CASSIO MACHADO DE CAMPOS BOTTINO
Projetos de Pesquisa
Unidades Organizacionais
LIM/21 - Laboratório de Neuroimagem em Psiquiatria, Hospital das Clínicas, Faculdade de Medicina - Líder
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- Frontal Lobe Degeneration in Adults with Down Syndrome and Alzheimer's Disease: A Review(2016) FONSECA, Luciana Mascarenhas; YOKOMIZO, Juliana Emy; BOTTINO, Cassio Machado; FUENTES, DanielBackground: There is a proven link between Down syndrome and the early development of the neuropathological features of Alzheimer's disease (AD). Changes in the personality and behavior of adults with Down syndrome might indicate the early stages of dementia or of frontotemporal lobar degeneration. The objective of this study was to investigate the executive functions and changes in behavior associated with frontal lobe degeneration in individuals with Down syndrome who develop AD. We conducted a systematic review selecting studies employing cognitive assessments. Summary: We identified few studies using objective measurements to determine whether cognitive aspects associated with the frontal lobe correlate with dementia in this population. We observed a tendency toward such correlations. (C) 2016 S. Karger AG, Basel
conferenceObject Effectiveness of general practitioners assessment of cognition (GPCOG) in a Brazilian population-Preliminary results(2013) BOTTINO, Cassio; YOKOMIZO, J.; GUELERI, R.; BRANDAO, M.; OLIVEIRA, G. De; SILVA, L.; YASSUDA, M.; SARAN, L.- The Geriatric Anxiety Inventory in primary care: applicability and psychometric characteristics of the original and short form(2016) SILVA, Lais dos Santos Vinholi e; OLIVEIRA, Glaucia Martins de; YOKOMIZO, Juliana Emy; SARAN, Laura Ferreira; BOTTINO, Cassio Machado de Campos; YASSUDA, Monica SanchesBackground: Generalized anxiety disorder (GAD) has negative implications for people's lives, but is often underdiagnosed in the elderly. There is a shortage of instruments to assess geriatric anxiety. Objectives: To analyze the applicability and psychometric properties of the Portuguese version of the Geriatric Anxiety Inventory (GAI) and its short form (GAI-SF) within primary care. Methods: Fifty-five seniors were classified as non-demented by a multidisciplinary panel. The protocol included the GAI, the Self-Reporting Questionnaire (SRQ-20), the Depression Scale D-10, Mini-Mental State Examination (MMSE), Bayer Scale for Activities of Daily Living (B-ADL) and the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE). A sub-sample also completed the Beck Anxiety Inventory (BAI). Results: The GAI and GAI-SF showed good internal consistency (0.89; 0.62, respectively) and test-retest stability (0.58, 0.97). The GAI and GAI-SF correlated significantly with the SRQ-20 (0.74, 0.55) and BAI (0.75, 0.58). Discussion: The psychometric characteristics of the Brazilian versions of the GAI and GAI-SF suggest these instruments are suitable for application in the Brazilian elderly population within the primary care setting.
- Cognitive screening test in primary care: cut points for low education(2018) YOKOMIZO, Juliana Emy; SEEHER, Katrin; OLIVEIRA, Glaucia Martins de; SILVA, Lais dos Santos Vinholi e; SARAN, Laura; BRODATY, Henry; APRAHAMIAN, Ivan; YASSUDA, Monica Sanches; BOTTINO, Cassio Machado de CamposOBJECTIVE: To establish the diagnostic accuracy of the Brazilian version of the General Practitioner Assessment of Cognition (GPCOG-Br) compared to the Mini-Mental State Examination (MMSE) in individuals with low educational level. METHODS: Ninety-three patients (>= 60 years old) from Brazilian primary care units provided sociodemographic, cognitive, and functional data. Receiver operating characteristics, areas under the curve (AUC) and logistic regressions were conducted. RESULTS: Sixty-eight patients with 0-4 years of education. Cases (n = 44) were older (p = 0.006) and performed worse than controls (n = 49) on all cognitive or functional measures (p < 0.001). The GPCOG-Br demonstrated similar diagnostic accuracy to the MMSE (AUC = 0.90 and 0.91, respectively) and similar positive and negative predictive values (PPV/NPV, respectively: 0.79/0.86 for GPCOG-Br and 0.79/0.81 for MMSE). Adjusted cut-points displayed high sensitivity (all 86%) and satisfactory specificity (65%-80%). Lower educational level predicted lower cognitive performance. CONCLUSIONS: The GPCOG-Br is clinically well-suited for use in primary care.
- Cognitive intervention in amnestic Mild Cognitive Impairment: A systematic review(2012) SIMON, Sharon Sanz; YOKOMIZO, Juliana Emy; BOTTINO, Cassio M. C.Mild Cognitive Impairment (MCI) represents a transitional state between normal aging and early dementia and is commonly associated with memory impairment (amnestic or A-MCI). Several studies have investigated therapeutic approaches to A-MCI, including cholinestherase inhibitors (I-ChEs), although this practice is still controversial. Thus, there is a current need to determine the effects of cognitive interventions either in combination with I-ChEs or alone. To assess the efficacy of such treatments, neuropsychological instruments and self-evaluated scoring of memory, mood, daily life activities and quality of life are employed. Recently, some studies have used functional magnetic resonance imaging (fMRI) in order to understand the neurobiological effects of these interventions. The aim of this systematic review is to investigate the effectiveness of cognitive interventions on the enhancement of learning abilities as well as their impacts on cognitive measurements of mood, everyday functioning and functional neuroimaging. This review also focused on the methodological aspects of such studies and attempted to introduce new perspectives on cognitive interventions in this population. The authors concluded that a-MCI patients are capable to learn new information and memory strategies. Although findings in standardized neuropsychological tests are limited, non-standardized cognitive measures and subjective measures show significant changes. Furthermore, fMRI reveals changes in the patterns of brain activation and increase of connectivity.
- The applicability of the cognitive abilities screening instrument-short (CASI-S) in primary care in Brazil(2016) OLIVEIRA, Glaucia Martins de; YOKOMIZO, Juliana Emy; SILVA, Lais dos Santos Vinholi e; SARAN, Laura Ferreira; BOTTINO, Cassio M. C.; YASSUDA, Monica SanchesBackground: The Cognitive Abilities Screening Instrument - Short (CASI-S) is a brief cognitive screening test. However, there is limited information regarding its applicability in primary care. Objectives: To ascertain whether the CASI-S differentiates between dementia patients and normal controls in primary care; to examine its correlation with other cognitive instruments, to analyze its internal consistency, test-retest stability, and diagnostic accuracy. Methods: In a case-control study, carried out at two Primary Care Units (PCUs) in the eastern region of the city of SAo Paulo, 47 older adults were diagnosed with dementia according to DSM-IV criteria (mean age = 76.81 7.03 years), and 55 were classified as normal controls (mean age = 72.78 7.37 years), by a multidisciplinary panel which had access to results from a comprehensive cognitive battery and the patients' health data. The present analyses included results from the Mini-Mental State Examination (MMSE). The CASI-S was not used to determine diagnostic status. Results: The CASI-S was easily applied in the primary care setting. There was a significant performance difference (p < 0.001) between dementia patients (15.57 +/- 7.40) and normal controls (26.67 +/- 3.52) on the CASI-S. CASI-S scores correlated with age ( = -0.410, p < 0.001), educational level ( = 0.373, p < 0.001), and MMSE score ( = 0.793, p < 0.001). The internal consistency of the CASI-S was high ( = 0.848) and the correlation between test and retest was 0.688, suggesting adequate temporal stability. In the ROC curve analyses, scores of 22/23 generated an area under the curve of 0.907, with sensitivity of 93% and specificity of 81%. Conclusions: The CASI-S can be useful for dementia screening in primary care in Brazil.
- Cognitive screening for dementia in primary care: a systematic review(2014) YOKOMIZO, Juliana Emy; SIMON, Sharon Sanz; BOTTINO, Cassio Machado de CamposBackground: Identifying dementia in primary care could minimize the impact of a late intervention; however, it shows high rates of misdiagnosis. One of the reasons seems to be the lack of knowledge of adequate cognitive screening instruments. This is a systematic review of the available instruments for the primary care context. Method: For this systematic review, articles were collected according to the following combined key terms: ""cognitive screening"" and ""dementia"" and ""primary care"" and ""review"". Studies should be reviews focusing on cognitive screening instruments best used in primary care setting. Results: Thirteen reviews were selected. In total, it was considered 34 cognitive screening instruments. Half of the instruments can be applied in an adequate time-limit for primary care context. Memory is the most commonly assessed cognitive function (91%). Almost half of the tests are mentioned to have influence of education or cultural factors (44%). Conclusion: Tests such as 6CIT, AMT, GPCOG, Mini-Cog, MIS, MoCA, and STMS seem to be good alternatives to the use of the Mini-Mental State Examination when considering factors such as application time, sensitivity, specificity, and number of studies. However, there is a wide range of tests with different characteristics, therefore it is recommended that the professional gets some expertise in a few number of instruments in order to be able to choose which to use, or use in combination, depending on the setting and the profile of the patient.