LUIZ UBIRAJARA SENNES

(Fonte: Lattes)
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Lattes
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Departamento de Otorrinolaringologia e Oftalmologia, Faculdade de Medicina - Docente
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/63, Hospital das Clínicas, Faculdade de Medicina
LIM/32 - Laboratório de Otorrinolaringologia, Hospital das Clínicas, Faculdade de Medicina - Líder

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  • article 37 Citação(ões) na Scopus
    Sleep-disordered breathing in C57BL/6J mice with diet-induced obesity
    (2018) CURADO, Thomaz Fleury; PHO, Huy; BERGER, Slava; CABALLERO-ERASO, Candela; SHIN, Mi-Kyung; SENNES, Luiz Ubirajara; Luu Pham; SCHWARTZ, Alan R.; POLOTSKY, Vsevolod Y.
    Obesity leads to sleep-disordered breathing (SDB) manifested by recurrent upper airway obstructions termed obstructive sleep apnea (OSA) and carbon dioxide retention due to hypoventilation. The objective of this work was to characterize breathing during sleep in C57BL6/J mice with diet-induced obesity (DIO). Arterial blood gas was measured in nine obese and nine lean mice during wakefulness. Nine male mice with DIO and six lean male C57BL/6J mice were head mounted with electroencephalogram (EEG) and electromyogram (EMG) electrodes. Sleep recordings were performed in the whole body plethysmography chamber; upper airway obstruction was characterized by the presence of inspiratory flow limitation in which airflow plateaus with increases in inspiratory effort. Obese mice showed significantly lower pH and higher partial pressure of arterial CO2 (PaCO2) in arterial blood gas compared to lean mice, 7.35 +/- 0.04 versus 7.46 +/- 0.06 (p < 0.001) and 38 +/- 8 mm Hg versus 30 +/- 5 mm Hg (p < 0.001). Obese mice had similar levels of minute ventilation to lean mice during sleep and wakefulness, despite higher body weight and temperature, indicating an increase in the metabolic rate and hypoventilation. Obese mice also showed baseline hypoxemia with decreased mean oxyhemoglobin saturation across sleep/wake states. Obese mice had a higher prevalence of flow-limited breathing compared to lean mice during sleep. However, the oxygen desaturation index in lean and obese mice did not differ. We conclude that DIO in mice leads to hypoventilation. Obesity also increases the frequency of inspiratory limited breaths, but it does not translate into progression of OSA.
  • article 0 Citação(ões) na Scopus
    Anatomical terminology of the internal nose and paranasal sinuses: cross-cultural adaptation to Portuguese
    (2018) BEZERRA, Thiago Freire Pinto; STAMM, Aldo; ANSELMO-LIMA, Wilma Teresinha; FORNAZIERI, Marco Aurelio; MELO, Nelson D'Avila; BALSALOBRE, Leonardo; JOTZ, Geraldo Pereira; LEAO, Henrique Zaquia; NUNES, Andre Alencar Araripe; FELIPPU, Alexandre; CEDIN, Antonio Carlos; PINHEIRO-NETO, Carlos D.; OLIVEIRA, Diego Lima; SAKANO, Eulalia; KOSUGI, Eduardo Macoto; ARAUJO, Elizabeth; VALERA, Fabiana Cardoso Pereira; PINNA, Fabio de Rezende; ROMANO, Fabrizio Ricci; PADUA, Francine Grecco de Melo; RAMOS, Henrique Faria; TELLES JR., Joao; SA, Leonardo Conrado Barbosa de; D'ASSUNCAO FILHO, Leopoldo Marques; SENNES, Luiz Ubirajara; GREGORIO, Luis Carlos; SAMPAIO, Marcelo H.; SANTOS, Marco Cesar Jorge dos; FRANCA, Marco; MOCELLIN, Marcos; LESSA, Marcus Miranda; AVELINO, Melissa Ameloti G.; TEPEDINO, Miguel; ANDRADE, Nilvano Alves de; PILTCHER, Otavio B.; ROITHMANN, Renato; PILAN, Renata Mendonca; MEIRELES, Roberto Campos; GUIMARAES, Roberto Eustaquio; SANTOS, Rodrigo de Paula; PEZATO, Rogerio; PIGNATARI, Shirley; ABDO, Tatiana Telles; NAKAJIMA, Victor; ALMEIDA, Washington; VOEGELS, Richard L.
    Introduction: Functional endonasal endoscopic surgery is a frequent surgical procedure among otorhinolaryngologists. In 2014, the European Society of Rhinology published the ""European Position Paper on the Anatomical Terminology of the Internal Nose and Paranasal Sinuses"", aiming to unify the terms in the English language. We do not yet have a unified terminology in the Portuguese language. Objective: Transcultural adaptation of the anatomical terms of the nose and paranasal cavities of the ""European Anatomical Terminology of the Internal Nose and Paranasal Sinuses"" to Portuguese. Methods: A group of rhinologists from diverse parts of Brazil, all experienced in endoscopic endonasal surgery, was invited to participate in the creation of this position paper on the anatomical terms of the nose and paranasal sinuses in the Portuguese language according to the methodology adapted from that previously described by Rudmik and Smith. Results: The results of this document were generated based on the agreement of the majority of the participants according to the most popular suggestions among the rhinologists. A cross-cultural adaptation of the sinonasal anatomical terminology was consolidated. We suggest the terms ""inferior turbinate"", ""nasal septum"", ""(bone/cartilaginous) part of the nasal septum"", ""(middle/inferior) nasal meatus"", ""frontal sinus drainage pathway"", ""frontal recess"" and ""uncinate process"" be standardized. Conclusion: We have consolidated a Portuguese version of the European Anatomical Terminology of the Internal Nose and Paranasal Sinuses, which will help in the publication of technical announcements, scientific publications and the teaching of the internal anatomical terms of the nose and paranasal sinuses in Brazil. (C) 2018 Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial.