SERGIO PODGAEC
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular, Hospital das Clínicas, Faculdade de Medicina
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular, Hospital das Clínicas, Faculdade de Medicina
9 resultados
Resultados de Busca
Agora exibindo 1 - 9 de 9
bookPart Dor pélvica crônica(2013) FAGUNDES, Paula Zulian; FERNANDES, Luiz Flávio Cordeiro; PODGAEC, Sergio; ABRãO, Maurício Simões- Surgical Therapies: Pouch of Douglas and Uterovaginal Pouch Resection for Endometriosis(2012) ABRãO, M.S.; PODGAEC, S.; FERNANDES, L.F.C
bookPart Endometriose - aspectos imunológicos e moleculares(2014) FERNANDES, Luiz Flávio Cordeiro; PODGAEC, Sérgio; ABRãO, Maurício SimõesbookPart Endometriose: tratamento cirúrgico(2016) FERNANDES, Luiz Flávio Cordeiro; PODGAEC, Sérgio; BELLELIS, Patrick; JúNIOR, João Antônio Dias; ABRãO, Maurício SimõesbookPart Endometriose: diagnóstico(2016) FERNANDES, Luiz Flávio Cordeiro; JúNIOR, João Antônio Dias; PODGAEC, Sérgio; ABRãO, Maurício Simões- CD4+CD25highFoxp3+Cells Increased in the Peritoneal Fluid of Patients with Endometriosis(2012) PODGAEC, Sergio; RIZZO, Luiz Vicente; FERNANDES, Luiz Flavio Cordeiro; BARACAT, Edmund Chada; ABRAO, Mauricio SimoesProblem To evaluate CD4+CD25highFoxp3+ cells and IL-6, IL-10, IL-17, and TGF-beta in the peritoneal fluid of women with endometriosis. Method of study A total of ninety-eight patients were studied: endometriosis (n = 70) and control (n = 28). First, peritoneal fluid lymphocytes were isolated, and CD4+CD25high cells were identified using flow cytometry. Then, RT-PCR was performed to verify Foxp3 expression in these cells. Also, IL-6, IL-10, IL-17, and TGF-beta concentration was determined. Results Of all the lymphocytes in the peritoneal fluid of women with endometriosis, 36.5% (median) were CD4+CD25high compared to only 1.15% (median) in the control group (P < 0.001). Foxp3 expression was similarly elevated in patients with the disease compared to those without (median, 50 versus 5; P < 0.001). IL-6 and TGF-beta were higher in endometriosis group (IL-6: 327.5 pg/mL versus 195.5 pg/mL; TGF-beta: 340 pg/mL versus 171.5 pg/mL; both P < 0.001). IL-10 and IL-17 showed no significant differences between the two groups. Conclusion The peritoneal fluid of patients with endometriosis had a higher percentage of CD4+CD25highFoxp3+ cells and also higher levels of IL-6 and TGF-beta compared to women without the disease. These findings suggest that CD4+CD25highFoxp3+ cells may play a role in the pathogenesis of endometriosis.
bookPart Dor pélvica crônica(2016) HENRIQUE, Luiz Fernando de Oliveira; FAGUNDES, Paula Zulian; FERNANDES, Luiz Flávio Cordeiro; JúNIOR, João Antônio Dias; PODGAEC, Sérgio; ABRãO, Maurício SimõesbookPart Endometriose ovariana(2013) FERNANDES, Luiz Flávio Cordeiro; PODGAEC, Sergio; ABRãO, Maurício SimõesbookPart Endometriose: tratamento clínico(2016) GIBRAN, Luciano; BELLELIS, Patrick; FERNANDES, Luiz Flávio Cordeiro; PODGAEC, Sérgio; ABRãO, Maurício Simões