DIOGO CORDEIRO DE QUEIROZ SOARES
Projetos de Pesquisa
Unidades Organizacionais
LIM/03 - Laboratório de Medicina Laboratorial, Hospital das Clínicas, Faculdade de Medicina
8 resultados
Resultados de Busca
Agora exibindo 1 - 8 de 8
conferenceObject Analysis of soluble mediators of promotion and suppression of the immune response in patients with the 22q11.2 deletion syndrome(2021) SOARES, Diogo; KIM, Chong; TORRES, Leuridan; DANTAS, Anelisa; NUNES, Natalia; MELARAGNO, Maria Isabel; CARNEIRO-SAMPAIO, Magda- CD4(+)CD25(high)Foxp3(+) Treg deficiency in a Brazilian patient with Gaucher disease and lupus nephritis(2016) MATTA, Marina Cadena; SOARES, Diogo Cordeiro; KERSTENETZKY, Marcelo Soares; FREITAS, Augustus Cesar Pinto; KIM, Chong Ae; TORRES, Leuridan CavalcanteGaucher Disease (GD) is a rare autosomal recessive disorder caused by the deficient activity of beta-glucocerebrosidase. GD is one of the lysosomal storage diseases with the most remarkable alterations in the immune system, and that may manifest clinically as autoimmune disorders and malignancy. We reported the immunological evaluation of a patient with GD and lupus nephritis. Decreased absolute values of T, and NK, and an inversion of CD4(+)/CD8(+) ratio, low levels of IgM and normal B cells were found when compared to reference values in a Brazilian population. Absence ofCD4(+)CD25(high)Foxp3(+) Treg and high levels of total NKT, iNKT cells and CD8(+) iNKT subsets were also observed when compared to the healthy control and GD patient without lupus nephritis. Treg subset and CD8(+) iNKT abnormalities might be involved in severe lupus nephritis in a GD patient. We conclude by emphasizing the importance of the immunological evaluation on early diagnosis of autoimmunity contributing to reduce mortality and morbidity of these patients.
conferenceObject 16q24 DUPLICATION AND IVEMARK SYNDROME: A NOVEL GENOMIC CAUSE?(2017) SOARES, Diogo C.; PIAZZON, Flavia B.; ZANARDO, Evelin; PASTORINO, Antonio Carlos; KULIKOWSKI, Leslie D.; BERTOLA, Debora R.; CARNEIRO-SAMPAIO, Magda; KIM, Chong Ae- Lymphoproliferative disorder with polyautoimmunity and hypogammaglobulinemia: An unusual presentation of 22q11.2 deletion syndrome(2020) SOARES, Diogo C.; DANTAS, Anelisa G.; MATTA, Marina C.; PASTORINO, Antonio C.; MELARAGNO, Maria Isabel; KULIKOWSKI, Leslie; MONTENEGRO, Marilia; KIM, Chong A.; CARNEIRO-SAMPAIO, Magda; TORRES, Leuridan C.22q11.2 deletion syndrome (22q11.2DS) has a heterogeneous presentation that includes multiple congenital anomalies and immunodeficiency, one of the most striking features. Usually, it is characterized by T cell lymphopenia, B cell dysfunction and autoimmunity. Here, we describe an unusual case of 22q11.2DS in a patient with lymphoproliferative disorder, polyautoimmunity and hypogammaglobulinemia.
conferenceObject HIGH LEVELS OF NKT CELLS IN CHRONIC GRANULOMATOUS DISEASE ASSOCIATED WITH HASHIMOTOXS THYROIDITIS: A CASE REPORT(2016) SOARES, Diogo C.; ALBUQUERQUE FILHO, Francisco S.; FALCAO, Ana Carla Augusto Moura; CORREIA, Jailson B.; TORRES, Leuridan C.; CARNEIRO-SAMPAIO, Magda- NK and B cell deficiency in a MPS type II family with novel mutation in the IDS gene(2014) TORRES, Leuridan Cavalcante; SOARES, Diogo Cordeiro de Queiroz; KULIKOWSKI, Leslie Domenici; FRANCO, Jose Francisco; KIM, Chong AeThe mucopolysaccharidoses (MPSs) are a group of rare, inherited lysosomal storage disorders that are clinically characterized by abnormalities in multiple organ systems and reduced life expectancy. Whereas the lysosome is essential to the functioning of the immune system, some authors suggest that the MPS patients have abnormalities in the immune system similar to the patients with primary immunodeficiency. In this study, we evaluated 8 male MPS type II patients of the same family with novel mutation in the IDS gene. We found in this MPS family a quantitative deficiency of NK and B cells with normal values of IgG, IgM and IgA serum antibodies and normal response to polysaccharide antigens. Interestingly, abnormalities found in these patients were not observed in other MPS patients, suggesting that the type of mutation found in the IDS gene can be implicated in the immunodeficiency.
conferenceObject Lymphoproliferative Disorder with Hypogammaglobulinemia: an Unusual Presentation of 22q11.2 Deletion Syndrome(2017) SOARES, Diogo C.; NUNEZ, Evelyn Cristina; SANTOS, Cristiane J.; PASTORINO, Antonio C.; DANTAS, Anelisa G.; TORRES, Leuridan C.; ZANARDO, Evelin A.; KULIKOWSKI, Leslie D.; MELARAGNO, Maria Isabel; CARNEIRO-SAMPAIO, Magda M. S.; KIM, Chong AeconferenceObject HYPOGAMMAGLOBULINEMIA AND B CELL LYMPHOPENIA AS PHENOTYPE ASSOCIATED WITH CD25 DEFICIENCY(2016) SOARES, Diogo C.; AQUILANTE, Bruna; PASTORINO, Antonio Carlos; OLIVEIRA, Joao Bosco; KIM, Chong Ae; CARNEIRO-SAMPAIO, Magda