HERNANDEZ MOURA SILVA
Projetos de Pesquisa
Unidades Organizacionais
1 resultados
Resultados de Busca
Agora exibindo 1 - 1 de 1
- GATA3 and a dominant regulatory gene expression profile discriminate operational tolerance in human transplantation(2012) MORAES-VIEIRA, Pedro Manoel M.; TAKENAKA, Maisa C. S.; SILVA, Hernandez M.; MONTEIRO, Sandra Maria; AGENA, Fabiana; LEMOS, Francine; SAITOVITCH, David; KALIL, Jorge; COELHO, VeronicaSome organ-transplanted patients achieve a state of ""operational tolerance"" (01) in which graft function is maintained after the complete withdrawal of immunosuppressive drugs. We used a gene panel of regulatory/inflammatory molecules (FOXP3, GATA3, 100, TGFB1, TGFBR1/TBX21, TNF and IFNG) to investigate the gene expression profile in peripheral blood mononuclear cells of renal-transplanted individuals experiencing OT compared to transplanted individuals not displaying OT and healthy individuals (HI). OT subjects showed a predominant regulatory (REG) profile with higher gene expression of GATA3, FOXP3, TGFB1 and TGFB receptor 1 compared to the other groups. This predominant REG gene expression profile displayed stability over time. The significant GATA3 gene and protein expressions in OT individuals suggest that a Th2 deviation may be a relevant pathway to OT. Moreover, the capacity of the REG/INFLAMMA gene panel to discriminate OT by peripheral blood analysis indicates that this state has systemic repercussions.