MARILIA HARUMI HIGUCHI DOS SANTOS

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  • article 107 Citação(ões) na Scopus
    Cardiovascular Effects of Androgen Deprivation Therapy for the Treatment of Prostate Cancer ABCDE Steps to Reduce Cardiovascular Disease in Patients With Prostate Cancer
    (2016) BHATIA, Nirmanmoh; SANTOS, Marilia; JONES, Lee W.; BECKMAN, Joshua A.; PENSON, David F.; MORGANS, Alicia K.; MOSLEHI, Javid
  • article
    BRAZILIAN DIRECTOR OF CARDIO-ONCOLOGY OF THE BRAZILIAN CARDIOLOGY SOCIETY ACHIEVEMENT
    (2011) KALIL FILHO, Roberto; HAJJAR, Ludhmila Abrahao; BACAL, Fernando; HOFF, Paulo Marcelo Gehm; DIZ, Maria Del Pilar Estevez; GALAS, Filomena Regina Barbosa Gomes; FUKUSHIMA, Julia Tizue; ALMEIDA, Juliano Pinheiro de; NAKAMURA, Rosana Ely; TRIELLI, Thalia Rodrigues; BITTAR, Cristina Salvadori; SANTOS, Marilia Harumi dos; GALDEANO, Flavia Gomes; AULER JUNIOR, Jose Otavio da Costa; SILVESTRINI, Anderson Arantes; ALENCAR, Aristoteles; MOTA, Augusto Cesar de Andrade; GUSMAO, Cid Abreu Buarque de; ALMEIDA, Dirceu Rodrigues; SIMOES, Claudia Marques; BOCCHI, Edimar Alcides; LIMA, Enaldo Melo de; FERNANDES, Fabio; SILVEIRA, Fabio Serra; VILAS-BOAS, Fabio; SILVA NETO, Luis Beck da; ROHDE, Luis Eduardo Paim; MONTERA, Marcelo Westerlund; BARBOSA, Marcia; MANO, Max Senna; RIECHELMANN, Rachel Simoes; ARAI, Roberto Jun; MARTINS, Silvia M.; FERREIRA, Silvia Moreira Ayub; SANTOS, Veronica
  • conferenceObject
    CARDIOVASCULAR MORTALITY AND MYOCARDIAL INFARCTION AFTER RADIATION THERAPY FOR LEFT VERSUS RIGHT SIDED BREAST CANCER: A META-ANALYSIS
    (2016) BITTENCOURT, Marcio Sommer; VECSEY-NAGY, Milan; SANTOS, Marilia; SILVA, Carolina; FONSECA, Silvia M.; BITTAR, Cristina S.; HOFF, Paulo G.; KALIL-FILHO, Roberto; HAJJAR, Ludhmila A.
  • conferenceObject
    SERUM ACTIVE COLLAGENASE FROM PATHOGENIC ARCHAEAL COLLAGENASE MAY CAUSE HEART FAILURE IN CHAGASIC PATIENTS
    (2019) HIGUCHI, Maria De Lourdes; KAWAKAMI, Joyce; IKEGAMI, Renata; REIS, Marcia; MORENO, Camila R.; PEREIRA, Jaqueline; IANNI, Barbara; BUCK, Paula; SANTOS, Marilia; BOCCHI, Edimar
  • conferenceObject
    Evaluation of Late Cardiotoxicity in Lymphoma Survivors
    (2017) LIGUORI, Thiago; GALAS, Filomena R.; SANTOS, Marilia H.; ALMEIDA, Juliano P. de; FUKUSHIMA, Julia T.; MENEGUETTI, Claudio; PEREIRA, Juliana; BELESSO, Marcelo; ROCHA, Wanderson; HAJJAR, Ludhmila A.
  • bookPart
    O acometimento cardiovascular no paciente com câncer
    (2013) HAJJAR, Ludhmila Abrahão; BITTAR, Cristina Salvadori; SANTOS, Marília Harumi Higuchi dos; KALIL FILHO, Roberto
  • article 19 Citação(ões) na Scopus
    Previous exercise training increases levels of PPAR-alpha in long-term post-myocardial infarction in rats, which is correlated with better inflammatory response
    (2016) SANTOS, Marilia Harumi Higuchi; HIGUCHI, Maria de Lourdes; TUCCI, Paulo J. F.; GARAVELO, Sherrira M.; REIS, Marcia M.; ANTONIO, Ednei L.; SERRA, Andrey J.; MARANHAO, Raul Cavalcante
    OBJECTIVE: Exercise is a protective factor for cardiovascular morbidity and mortality, with unclear mechanisms. Changing the myocardial metabolism causes harmful consequences for heart function and exercise contributes to metabolic adjustment modulation. Peroxisome proliferator-activated receptors (PPARs) are also myocardium metabolism regulators capable of decreasing the inflammatory response. We hypothesized that PPAR-alpha is involved in the beneficial effects of previous exercise on myocardial infarction (MI) and cardiac function, changing the expression of metabolic and inflammatory response regulators and reducing myocardial apoptosis, which partially explains the better outcome. METHODS AND RESULTS: Exercised rats engaged in swimming sessions for 60 min/day, 5 days/week, for 8 weeks. Both the exercised rats and sedentary rats were randomized to MI surgery and followed for 1 week (EI1 or SI1) or 4 weeks (EI4 or SI4) of healing or to sham groups. Echocardiography was employed to detect left ventricular function and the infarct size. Additionally, the TUNEL technique was used to assess apoptosis and immunohistochemistry was used to quantitatively analyze the PPAR-alpha, TNF-alpha and NF-kappa B antigens in the infarcted and non-infarcted myocardium. MI-related mortality was higher in SI4 than in EI4 (25% vs 12%), without a difference in MI size. SI4 exhibited a lower shortening fraction than EI4 did (24% vs 35%) and a higher apoptosis/area rate (3.97 +/- 0.61 vs 1.90 +/- 1.82) in infarcted areas (both p=0.001). Immunohistochemistry also revealed higher TNF-alpha levels in SI1 than in EI1 (9.59 vs 4.09, p<0.001) in infarcted areas. In non-infarcted areas, EI4 showed higher levels of TNF-alpha and positive correlations between PPAR-alpha and NF-kappa B (r=0.75, p=0.02), in contrast to SI4 (r=0.05, p=0.87). CONCLUSION: Previously exercised animals had better long-term ventricular function post-MI, in addition to lower levels of local inflammatory markers and less myocardial apoptosis, which seemed to be related to the presence of PPAR-alpha.
  • article 12 Citação(ões) na Scopus
    Cardiac Implications after Myocardial Infarction in Rats previously Undergoing Physical Exercise
    (2013) VEIGA, Eduardo Carvalho de Arruda; PORTES, Leslie Andrews; BOCALINI, Danilo Sales; ANTONIO, Ednei Luiz; SANTOS, Alexandra Alberta dos; SANTOS, Marilia Higuchi; SILVA, Flavio Andre; TUCCI, Paulo Jose Ferreira
    Background: Few studies have analyzed the cardiac effects of exercise prior to coronary occlusion. Objective: To evaluate the effects of myocardial infarction in rats undergoing physical exercise. Methods: Female rats underwent swimming exercise or were kept sedentary for eight weeks and were randomized to coronary occlusion or sham surgery, in one of the following four groups: Sedentary (S), exercise (E), Sedentary myocardial infarction (SMI) and Exercise myocardial infarction (EMI). After six weeks, their biometrics, Doppler echocardiography, hemodynamics and myocardial mechanics were analyzed. Results: No cardioprotection was observed in EMI animals and there was no difference in infarct size (%LV) between EMI (38.50 +/- 4.60%) and SMI (36.58 +/- 4.11%). Water content of the lung (%) of SMI (80 +/- 0.59) and EMI (80 +/- 0.57) was higher than that of S (78 +/- 0.15) and E (78 +/- 0.57) groups. Left ventricular systolic pressure (mmHg) (S: 130 +/- 5, E: 118 +/- 8; SMI: 91 +/- 3; EMI: 98 +/- 3) and the first positive time derivative (mmHg) positive pressure (S: 8216 +/- 385; E: 8437 +/- 572; SMI: 4674 +/- 455; EMI: 5080 +/- 412) of S and E were higher than those of SMI and EMI. The transverse fractional shortening (%) of SMI (27 +/- 2) and EMI (25 +/- 2) were similar and lower than that of E (65 +/- 2) and S (69 +/- 2). The E/A ratio was higher in SMI (5.14 +/- 0.61) and EMI (4.73 +/- 0.57) compared to S (2.96 +/- 0.24) and E (2.83 +/- 0 21). In studies of isolated papillary muscle, depression of the contractile capacity observed was similar to that of SMI and EMI, and there was no change in myocardial stiffness. Conclusion: Previous training by swimming did not attenuate cardiac implications due to myocardial infarction. (Arq Bras Cardiol. 2013;100(1):37-43)
  • bookPart
    Interação Cardio-Oncológica
    (2016) SANTOS, Marilia Harumi Higuchi dos; KALIL FILHO, Roberto
  • article 3 Citação(ões) na Scopus