FABIO FERNANDES MORATO CASTRO
Projetos de Pesquisa
Unidades Organizacionais
FM, Faculdade de Medicina
Departamento de Clínica Médica, Faculdade de Medicina - Docente
LIM/60 - Laboratório de Imunologia Clínica e Alergia, Hospital das Clínicas, Faculdade de Medicina - Líder
Departamento de Clínica Médica, Faculdade de Medicina - Docente
LIM/60 - Laboratório de Imunologia Clínica e Alergia, Hospital das Clínicas, Faculdade de Medicina - Líder
4 resultados
Resultados de Busca
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- Eosinophilic Esophagitis: Latent Disease in Patients with Anaphylactic Reaction to Cow's Milk(2018) BARBOSA, Adriana C.; CASTRO, Fabio Morato; MEIRELES, Paula Rezende; ARRUDA, L. Karla; CARDOSO, Silvia Regina; KALIL, Jorge; YANG, Ariana C.BACKGROUND: Food allergy and eosinophilic esophagitis are a substantial and evolving public health issue. Clinicians should know the relationship between these diseases and how one may predispose to the other. This can help minimize misdiagnosis. OBJECTIVE: The objective of this study was to assess esophageal eosinophilia and eosinophilic esophagitis frequency in patients with persistent cow's milk allergy and anaphylaxis manifestations. METHODS: Patients with persistent cow's milk allergy with anaphylaxis manifestations were enrolled from 2012 through 2016 at the Sao Paulo University Hospital, Brazil. All of them were submitted to endoscopy despite the presence or absence of gastrointestinal symptoms. Demographics data, atopic comorbidities, medication use, endoscopic findings, and esophageal eosinophilia frequency were evaluated. RESULTS: Eighty-nine patients were selected. The median age was 8 years. It was observed that 34 of 89 patients (38.2%; 95% confidence interval [CI]: 28.14%-49.16%) presented with esophageal eosinophilia. Five patients (7.1%) presented proton pump inhibitor-responsive esophageal eosinophilia, and 10 patients (14.2%) presented eosinophilic esophagitis. We found that 29.4% were asymptomatic patients, 23.5% had nonspecific symptoms, 23.5% had persistent typical symptoms, and 23.5% had intermittent typical symptoms. There was an association with inflammatory endoscopy findings in 21 patients (61.7%). CONCLUSIONS: This description demands scientific attention because it is the highest frequency of esophageal eosinophilia yet described in a group of patients with cow's milk allergy presenting with anaphylaxis. Eosinophilic esophagitis is a condition that can coexist ""silently"" with an IgE-mediated food allergy and is most often underestimated and under-diagnosed. (C) 2017 American Academy of Allergy, Asthma & Immunology
bookPart Alergia e Imunologia Clínica(2018) CASTRO, Fábio Fernandes Morato; MACEDO, Priscilla Rios Cordeiro; CROCE, Júlio- Hereditary Angioedema with Normal C1 Inhibitor and F12 Mutations in 42 Brazilian Families(2018) VERONEZ, Camila Lopes; MORENO, Adriana S.; CONSTANTINO-SILVA, Rosemeire Navickas; MAIA, Luana S. M.; FERRIANI, Mariana P. L.; CASTRO, Fabio F. M.; VALLE, Solange Rodrigues; NAKAMURA, Victor Koji; CAGINI, Nathalia; GONCALVES, Rozana Fatima; MANSOUR, Eli; SERPA, Faradiba Sarquis; DIAS, Gabriela Andrade Coelho; PICCIRILLO, Miguel Alberto; TOLEDO, Eliana; BERNARDES, Marli de Souza; CICHON, Sven; STIEBER, Christiane; ARRUDA, L. Karla; PESQUERO, Joao Bosco; GRUMACH, Anete SevciovicBACKGROUND: Hereditary angioedema (HAE) with normal C1 inhibitor (C1-INH) is a rare condition with clinical features similar to those of HAE with C1-INH deficiency. Mutations in the F12 gene have been identified in subsets of patients with HAE with normal C1-INH, mostly within families of European descent. OBJECTIVES: Our aim was to describe clinical characteristics observed in Brazilians from 42 families with HAE and F12 gene mutations (FXII-HAE), and to compare these findings with those from other populations. METHODS: We evaluated a group of 195 individuals, which included 102 patients clinically diagnosed with FXII-HAE and their 93 asymptomatic relatives. RESULTS: Genetic analysis revealed that of the 195 subjects, 134 individuals (77.6% females) carried a pathogenic mutation in F12. The T328K substitution was found in 132 individuals, and the c.971_1018 + 24del72 deletion was found in 2 patients. The mean age at onset of symptoms in patients with FXII-HAE was 21.1 years. The most common symptoms were subcutaneous edema (85.8% of patients), abdominal pain attacks (69.7%), and upper airway edema (32.3%). Of male individuals carrying F12 mutations, 53.3% (16 of 30) were symptomatic. Compared with reports from Europe, fewer female patients (68.6%) reported an influence of estrogen on symptoms. CONCLUSIONS: Our study included a large number of patients with FXII-HAE, and, as the first such study conducted in a South American population, it highlighted significant differences between this and other study populations. The high number of symptomatic males and patients with estrogen-independent FXII-HAE found here suggests that male sex and the absence of a hormonal influence should not discourage clinicians from searching for F12 mutations in cases of HAE with normal C1-INH. (C) 2017 American Academy of Allergy, Asthma & Immunology.
- IV Brazilian Consensus on Rhinitis - an update on allergic rhinitis(2018) SAKANO, Eulalia; SARINHO, Emanuel S. C.; CRUZ, Alvaro A.; PASTORINO, Antonio C.; TAMASHIRO, Edwin; KUSCHNIR, Fabio; CASTRO, Fabio F. M.; ROMANO, Fabrizio R.; WANDALSEN, Gustavo F.; CHONG-NETO, Herberto J.; MELLO JR., Joao F. de; SILVA, Luciana R.; RIZZO, Maria Candida; MIYAKE, Monica A. M.; ROSARIO FILHO, Nelson A.; RUBINI, Norma de Paula M.; MION, Olavo; CAMARGOS, Paulo A.; ROITHMANN, Renato; GODINHO, Ricardo N.; PIGNATARI, Shirley Shizue N.; SIH, Tania; ANSELMO-LIMA, Wilma T.; SOLE, DirceuIntroduction: The guidelines on allergic rhinitis aim to update knowledge about the disease and care for affected patients. The initiative called ""Allergic Rhinitis and its Impact on Asthma"", initially published in 2001 and updated in 2008 and 2010, has been very successful in disseminating information and evidence, as well as providing a classification of severity and proposing a systemized treatment protocol. In order to include the participation of other medical professionals in the treatment of allergic rhinitis, it is important to develop algorithms that accurately indicate what should and can be done regionally. Objective: To update the III Brazilian Consensus on Rhinitis - 2012, with the creation of an algorithm for allergic rhinitis management. Methods: We invited 24 experts nominated by the Brazilian Association of Allergy and Immunology, Brazilian Association of Otorhinolaryngology and Head and Neck Surgery and Brazilian Society of Pediatrics to update the 2012 document. Results: The update of the last Brazilian Consensus on Rhinitis incorporated and adapted the relevant information published in all ""Allergic Rhinitis and its Impact on Asthma"" Initiative documents to the Brazilian scenario, bringing new concepts such as local allergic rhinitis, new drugs and treatment evaluation methods. Conclusion: A flowchart for allergic rhinitis treatment has been proposed. (C) 2017 Published by Elsevier Editora Ltda. on behalf of Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial.