LUIZ UBIRAJARA SENNES

(Fonte: Lattes)
Índice h a partir de 2011
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Lattes
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Departamento de Otorrinolaringologia e Oftalmologia, Faculdade de Medicina - Docente
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/63, Hospital das Clínicas, Faculdade de Medicina
LIM/32 - Laboratório de Otorrinolaringologia, Hospital das Clínicas, Faculdade de Medicina - Líder

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  • article 3 Citação(ões) na Scopus
    Endoscopic anatomy of the approaches to the sellar area and planum sphenoidale
    (2011) RAMOS, Henrique Faria; MONTEIRO, Tatiana Alves; PINHEIRO NETO, Carlos Diogenes; MARIANI, Pedro Paulo; FORTES, Felipe Sartor Guimaraes; SENNES, Luiz Ubirajara
    The productive work between otolaryngologists and neurosurgeons has resulted in the emergence of endoscopic endonasal skull base surgery. The goal of the present study is to describe the endoscopic anatomy of the endonasal approach to the sellar region and planum sphenoidale, highlighting the key points of the surgical approach and the neurovascular landmarks. Method: Descriptive study of the endoscopic endonasal dissection of 9 fresh cadavers with exposure of the anatomic structures. Results: The endoscopic endonasal ethmoidectomy and sphenoidotomy allows an expanded access to the sellar area and planum sphenoidale. The surface anatomy of the sphenoid sinus is easily identifiable and provides safe landmarks, guiding the intracranial dissection. Conclusion: The endoscopic endonasal approach to the skull base by the ENT and neurosurgeon is feasible, but it requires adequate anatomical knowledge and endoscopic skills for its realization, which can be obtained by practicing in cadavers.
  • article 12 Citação(ões) na Scopus
    Endoscopic ligation of the anterior ethmoidal artery: a cadaver dissection study
    (2011) ARAUJO FILHO, Bernardo Cunha; PINHEIRO-NETO, Carlos Diogenes; RAMOS, Henrique Faria; VOEGELS, Richard Louis; SENNES, Luiz Ubirajara
    Anterior ethmoidal artery (AEA) ligation may be necessary in cases of severe epistaxis not controllable with traditional therapy. Endoscopic endonasal ligation of the AEA is not used frequently; there are few studies in the literature for standardization of the endoscopic technique for this vessel. Aim: To demonstrate the feasibility of periorbital AEA ligation in a transethmoidal endoscopic approach. Methods: A prospective study where 50 nasal cavities were dissected. After anterior ethmoidectomy and partial removal of lamina papyracea, the periorbital area was carefully dissected along a subperiosteal plane to identify the AEA. The vessel was exposed within the orbit and dissected. Results: Data on technical difficulties, complications, the learning curve and anatomical variations were gathered. Conclusion: An endonasal endoscopic approach to the AEA within the orbit was shown to be feasible. Identifying the artery is not difficult, and this technique avoids external incisions. This approach appears to be an excellent alternative for approaching the AEA. Further clinical studies are needed to demonstarte the benefits of this technique.
  • article 6 Citação(ões) na Scopus
    Effect of Fibrin Glue on Collagen Deposition After Autologous Fascia Grafting in Rabbit Vocal Folds
    (2011) SCAPINI, Fabricio; SILVA, Luiz Fernando Ferraz da; TSUJI, Domingos Hiroshi; DOLHNIKOFF, Marisa; SENNES, Luiz Ubirajara
    Objectives: Fibrin glue (FG) is a reaction product of fibrinogen and thrombin that forms a fibrin clot responsible for tissue adhesion. However, FG and its components may interfere with wound healing by interacting with cytokines such as transforming growth factor-beta (TGF-beta). The objective of this study was to investigate the effect of FG on collagen deposition after fascia grafting in the vocal folds of rabbits. Methods: Eighteen rabbits underwent autologous fascia grafting in both vocal folds, and the left side was fixed with FG. Each animal was painlessly sacrificed after 7,30, or 90 clays. The larynx was removed, and the vocal folds were prepared for histomorphometric analysis by picrosirius red staining to evaluate collagen deposition around the graft. Results: There was a significant increase in collagen density around the grafts at 90 days in the vocal folds that were fixed with FG (p = 0.0102) compared with the control vocal folds. Conclusions: Application of FG altered collagen deposition around the fascia grafts, leading to significantly increased collagen density after 90 days. Differences found in the composition of the extracellular matrix in later stages of the healing process are a result of changes that occur in the beginning of this process. Therapeutic interventions, such as the use of FG and/or its components, performed in the early stages of wound healing may interfere with the complex interactions of fibroblasts, inflammatory cells, and cytokines (especially TGF-beta), thereby modulating the healing process.
  • article 12 Citação(ões) na Scopus
    Collagen Type I, Collagen Type III, and Versican in Vocal Fold Lamina Propria
    (2011) BUEHLER, Rogerio B.; SENNES, Luiz U.; TSUJI, Domingos H.; MAUAD, Thais; SILVA, Luiz Ferraz da; SALDIVA, Paulo N.
    Objective: To analyze the distributions of collagen type I, collagen type III, and versican in the lamina propria of the human vocal fold. Design: Cross-sectional analysis of cadaveric vocal folds of adult human larynges. Setting: Academic tertiary referral center. Subjects: Larynges harvested at autopsy from 10 adult men and 10 adult women. Main Outcome Measures: Immunohistochemical reactions were performed using antihuman monoclonal antibodies to analyze the expression of collagen type I, collagen type III, and versican. Results: Collagen type I density was lower in the intermediate layer compared with the superficial and deep layers of vocal folds. Collagen type III density was lower in the intermediate layer compared with the deep layer. Versican density was lower in the superficial layer compared with the intermediate and deep layers. Versican density was lower in the lamina propria of women compared with men; this difference was noted in the superficial layer only. There was a positive correlation between collagen type III and versican densities within the lamina propria. Conclusion: Collagen type I, collagen type III, and versican are distributed differently within the lamina propria layers of the adult vocal folds.
  • article 57 Citação(ões) na Scopus
    Study of the Nasoseptal Flap for Endoscopic Anterior Cranial Base Reconstruction
    (2011) PINHEIRO-NETO, Carlos D.; RAMOS, Henrique F.; PERIS-CELDA, Maria; FERNANDEZ-MIRANDA, Juan C.; GARDNER, Paul A.; SNYDERMAN, Carl H.; SENNES, Luiz U.
    Objectives/Hypothesis: Measure the dimensions of the nasoseptal (NS) flap and the anterior skull base (ASB) defect. Verify whether the flap is sufficient to cover the defect. Study the anatomy of the septal artery (SA). Study Design: Anatomical and radiological study. Methods: After endoscopic craniofacial resection, sufficiency of the flap to cover the ASB defect was assessed. The SA was dissected. The number of branches in the pedicle and the distance between the artery and the sphenoid ostium were noted. Radiologic study analyzing CT scans of 30 patients for comparison among measurements of the NS flap and the ASB defect was performed. Results: In all cases the flap was sufficient to cover the ASB. Two branches of the SA were found in the pedicle in 71.4%. The distance between the SA and the sphenoid ostium was 9.3 mm. The reconstruction area of the flap (17.12 cm(2)) was larger than the defect area (8.64 cm(2)) (P < .001). The difference between the superior length of the flap and the anterior-posterior distance of the defect was <= 5 mm in 26.7%. Comparison between the anterior flap width and the anterior defect width revealed that in 33% the difference was <= 5 mm. Conclusions: The dimensions of NS flap are sufficient to cover completely the ASB defect. The anterior edge of the defect presents increased risk for failure in coverage. Additional width adding the nasal floor mucosa to the flap is important to decrease the risk of gap in the anterior orbit-orbit defect. It is more common to find two branches of the SA in the pedicle.
  • article 4 Citação(ões) na Scopus
    Angiofibroma Nasofaríngeo Juvenil com extensão intradural
    (2011) RAMOS, Henrique Faria; TAKAHASHI, Marystella Tomoe; RAMOS, Bernardo Faria; GOMES, Marcos de Queiroz Teles; SENNES, Luiz Ubirajara