LUIZ UBIRAJARA SENNES

(Fonte: Lattes)
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Lattes
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Unidades Organizacionais
Departamento de Otorrinolaringologia e Oftalmologia, Faculdade de Medicina - Docente
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/63, Hospital das Clínicas, Faculdade de Medicina
LIM/32 - Laboratório de Otorrinolaringologia, Hospital das Clínicas, Faculdade de Medicina - Líder

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  • article 0 Citação(ões) na Scopus
    Bipedicled Vocal Fold Mucosal Flap: An Experimental Study
    (2022) KINCHOKU, Vanessa Mika; IMAMURA, Rui; HACHIYA, Adriana; YAMASAKI, Rosiane; SENNES, Luiz Ubirajara; TSUJI, Domingos Hiroshi
    Objective. To determine the dimensions of mucosal defects that can be covered by a bipedicled vocal fold mucosal flap.Methods. We used 20 adults human larynges (10 of each gender) excised from cadavers, divided into 2 groups of 10 larynges (5 of each gender) each. In one group (the normal flap group), we created the largest possible bipedicled vocal fold mucosal flap and then quantified the dimensions of the largest defect that could be covered by displacing the flap medially. In the other group (the augmented flap group), the flap was augmented laterally with mucosa from the laryngeal ventricle and we determined whether the larger flap would effectively cover larger defects.Results. The mean width of mucosal defect capable of being covered was 1.51 mm when the normal bipedicled flap was employed and was 1.67 mm when the augmented flap was applied. However, the difference was not sta-tistically significant. We found that defect size correlated with vocal fold length, width and flap size in the normal flap group, whereas it correlated only with vocal fold length in the augmented flap group. The bipedicled flap is capable of covering larger defects in males.Conclusion. Enlargement of a bipedicled vocal fold mucosal flap with laryngeal ventricular mucosa does not necessarily translate to an increase in the size of defect that can be covered. On average, the flap should be 30% larger than the width of the defect. The statistical model for predicting the defect size based on the vocal fold length, vocal fold width, and flap size has excellent predictive quality when a normal flap is employed.
  • conferenceObject
    Treatment of Sleep Disordered Breathing with Leptin Loaded Extracellular Vesicles
    (2022) FREIRE, Carla; PHO, Huv; RAMSEV, Jacob D.; ZHAO, Yuling; KIM, Lenise J.; BERGER, Slava; ANOKYE-DANSO, Frederick; SENNES, Luiz U.; AHIMA, Rexford S.; BATRAKOVA, Elena V.; KABANOV, Alexander V.; POLOTSKY, Vsevolod Y.