PUBLIO CESAR CAVALCANTE VIANA

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Instituto de Radiologia, Hospital das Clínicas, Faculdade de Medicina
LIM/44 - Laboratório de Ressonância Magnética em Neurorradiologia, Hospital das Clínicas, Faculdade de Medicina

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Autor e Coautores FMUSP-HC Normalizados: RAFAEL FERREIRA COELHO ×

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  • article 33 Citação(ões) na Scopus
    Value of 3-Tesla multiparametric magnetic resonance imaging and targeted biopsy for improved risk stratification in patients considered for active surveillance
    (2017) PESSOA, Rodrigo R.; VIANA, Publio C.; MATTEDI, Romulo L.; GUGLIELMETTI, Giuliano B.; CORDEIRO, Mauricio D.; COELHO, Rafael F.; NAHAS, William C.; SROUGI, Miguel
    Objective To evaluate the role of multiparametric magnetic resonance imaging (mpMRI) of the prostate and transrectal ultrasonography guided biopsy (TRUS-Bx) with visual estimation in early risk stratification of patients with prostate cancer on active surveillance (AS). Patients and Methods Patients with low-risk, low-grade, localised prostate cancer were prospectively enrolled and submitted to a 3-T 16-channel cardiac surface coil mpMRI of the prostate and confirmatory biopsy (CBx), which included a standard biopsy (SBx) and visual estimation-guided TRUS-Bx. Cancersuspicious regions were defined using Prostate Imaging Reporting and Data System (PI-RADS) scores. Reclassification occurred if CBx confirmed the presence of a Gleason score >= 7, greater than three positive fragments, or >= 50% involvement of any core. The performance of mpMRI for the prediction of CBx results was assessed. Univariate and multivariate logistic regressions were performed to study relationships between age, prostate-specific antigen (PSA) level, PSA density (PSAD), number of positive cores in the initial biopsy, and mpMRI grade on CBx reclassification. Our report is consistent with the Standards of Reporting for MRItargeted Biopsy Studies (START) guidelines. Results In all, 105 patients were available for analysis in the study. From this cohort, 42 (40%) had PI-RADS 1, 2, or 3 lesions and 63 (60%) had only grade 4 or 5 lesions. Overall, 87 patients underwent visual estimation TRUS-Bx. Reclassification among patients with PI-RADS 1, 2, 3, 4, and 5 was 0%, 23.1%, 9.1%, 74.5%, and 100%, respectively. Overall, mpMRI sensitivity, specificity, positive predictive value, and negative predictive value for disease reclassification were 92.5%, 76%, 81%, and 90.5%, respectively. In the multivariate analysis, only PSAD and mpMRI remained significant for reclassification (P < 0.05). In the crosstabulation, SBx would have missed 15 significant cases detected by targeted biopsy, but SBx did detect five cases of significant cancer not detected by targeted biopsy alone. Conclusion Multiparametric magnetic resonance imaging is a significant tool for predicting cancer severity reclassification on CBx among AS candidates. The reclassification rate on CBx is particularly high in the group of patients who have PI-RADS grades 4 or 5 lesions. Despite the usefulness of visual-guided biopsy, it still remains highly recommended to retrieve standard fragments during CBx in order to avoid missing significant tumours.
  • article 0 Citação(ões) na Scopus
    Case 297: Mucinous Adenocarcinoma of the Prostate
    (2022) KANAS, Alexandre Fligelman; FENELON, Sandro Santos; SANTOS, Joao Manoel Miranda Magalhaes; COELHO, Rafael Ferreira; GUGLIELMETTI, Giuliano Betoni; NAHAS, William Carlos; VIANA, Publio Cesar Cavalcante
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    CAN MAGNETIC RESONANCE IMAGING REDUCE POSITIVE SURGICAL MARGINS IN RADICAL PROSTATECTOMY?
    (2016) PADOVANI, Guilherme; ANJOS, Gabriel; GUGLIELMETTI, Giuliano; FRANCA, Regis; VIANA, Publio; CORDEIRO, Mauricio; COELHO, Rafael; NAHAS, William
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    Randomized phase II trial of neoadjuvant androgen deprivation therapy plus abiraterone and apalutamide for patients with high-risk localized prostate cancer: Pathologic response and PSMA imaging correlates.
    (2022) BASTOS, Diogo Assed; COELHO, Rafael; CARDILI, Leonardo; GALIZA, Felipe; ILARIO, Eder Nisi; VIANA, Ublio; MURTA, Claudio Bovolenta; GUGLIELMETTI, Giuliano; CORDEIRO, Mauricio; PONTES JR., Jose; MUNIZ, David Queiroz Borges; SILVA, Jamile Almeida; MOTA, Jose Mauricio; FREITAS, Guilherme Fialho De; LEITE, Katia Ramos Moreira; BUCHPIGUEL, Carlos Alberto; NAHAS, William Carlos
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    Tumor contact length used as a biomarker to predict extracapsular extension, lymph node involvement, and biochemical recurrence.
    (2019) VIANA, Publio; RODRIGUES, Thiana; MOTA, Davi Alves Martins; GUGLIELMETTI, Giuliano; BASTOS, Diogo Assed; FAZOLI, Arnaldo; NAHAS, William Carlos; COELHO, Rafael; CORDEIRO, Mauricio; HORVAT, Natally
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    Can tumor contact length predict extracapsular extension, lymph node involvement, and biochemical recurrence?
    (2018) VIANA, Publio; RODRIGUES, Thiana; PACHANI, Danilo; HORVAT, Natally; CARVALHO, Arnaldo Fazoli; GUGLIELMETTI, Giuliano; COELHO, Rafael; BASTOS, Diogo Assed; NAHAS, William Carlos
  • conferenceObject
    THE ACCURACY AND VALIDATION OF MULTIPARAMETRIC MAGNETIC RESONANCE IMAGING (MPMRI) USING PI-RADS V2 IN DISEASE UPGRADING ON RE-BIOPSY AMONG PATIENTS WITH LOW-RISK PROSTATE CANCER ON ACTIVE SURVEILLANCE (AS) - A BRAZILIAN PERSPECTIVE.
    (2017) VIANA, Publio; HORVAT, Natally; PESSOA, Rodrigo; RODRIGUES, Thiana; GUGLIELMETTI, Giuliano; COELHO, Rafael; PARK, Rubens; VARGAS, Herbert Alberto; NAHAS, Willian
  • article 1 Citação(ões) na Scopus
    Current concepts in multiparametric magnetic resonance imaging for active surveillance of prostate cancer
    (2018) CAVALCANTE, Alexandre; VIANA, Publio Cesar C.; GUGLIELMETTI, Giuliano B.; PONTES, Jose; NONEMACHER, Henrique; CORDEIRO, Mauricio D.; BEZERRA, Regis Otaviano F.; COELHO, Rafael F.; NAHAS, William Carlos
  • article 0 Citação(ões) na Scopus
    Case 297
    (2021) KANAS, Alexandre Fligelman; FENELON, Sandro Santos; SANTOS, Joao Manoel Miranda Magalhaes; COELHO, Rafael Ferreira; GUGLIELMETTI, Giuliano Betoni; NAHAS, William Carlos; VIANA, Publio Cesar Cavalcante
    History A 70-year-old man was referred to our institution with chronic obstructive urinary symptoms and constipation for 2 years before admission. His medical history was unremarkable. Outside laboratory tests revealed an elevated serum prostate-specific antigen level (21.7 ng/mL [normal range, 0.00-4.00 ng/mL]), and urinalysis results were negative. He was admitted for evaluation of possible prostate cancer. The patient reported no specific symptoms of infection and denied fever, dysuria, hematuria, and abdominal pain. He had no family history of prostate cancer. On physical examination, he was afebrile, and the digital rectal examination was not painful. These findings were evidence of an enlarged prostate and a hard multilobulated mass, which was palpable bilaterally. The urologic team performed MRI of the prostate (Figs 1-4)
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    Multiparametric magnetic resonance imaging (mpMRl) and PSA density for the prediction of reclassification among patients under active surveillance.
    (2019) VIANA, Publio; HORVAT, Natally; PESSOA, Rodrigo Rodrigues; HORVAT, Joao; PARK, Rubens; GUGLIELMETTI, Giuliano; BASTOS, Diogo Assed; CORDEIRO, Mauricio; COELHO, Rafael; VARGAS, Hebert Alberto; NAHAS, William Carlos