SERGIO PODGAEC
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular, Hospital das Clínicas, Faculdade de Medicina
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular, Hospital das Clínicas, Faculdade de Medicina
8 resultados
Resultados de Busca
Agora exibindo 1 - 8 de 8
- Polymorphisms of ICAM-1 and IL-6 genes related to endometriosis in a sample of Brazilian women(2016) BESSA, Nathalie Zamagni; FRANCISCO, Daniela de Oliveira; ANDRES, Marina de Paula; GUEUVOGHLANIAN-SILVA, Barbara Yasmim; PODGAEC, Sergio; FRIDMAN, CintiaThis study investigated the possibility of K469E (rs5498) and G241R (rs1799969) polymorphisms, in ICAM-1 gene, and G634C (rs1800796), in IL-6 gene, being associated with the occurrence of endometriosis in a sample of Brazilian women. We genotyped 200 women (100 in control group and 100 in endometriosis group) by PCR-RFLP technique for G634C, K469E, and G241R polymorphisms. No significant difference was observed in genotypic frequency between control and endometriosis groups for G634C and K469E polymorphisms (p = 0.61 and p = 0.22, respectively). In addition, no significant difference between stages I-II and III-IV of the disease was found for both SNPs (p = 0.63 and p = 0.24, respectively). All individuals were wild homozygotes for G241R polymorphism. This study suggests that polymorphisms K469E, G241R, and G634C are not associated with increased susceptibility to endometriosis in Brazilian women.
- Protocol of randomized controlled trial of potentized estrogen in homeopathic treatment of chronic pelvic pain associated with endometriosis(2016) TEIXEIRA, Marcus Zulian; PODGAEC, Sergio; BARACAT, Edmund ChadaBackground: Endometriosis is a chronic inflammatory disease that causes difficult-to treat pelvic pain. Thus being, many patients seek help in complementary and alternative medicine, including homeopathy. The effectiveness of homeopathic treatment for endometriosis is controversial due to the lack of evidences in the literature. The aim of the present randomized controlled trial is to assess the efficacy of potentized estrogen compared to placebo in the treatment of chronic pelvic pain associated with endometriosis. Methods/design: The present is a randomized, double-blind, placebo-controlled trial of a homeopathic medicine individualized according to program 'New Homeopathic Medicines: use of modern drugs according to the principle of similitude' (http://newhomeopathicmedicines.com). Women with endometriosis, chronic pelvic pain and a set of signs and symptoms similar to the adverse events caused by estrogen were recruited at the Endometriosis Unit of Division of Clinical Gynecology, Clinical Hospital, School of Medicine, University of Sao Paulo (Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo - HCFMUSP). The participants were selected based on the analysis of their medical records and the application of self-report structured questionnaires. A total of 50 women meeting the eligibility criteria will be randomly allocated to receive potentized estrogen or placebo. The primary clinical outcome measure will be severity of chronic pelvic pain. Statistical analysis will be performed on the intention-to-treat and per-protocol approaches comparing the effect of the homeopathic medicine versus placebo after 24 weeks of intervention. Discussion: The present study was approved by the research ethics committee of HCFMUSP and the results are expected in 2016.
bookPart Adenomiose: diagnóstico e tratamento(2016) BORRELLI, Giuliano Moisés; MYUNG, Lidia; CARAçA, Daniel; PODGAEC, Sérgio; ABRãO, Maurício SimõesbookPart Endometriose: tratamento cirúrgico(2016) FERNANDES, Luiz Flávio Cordeiro; PODGAEC, Sérgio; BELLELIS, Patrick; JúNIOR, João Antônio Dias; ABRãO, Maurício SimõesbookPart Endometriose: diagnóstico(2016) FERNANDES, Luiz Flávio Cordeiro; JúNIOR, João Antônio Dias; PODGAEC, Sérgio; ABRãO, Maurício SimõesbookPart Dor pélvica crônica(2016) HENRIQUE, Luiz Fernando de Oliveira; FAGUNDES, Paula Zulian; FERNANDES, Luiz Flávio Cordeiro; JúNIOR, João Antônio Dias; PODGAEC, Sérgio; ABRãO, Maurício Simões- A systematic review of ultrasonography-guided transvaginal aspiration of recurrent ovarian endometrioma(2016) GONCALVES, Fernanda C.; ANDRES, Marina P.; PASSMAN, Leigh J.; GONCALVES, Manoel O. C.; PODGAEC, SergioBackground: Ovarian endometriosis is present in 17%-44% of women with endometriosis. The main treatment is surgery, but ultrasonography-guided aspiration is a less invasive alternative. Objectives: To evaluate the effectiveness of this alternative treatment in recurrent ovarian endometrioma. Search strategy: Multiple databases were searched for articles published between 1994 and 2014 using the keywords ""ultrasound-guided aspiration,"" ""ovarian,"" and ""endometriosis."" Selection criteria: Randomized controlled trials and observational studies published in English, Portuguese, or Spanish were included. Data collection and analysis: Two researchers independently extracted and reviewed the data. The main outcome of interest was the recurrence rate. Main results: Eight studies were eligible. Ovarian endometriosis is associated with high recurrence rates after one ultrasonography-guided aspiration (28.9%-91.5%), but involves less ovarian manipulation. The results of aspiration followed by sclerotherapy are not uniform, but overall the addition of a sclerosing agent does not seem to significantly reduce the likelihood of recurrence (13.3%-75.0%). Repeated aspiration of the cysts can reduce the recurrence rate to 5.4% by the sixth aspiration. Conclusions: Repeated ultrasonography-guided aspiration of ovarian endometriomas can be performed for the treatment of recurrent ovarian endometriosis. Further studies comparing the efficacy of this procedure and ovarian surgery are needed.
bookPart Endometriose: tratamento clínico(2016) GIBRAN, Luciano; BELLELIS, Patrick; FERNANDES, Luiz Flávio Cordeiro; PODGAEC, Sérgio; ABRãO, Maurício Simões