or rheumatoid arthritis were not included into the protocol. We applied the visual analogic scale of pain (VAS) and the algofunctional questionnaires WOMAC and Lequesne. Patients were randomized into two groups of 52 patients each. Group 1 received a single intraarticular injection of the knee with 6ml of Synvisc One (Hylan GF-20) alone. Patients in group 2 received an intraarticular injection of the knee with 6ml of Synvisc One (Hylan GF-20) and 1ml (20mg) of Hexacetonide Triamcinolone. The questionnaires were applied prior to the injection (week zero) and at weeks 1, 4, 12 and 24 after the procedure. This study was aproved by the University of São Paulo Clinics Hospital's ethics committee and entirely funded by FAPESP (Cientific research support foundation) - Grant number 2010/11450-9. It can be accessed at clinicaltrials.com. Results: The patient's characteristics of the two groups were compared with chi-square and Fisher's exact tests and were considered homogeneus. Most patiens were female (76%). The mean age was 62,7 years old. The average BMI of patients was 29.52. Most patients (34,6%) had a level 3 Kellgreen and Lawrence radiological classification for knee OA. The pre-injection scores were: Group 1- WOMAC = 50,21 (SD = 16,15); VAS = 67,27 (SD = 20,08); Lequesne = 13.24 (SD = 3,85). Group 2- WOMAC = 54,54 (SD = 17,58); VAS = 70,21 (SD = 23,59); Lequesne = 13.86 (SD = 4,18). These results were statistically compared and there was no statistic difference between groups. At Week 1, Group 2 showed a marked reduction for WOMAC and VAS scores, with a statistically significant difference compared with week zero and also when compared with Group 1 week one results. At week 4, group 2 still had better results for WOMAC and VAS compared to group 1, but with a p>0,05. The WOMAC and VAS results for weeks 12 and 24 were similar within the 2 groups. The Lequesne results had no statistically significant difference between the 2 groups at any moment. However, each group had a statistically significant improvement at weeks 1, 4, 12 and 24 compared to the baseline. Results are shown in tables and graphics below: None of the individuals characteristics such as age, genre, BMI or Kellgreen and Lawrence classification had any effects on the results. Adverse effects were: 4,8% of the patients presented effusion and 19,2% of the patients related discomfort or pain. There was no statistic difference between the groups. Conclusion: We concluded that the addition of 1ml of triancinolone to viscosupplementation brings great improvement to its early results and does not affect the long-term results, so it should be performed.
  • conferenceObject
    EVALUATION OF THE EFFECT OF ADDING CORTICOSTEROID TO VISCOSUPPLEMENTATION: A PROSPECTIVE AND RANDOMIZED STUDY
    (2012) REZENDE, Marcia U.; CAMPOS, Gustavo C.; PAILO, Alexandre F.; FRUCCHI, Renato; PASQUALIM, Thiago
    Objective(s): The objective is to assess if we can improve the initial results of viscosupplementation by the addition of corticosteroids to the procedure, watching for any interference on the long-term results Material & Methods: We evaluated 104 patients with knee osteoarthritis (OA).All patients were receiving usual care, and those who underwent to intraarticular injection or knee surgery in the last 6 months, or had post-traumatic or rheumatoid arthritis were not included. We applied the visual analogic scale of pain (VAS) and WOMAC and Lequesne questionnaires. Patients were randomized into two groups of 52 patients each. Group 1 received a single intraarticular injection of theknee with 6 ml of Hylan GF-20 alone. Patients in group 2 received an intraarticular injection of the knee with 6 ml of Hylan GF-20 and 1 ml (20 mg) of hexacetonide triamcinolone. The questionnaires were applied prior to the injection (week zero) and at weeks 1, 4, 12 and 24 after the procedure. Results: The two groups were homogenous. Most patients were female (76%). The mean age was 62,7 years old. The average BMI of patients was 29.52. Most patients (34.6%) had a level 3 Kellgreen and Lawrence radiological classification for knee OA. At Week 1, Group 2 showed a marked reduction for WOMAC and VAS scores, with a statistically significant difference compared with Group 1 results. At week 4, group 2 still had better results for WOMAC and VAS compared to group 1, but with a p>0.05. The WOMAC and VAS results for weeks 12 and 24 were similar within the 2 groups. The Lequesne results had no statistically significant difference between the 2 groups at any moment. However, each group had a statistically significant improvement at weeks 1, 4, 12 and 24 compared to the baseline. None of the individuals characteristics such as age, genre, BMI or K&L classification had any effects on the results. Adverse effects: 4.8% presented effusion and 19.2% related discomfort or pain, with no statistic difference between groups. Conclusion(s): We concluded that the addition of 1 ml of triancinolone to viscosupplementation brings great improvement to its early results and does not affect the long-term results, so it should be performed.
  • article
    Adding triamcinolone to viscosupplementation: one year outcome of randomized trial
    (2014) CAMPOS, Gustavo Constantino; HISSADOMI, Marcelo Issao; FRUCCHI, Renato; PASQUALIN, Thiago; REZENDE, Marcia Uchôa de
    OBJECTIVE: This is an extended follow-up of a randomized controlled trial to evaluate if the addition of triamcinolone to viscosupplementation could alter one-year pain and function of viscosupplementation alone. This is a Level I Therapeutic study (See Guidelines for Authors for a complete description of levels of evidence). METHODS: In a previously reported study we prospectively enrolled 104 patients with knee osteoarthritis and randomized them to receive either a single intra-articular injection (6 mL) of hylan GF-20 (Group viscosupplementation [Group VS]), or a single intra-articular injection of hylan GF-20 (6 mL) and 1 mL (20 mg) of triamcinolone hexacetonide (Group VS + T). Visual Analogue Scale, WOMACTM, and Lequesne questionnaires were completed at baseline, at weeks 1, 4, 12, 24. At the one-year follow-up point, all patients were recruited and reassessed. RESULTS: At one year, the effects of treatment observed in the previous periods were present, with no differences between groups; only the Group receiving hylan + triamcinolone hexacetonide still showed a difference from baseline in the Visual Analogue Scale questionnaire. CONCLUSIONS: The addition of triamcinolone hexacetonide improves first-week symptoms and functional scores of viscosupplementation and does not alter its adverse effects. There might be benefits for the one-year pain results.
  • conferenceObject
    Joint Lavage Followed by Viscosuplementation and Triamcinolone in Patients With Severe Hemophilic Arthropathy: Subjective Pain, Function and Quality of Life Results
    (2015) REZENDE, M.; PASQUALIN, T.; CAMPOS, G.; FRUCCHI, R.; PAILO, A.; ROSA, T.; OKAZAKI, E.; VILACA, P.
  • conferenceObject
    BMI, OBESITY AND EDUCATION
    (2014) BRITO, N. L.; REZENDE, M. U.; HISSADOMI, M. I.; PAILO, A. F.; PASQUALIN, T.; CAMPOS, G. C.; FRUCCHI, R.
  • conferenceObject
    PARQVE: PROJECT ARHTRITIS RECOVERING QUALITY OF LIFE BY MEANS OF EDUCATION
    (2013) REZENDE, Marcia; CAMPOS, Gustavo; PAILO, Alexandre; FRUCCHI, Renato; PASQUALIN, Thiago; HISSADOMI, Marcelo
  • article 4 Citação(ões) na Scopus
    Study on implant stability in cementless total knee arthroplasty
    (2012) TIRICO, Luis Eduardo Passarelli; PASQUALIN, Thiago; PECORA, Jose Otavio; GOBBI, Riccardo Gomes; PECORA, Jose Ricardo; DEMANGE, Marco Kawamura
    Objetives: Determine the stability of tibial and femoral components of 20 cementless knee arthroplasties with rotating platform. Methods: The 20 patients (20 knees) underwent an analysis of dynamic radiographs with an image amplifier and maneuvers of varus and valgus which were compared to static frontal and lateral radiographs of the knees and analyzed by two experienced surgeons in a double-blind way. Results: We could observe in this study that both methods showed very similar results for the stability of the tibial and femoral components (p<0.001) using the Kappa method for comparison. Conclusion: The tibial component was more unstable in relation to the femoral component in both static and dynamic studies. Level of Evidence IV, Case Series.
  • article 10 Citação(ões) na Scopus
    PARQVE: PROJECT ARTHRITIS RECOVERING QUALITY OF LIFE THROUGH EDUCATION: TWO-YEAR RESULTS
    (2017) REZENDE, Marcia Uchoa de; FRUCCHI, Renato; PAILO, Alexandre Felicio; CAMPOS, Gustavo Constantino de; PASQUALIN, Thiago; HISSADOMI, Marcelo Issao
    Objective: To evaluate the effects of a multi-professional educational program in patients with knee osteoarthritis (KOA). Methods: Prospective randomized controlled trial with 195 KOA patients. One group was submitted to two-day lectures and received educational material about KOA (Class group), and the control group received the educational material only. Patients were evaluated at baseline, twelve and 24 months. At evaluation, patients answered pain and functional questionnaires (WOMAC, Lequesne, VAS and SF-36); reported the intensity of exercise per week; measured the body fat percentage, weight and height to estimate body mass index (BMI); and performed Timed Up & Go (TUG) and Five-Times-Sit-to- Stand (FTSST) tests. Results: The groups presented similar results in all time points with respect to pain (VAS and WOMAC pain), WOMAC, BMI and body fat percentage (p>0.05). The Class group exhibited improved function according to the Lequesne questionnaire, whereas the control group worsened (p=0.02) during follow-up (p<0.02). TUG (p=0.01) and FTSST (p<0.001) improved in the Class group. A higher percentage of patients in the Class group performed regular physical activity (p=0.045). Conclusions: The educational program with classes improved the consistency of physical activity and the subjective and objective function of patients with KOA.
  • conferenceObject
    ADDING TRIAMCINOLONE TO VISCOSUPPLEMENTATION: ONE YEAR OUTCOME OF RANDOMIZED TRIAL
    (2014) CAMPOS, G. C.; REZENDE, M. U.; FRUCHI, R.; PASQUALIN, T.; HISSADOMI, M. I.