THIAGO PASQUALIN
Índice h a partir de 2011
5
Projetos de Pesquisa
Unidades Organizacionais
Instituto de Ortopedia e Traumatologia, Hospital das Clínicas, Faculdade de Medicina - Médico
13 resultados
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conferenceObject EVALUATION OF THE EFFECT OF ADDING CORTICOSTEROID TO VISCOSUPPLEMENTATION: A PROSPECTIVE AND RANDOMIZED STUDY(2012) CAMPOS, G. C.; REZENDE, M. U.; PAILO, A. F.; FRUCCHI, R.; PASQUALIN, T.Purpose: The aim of this study is to assess if we can improve the initial results of viscosupplementation by the addition of corticosteroids to the procedure, watching for any interference on the long-term results. Methods: We evaluated 104 patients with knee osteoarthritis (OA), treated at the group for the treatment of osteometabolic diseases of IOT-FMUSP, São Paulo. All patients were receiving usual care for OA, and those who underwent to any kind of intraarticular injection or knee surgery in the last 6 months, or presented post-traumatic or rheumatoid arthritis were not included into the protocol. We applied the visual analogic scale of pain (VAS) and the algofunctional questionnaires WOMAC and Lequesne. Patients were randomized into two groups of 52 patients each. Group 1 received a single intraarticular injection of the knee with 6ml of Synvisc One (Hylan GF-20) alone. Patients in group 2 received an intraarticular injection of the knee with 6ml of Synvisc One (Hylan GF-20) and 1ml (20mg) of Hexacetonide Triamcinolone. The questionnaires were applied prior to the injection (week zero) and at weeks 1, 4, 12 and 24 after the procedure. This study was aproved by the University of São Paulo Clinics Hospital's ethics committee and entirely funded by FAPESP (Cientific research support foundation) - Grant number 2010/11450-9. It can be accessed at clinicaltrials.com. Results: The patient's characteristics of the two groups were compared with chi-square and Fisher's exact tests and were considered homogeneus. Most patiens were female (76%). The mean age was 62,7 years old. The average BMI of patients was 29.52. Most patients (34,6%) had a level 3 Kellgreen and Lawrence radiological classification for knee OA. The pre-injection scores were: Group 1- WOMAC = 50,21 (SD = 16,15); VAS = 67,27 (SD = 20,08); Lequesne = 13.24 (SD = 3,85). Group 2- WOMAC = 54,54 (SD = 17,58); VAS = 70,21 (SD = 23,59); Lequesne = 13.86 (SD = 4,18). These results were statistically compared and there was no statistic difference between groups. At Week 1, Group 2 showed a marked reduction for WOMAC and VAS scores, with a statistically significant difference compared with week zero and also when compared with Group 1 week one results. At week 4, group 2 still had better results for WOMAC and VAS compared to group 1, but with a p>0,05. The WOMAC and VAS results for weeks 12 and 24 were similar within the 2 groups. The Lequesne results had no statistically significant difference between the 2 groups at any moment. However, each group had a statistically significant improvement at weeks 1, 4, 12 and 24 compared to the baseline. Results are shown in tables and graphics below: None of the individuals characteristics such as age, genre, BMI or Kellgreen and Lawrence classification had any effects on the results. Adverse effects were: 4,8% of the patients presented effusion and 19,2% of the patients related discomfort or pain. There was no statistic difference between the groups. Conclusion: We concluded that the addition of 1ml of triancinolone to viscosupplementation brings great improvement to its early results and does not affect the long-term results, so it should be performed.- BMI, OBESITY AND EDUCATION(2014) BRITO, N. L.; REZENDE, M. U.; HISSADOMI, M. I.; PAILO, A. F.; PASQUALIN, T.; CAMPOS, G. C.; FRUCCHI, R.
- Study on implant stability in cementless total knee arthroplasty(2012) TIRICO, Luis Eduardo Passarelli; PASQUALIN, Thiago; PECORA, Jose Otavio; GOBBI, Riccardo Gomes; PECORA, Jose Ricardo; DEMANGE, Marco KawamuraObjetives: Determine the stability of tibial and femoral components of 20 cementless knee arthroplasties with rotating platform. Methods: The 20 patients (20 knees) underwent an analysis of dynamic radiographs with an image amplifier and maneuvers of varus and valgus which were compared to static frontal and lateral radiographs of the knees and analyzed by two experienced surgeons in a double-blind way. Results: We could observe in this study that both methods showed very similar results for the stability of the tibial and femoral components (p<0.001) using the Kappa method for comparison. Conclusion: The tibial component was more unstable in relation to the femoral component in both static and dynamic studies. Level of Evidence IV, Case Series.
- PARQVE: PROJECT ARTHRITIS RECOVERING QUALITY OF LIFE THROUGH EDUCATION: TWO-YEAR RESULTS(2017) REZENDE, Marcia Uchoa de; FRUCCHI, Renato; PAILO, Alexandre Felicio; CAMPOS, Gustavo Constantino de; PASQUALIN, Thiago; HISSADOMI, Marcelo IssaoObjective: To evaluate the effects of a multi-professional educational program in patients with knee osteoarthritis (KOA). Methods: Prospective randomized controlled trial with 195 KOA patients. One group was submitted to two-day lectures and received educational material about KOA (Class group), and the control group received the educational material only. Patients were evaluated at baseline, twelve and 24 months. At evaluation, patients answered pain and functional questionnaires (WOMAC, Lequesne, VAS and SF-36); reported the intensity of exercise per week; measured the body fat percentage, weight and height to estimate body mass index (BMI); and performed Timed Up & Go (TUG) and Five-Times-Sit-to- Stand (FTSST) tests. Results: The groups presented similar results in all time points with respect to pain (VAS and WOMAC pain), WOMAC, BMI and body fat percentage (p>0.05). The Class group exhibited improved function according to the Lequesne questionnaire, whereas the control group worsened (p=0.02) during follow-up (p<0.02). TUG (p=0.01) and FTSST (p<0.001) improved in the Class group. A higher percentage of patients in the Class group performed regular physical activity (p=0.045). Conclusions: The educational program with classes improved the consistency of physical activity and the subjective and objective function of patients with KOA.
- ADDING TRIAMCINOLONE TO VISCOSUPPLEMENTATION: ONE YEAR OUTCOME OF RANDOMIZED TRIAL(2014) CAMPOS, G. C.; REZENDE, M. U.; FRUCHI, R.; PASQUALIN, T.; HISSADOMI, M. I.
- Randomized prospective study evaluating addition of corticoid to viscosupplementation: three months of follow-up(2013) CAMPOS, Gustavo Constantino de; REZENDE, Marcia Uchoa de; PAILO, Alexandre Felicio; FRUCCHI, Renato; PASQUALIM, Thiago; CAMARGO, Olavo Pires deOBJECTIVE: To assess if the initial results of viscosupplementation are improved by the addition of corticosteroid. DESIGN: We evaluated 104 patients receiving usual care for knee osteoarthritis at the Universidade de São Paulo Medical Center. Patients were randomized to receive either a single intra-articular injection of 6 mL of Hylan GF-20 (Group 1) or a single intra-articular injection of 6 mL of Hylan GF-20 plus 1 mL (20 mg) of Triamcinolone Hexacetonide (Group 2). VAS, WOMAC and Lequesne questionnaires were applied at weeks zero (prior the injection), and after one, four, and 12 weeks. RESULTS: The baseline measurements of the two groups with 52 patients each were not statistically different. At week one, WOMAC and VAS showed significantly better results for Group 2 compared to Group 1 (p < 0,05). At week four the scores did not show a statistically significant differences. The groups showed similar results at week 12. CONCLUSION: The addition of Triamcinolone Hexacetonide improves the short term symptom/functional scores of viscosupplementation.
- PARQVE - PROJECT ARTHRITIS RECOVERING QUALITY OF LIFE BY MEANS OF EDUCATION. ONE YEAR FOLLOW-UP. EFFECTS ON PAIN, FUNCTION, BMI AND QUALITY OF LIFE OF THE EDUCATIONAL PROGRAM, COPING SKILLS AND LEVEL OF EDUCATION(2014) REZENDE, M. U.; HISSADOMI, M. I.; FRUCCHI, R.; CAMPOS, G. C.; PAILO, A. F.; PASQUALIN, T.; SANTANA, O. F.; MOREIRA, M. M.; BRITO, N. L.; STRUTZ, C. G.; MATOS, N. B.; CAMARGO, O. P.
conferenceObject ANALYSIS OF ANTHROPOMETRIC MEASUREMENTS AND DIETARY INTAKE IN PATIENTS UNDERGOING A MULTI-PROFESSIONAL PROGRAM OSTEOARTHRITIS TREATMENT (PARQVE - PROJECT ARHTRITIS RECOVERING QUALITY OF LIFE BY MEANS OF EDUCATION)(2015) SR., N. L. Brito; REZENDE, M. U.; CAMPOS, G. C.; HISSADOMI, M. I.; PASQUALIM, T.; PAILO, A. F.; FRUCHI, R.; CAMARGO, O. P.- One-Year Results of an Educational Program on Osteoarthritis: A Prospective Randomized Controlled Trial in Brazil(2016) REZENDE, Marcia Uchoa de; HISSADOMI, Marcelo Issao; CAMPOS, Gustavo Constantino de; FRUCCHI, Renato; PAILO, Alexandre Felicio; PASQUALIN, Thiago; BRITO, Nadia Lucila Rocha; SANTANA, Olga Fugiko Magashima; MOREIRA, Merilu Marins; STRUTZ, Carolina Guimaraes; MATOS, Natalia Beraldo dos Santos; CAMARGO, Olavo Pires de; HERNANDEZ, Arnaldo JoseIntroduction: Knee osteoarthritis (KOA) is the most prevalent form of osteoarthritis. Low socioeconomic level, age, and obesity are directly correlated with the incidence of the disease. Education, exercise, and diet are the core recommendations of all KOA treatment guidelines. Objective: To evaluate the impact of a multiprofessional educational program on patients with KOA. Methods: Of a total of 198 participants, 150 patients with KOA attended 2 days of lectures (at 1- to 3-month intervals) and received educational material on osteoarthritis, and a control group (48 patients) received educational materials only. Body mass index (BMI), frequency, and intensity of physical activity, pain, function, and quality-of-life scores were assessed at baseline and at 4 and 12 months after the educational program. Bimonthly telephone calls were made to half of the participants. Correlations between BMI, level of education, coping skills, functional, and pain results was procured. Results: The groups were similar in terms of race, gender, affected side, and osteoarthritis severity. The results were not affected by the telephone calls or the patients' level of education. At baseline, 25 performed physical activity, whereas 123 performed at 1 year. Seventy-two (36.36%) patients decreased BMI (45 by 1 point and 27 by more than 2 points). There were some weak correlations such as BMI reduction with pain and functional improvements and with coping results. Significant improvements in function and quality of life were found at 4 months. Quality of life remained improved at 1 year. Conclusion: The effect of this educational program in function and quality of life of patients with KOA is very subtle. Interval between classes (1, 2, or 3 months) is not an important issue.
- SUBJECTIVE RESULTS OF JOINT LAVAGE AND VISCOSUPPLEMENTATION IN HEMOPHILIC ARTHROPATHY(2015) REZENDE, Marcia Uchoa de; ROSA, Thiago Bittencourt Carvalho; PASQUALIN, Thiago; FRUCCHI, Renato; OKAZAKI, Erica; VILLACA, Paula RibeiroObjective: To assess whether joint lavage, viscosupplementation and triamcinolone improve joint pain, function and quality of life in patients with severe hemophilic arthropathy. Methods: Fourteen patients with knee and/or ankle hemophilic arthritis with and without involvement of other joints underwent joint lavage and subsequent injection of hylan G-F20 and triamcinolone in all affected joints. The patients answered algo-functional questionnaires (Lequesne and WOMAC), visual analog scale for pain (VAS) and SF-36 preoperatively, and at one, three, six and twelve months postoperatively. Results: Sixteen knees, 15 ankles, 8 elbows and one shoulder were treated in 14 patients. Six patients had musculoskeletal bleeding [ankle (1), leg muscle (2) and knees (4)] at 3 months affecting the results. Pain did not improve significantly. Function improved (WOMAC p=0.02 and Lequesne p=0.01). The physical component of SF-36 improved at all time points except at 3 months, with best results at one-year follow-up (baseline = 33.4; 1 month = 39.6; 3 months = 37.6; 6 months 39.6 and 1 year = 44.6; p < 0.001). Conclusion: Joint lavage followed by injection of triamcinolone and hylan G-F20 improves function and quality of life progressively up to a year, even in severe hemophilic arthropathy.