MAIKON BARBOSA DA SILVA

Índice h a partir de 2011
5
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Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação, Hospital das Clínicas, Faculdade de Medicina

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  • article 39 Citação(ões) na Scopus
    Impact of aging on cardiac function in a female rat model of menopause: role of autonomic control, inflammation, and oxidative stress
    (2016) MACHI, Jacqueline Freire; DIAS, Danielle da Silva; FREITAS, Sarah Cristina; MORAES, Oscar Albuquerque de; SILVA, Maikon Barbosa da; CRUZ, Paula Lazara; MOSTARDA, Cristiano; SALEMI, Vera M. C.; MORRIS, Mariana; ANGELIS, Katia De; IRIGOYEN, Maria-Claudia
    Objective: The aim of this study was to evaluate the effects of aging on metabolic, cardiovascular, autonomic, inflammatory, and oxidative stress parameters after ovarian hormone deprivation (OVX). Methods: Female Wistar rats (3 or 22 months old) were divided into: young controls, young ovariectomized, old controls, and old ovariectomized (bilateral ovaries removal). After a 9-week follow-up, physical capacity, metabolic parameters, and morphometric and cardiac functions were assessed. Subsequently, arterial pressure was recorded and cardiac autonomic control was evaluated. Oxidative stress was measured on the cardiac tissue, while inflammatory profile was assessed in the plasma. Results: Aging or OVX caused an increase in body and fat weight and triglyceride concentration and a decrease in both insulin sensitivity and aerobic exercise capacity. Left ventricular diastolic dysfunction and increased cardiac overload (myocardial performance index) were reported in old groups when compared with young groups. Aging and OVX led to an increased sympathetic tonus, and vagal tonus was lower only for the old groups. Tumor necrosis factor-a and interleukin-6 were increased in old groups when compared with young groups. Glutathione redox balance (GSH/GSSG) was reduced in young ovariectomized, old controls, and old ovariectomized groups when compared with young controls, indicating an increased oxidative stress. A negative correlation was found between GSH/GSSG and tumor necrosis factor-a (r=-0.6, P<0.003). Correlations were found between interleukin-6 with adipose tissue (r=0.5, P<0.009) and vagal tonus (r=-0.7, P<0.0002); and among myocardial performance index with interleukin-6 (r=0.65, P<0.0002), sympathetic tonus (r=0.55, P<0.006), and physical capacity (r=-0.55, P<0.003). The findings in this trial showed that ovariectomy aggravated the impairment of cardiac and functional effects of aging in female rats, probably associated with exacerbated autonomic dysfunction, inflammation, and oxidative stress.
  • article 14 Citação(ões) na Scopus
    Exercise Training Prevents Cardiovascular Derangements Induced by Fructose Overload in Developing Rats
    (2016) FARAH, Daniela; NUNES, Jonas; SARTORI, Michelle; DIAS, Danielle da Silva; SIRVENTE, Raquel; SILVA, Maikon B.; FIORINO, Patricia; MORRIS, Mariana; LLESUY, Susana; FARAH, Vera; IRIGOYEN, Maria-Claudia; ANGELIS, Katia De
    The risks of chronic diseases associated with the increasing consumption of fructose-laden foods are amplified by the lack of regular physical activity and have become a serious public health issue worldwide. Moreover, childhood eating habits are strongly related to metabolic syndrome in adults. Thus, we aimed to investigate the preventive role of exercise training undertaken concurrently with a high fructose diet on cardiac function, hemodynamics, cardiovascular autonomic modulation and oxidative stress in male rats after weaning. Male Wistar rats were divided into 4 groups (n = 8/group):Sedentary control (SC), Trained control (TC), Sedentary Fructose (SF) and Trained Fructose (TF). Training was performed on a treadmill (8 weeks, 40-60% of maximum exercise test). Evaluations of cardiac function, hemodynamics, cardiovascular autonomic modulation and oxidative stress in plasma and in left ventricle (LV) were performed. Chronic fructose overload induced glucose intolerance and an increase in white adipose tissue (WAT) weight, in myocardial performance index (MPI) (SF:0.42 +/- 0.04 vs. SC:0.24 +/- 0.05) and in arterial pressure (SF:122 +/- 3 vs. SC:113 +/- 1 mmHg) associated with increased cardiac and vascular sympathetic modulation. Fructose also induced unfavorable changes in oxidative stress profile (plasmatic protein oxidationSF: 3.30 +/- 0.09 vs. SC:1.45 +/- 0.08 nmol/mg prot; and LV total antioxidant capacity (TRAP)SF: 2.5 +/- 0.5 vs. SC:12.7 +/- 1.7 uM trolox). The TF group showed reduced WAT, glucose intolerance, MPI (0.35 +/- 0.04), arterial pressure (118 +/- 2mmHg), sympathetic modulation, plasmatic protein oxidation and increased TRAP when compared to SF group. Therefore, our findings indicate that cardiometabolic dysfunctions induced by fructose overload early in life may be prevented by moderate aerobic exercise training.