RENAN DIAS FRASSEI

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Instituto de Ortopedia e Traumatologia, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/04 - Laboratório de Microcirurgia, Hospital das Clínicas, Faculdade de Medicina

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  • article 0 Citação(ões) na Scopus
    Clinical data or scoring system for predicting mortality in elderly patients with hip fracture: A prospective study
    (2023) SOUZA, Ricardo Machado Castanheira de; FRASSEI, Renan Dias; SILVA, Luiza de Campos Moreira da; RAHAL, Miguel Antonio; SILVA, Jorge dos Santos; KOJIMA, Kodi Edson
    Introduction: Hip fracture in elderly individuals is frequent and is related to a high rate of mortality. Finding the best predictor of death will help to develop better patient care. Aim - To analyze the reliability of the clinical data and assessment scores to predict mortality in acute hip fracture in elderly patients. Patient and Methods: Prospective data were collected from all patients > 65 years with acute hip fracture from May to October 2020. The clinical data collected were age, sex, comorbidities, medication, type of fracture and presence of delirium. The assessment scores were ASA, Lee, ACP and Charlson. Results: The statistically significant results were age > 80 years (OR 1.121 IC95% [1.028-1.221] p = 0.0101) and number of medications (OR5.991 95% CI [2.422-14.823] p <0.001). Three scores showed a correlation with mortality: ASA score (p = 0.017), Lee score (p = 0.024) and ACP score (p = 0.013). The Charlson Comorbidity Index did not correlate with mortality (p = 0.172). Conclusion: To stratify the risk of death, both clinical data and scores should be used. The best clinical indicators are age and number of medications, and the scores are ASA, Lee and ACP.
  • article 0 Citação(ões) na Scopus
    Hyaluronic acid in tobacco-exposed rats. Inflammatory reaction, and duration of effects
    (2019) CAMARGO, Cristina Pires; FRASSEI, Renan Dias; SILVA, Daniel Imbassahy de Sa Bittencourt Camara e; PFANN, Robert Zawadzki; SILVA, Luiza de Campos Moreira da; MORAIS-BESTEIRO, Julio; GEMPERLI, Rolf
    Purpose: To evaluate the hyaluronic acid (HA) inflammatory reaction, fibroblasts, fibrosis and duration of effect in the dorsal region of tobacco-exposed rats. Methods: Ten Wistar rats were divided into two groups: tobacco-exposed-group (TEG;n=5) and air-control-group (CG;n=5). The TEG animals were tobacco-exposed twice a day, 30-minutes/session, during 60 days. After this period, all animals received 0.1 mL HA subcutaneous injection in the dorsal area. The volume of HA was measured immediately after HA injection and weekly using a hand-caliper in nine weeks. After this period, all the animals were euthanized, and a specimen of was collected to evaluate inflammatory cells, fibroblasts, and fibrosis by HE. Results: This study showed a higher inflammatory reaction in TEG than CG: inflammatory cell-count (CG: 1.07 +/- 0.9; TEG: 8.61 +/- 0.36, p<0.001); fibroblast count (CG: 2.92 +/- 0.17; TEG: 19.14 +/- 0.62, p<0.001), and fibrosis quantification (CG: 2.0; TEG: 3.75, p<0.001). The analysis of the HA volume in nine weeks in the dorsal region did not show a difference between groups (p=0.39). Conclusions: This study suggested that the HA injection in the TEG caused an increase in inflammatory cell count, fibroblast, and fibrosis quantification when compared to the CG. There was no difference in the duration of effect of HA between the groups.