FABIO FERNANDES MORATO CASTRO
Projetos de Pesquisa
Unidades Organizacionais
FM, Faculdade de Medicina
Departamento de Clínica Médica, Faculdade de Medicina - Docente
LIM/60 - Laboratório de Imunologia Clínica e Alergia, Hospital das Clínicas, Faculdade de Medicina - Líder
Departamento de Clínica Médica, Faculdade de Medicina - Docente
LIM/60 - Laboratório de Imunologia Clínica e Alergia, Hospital das Clínicas, Faculdade de Medicina - Líder
10 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 10
conferenceObject Clinical evolution of Kaposi's varicelliform eruption using Immunosuppressive drugs as treatment for atopic dermatitis(2020) PACHANI, M. A. D. S.; ZANETTI, F. A.; BIALOWAS, D.; NUNES, S. A.; LOPES, M. M.; MARTINS, C. R. S.; CASTRO, F. F. M.; KALIL, J.; YANG, A. C.conferenceObject In vitro NLRP3 inflammasome activation assay assists diagnosis of genetically negative CAPS patients and guides anti-IL1 therapy(2020) MENDONCA, L. O.; TOLEDO-BARROS, M. A. M.; FRANCO, P. A.; GIAVINA-BIANCHI JUNIOR, P. F.; KALIL, J. E.; CASTRO, F. F. Morato; CAROLI, F.; GROSSI, A.; CECCHERINI, I; ROBAZZI, T.; PILEGGI, G. S.; RIVITTI, M. C.; SANCHES JUNIOR, J. A.; GRUMACH, A. S.; GATTORNO, M.; PONTILLO, A.conferenceObject Delayed diagnosis of eosinophilic esophagitis in patients with cow's milk allergy IgE mediated(2020) PEREIRA, G. D. F.; CORDOVA, P. T. C.; FRANCO, P. D. A.; GOMES, L. S.; MAMEDE, L. D. Q.; PEREZ, I. L.; ARAUJO, A. A. M. F. E. S.; CASTRO, F. F. M.; YANG, A. C.- Mathematical model describing CoViD-19 in Sao Paulo, Brazil - evaluating isolation as control mechanism and forecasting epidemiological scenarios of release(2020) YANG, H. M.; LOMBARDI JUNIOR, L. P.; CASTRO, F. F. M.; YANG, A. C.In Sao Paulo, Brazil, the first case of coronavirus disease 2019 (CoViD-19) was confirmed on 26 February, the first death due to CoViD-19 was registered on 16 March, and on 24 March, Sao Paulo implemented the isolation of persons in non-essential activities. A mathematical model was formulated based on non-linear ordinary differential equations considering young (60 years old or less) and elder (60 years old or more) subpopulations, aiming to describe the introduction and dissemination of the new coronavirus in Sao Paulo. This deterministic model used the data collected from Sao Paulo to estimate the model parameters, obtainingR(0)= 6.8 for the basic reproduction number. The model also allowed to estimate that 50% of the population of Sao Paulo was in isolation, which permitted to describe the current epidemiological status. The goal of isolation implemented in Sao Paulo to control the rapid increase of the new coronavirus epidemic was partially succeeded, concluding that if isolation of at least 80% of the population had been implemented, the collapse in the health care system could be avoided. Nevertheless, the isolated persons must be released one day. Based on this model, we studied the potential epidemiological scenarios of release by varying the proportions of the release of young and elder persons. We also evaluated three different strategies of release: All isolated persons are released simultaneously, two and three releases divided in equal proportions. The better scenarios occurred when young persons are released, but maintaining elder persons isolated for a while. When compared with the epidemic without isolation, all strategies of release did not attain the goal of reducing substantially the number of hospitalisations due to severe CoViD-19. Hence, we concluded that the best decision must be postponing the beginning of the release.
conferenceObject Endoscopic patterns and complications of eosinophilic esophagitis(2020) GOMES, L. S.; CORDOVA, P. T.; MAMEDE, L. Q.; PEREIRA, G. F.; SOUZA, A. B.; KALIL, J.; CASTRO, F. F. M.; YANG, A. C.conferenceObject Clinical, genetic and therapeutical findings of two Brazilian patients with cutaneous mastocytosis associated with systemic autoinflammation(2020) MENDONCA, L. O.; PEREIRA, G. D. F.; FRANCO, P. A.; TOLEDO-BARROS, M. A. M.; AGONDI, R. C.; MORATO-CASTRO, F. F.; CAROLI, F.; GROSSI, A.; CECCHERINI, I; PONTILLO, A.; KALIL, J. E.; GATTORNO, M.; GIAVINA-BIANCHI JUNIOR, P. F.conferenceObject Delayed diagnosis of Eosinophilic Esophagitis in patients with IgE-mediated cow's milk allergy(2020) PEREIRA, Grazielly; TORRES, Pablo; FRANCO, Priscila; ANAGUSKO, Claudia; CASTRO, Fabio; YANG, Ariana- A case report of a novel compound heterozygous mutation in a Brazilian patient with deficiency of Interleukin-1 receptor antagonist (DIRA)(2020) MENDONCA, Leonardo Oliveira; GROSSI, Alice; CAROLI, Francesco; OLIVEIRA, Robson Aguiar de; KALIL, Jorge; CASTRO, Fabio Fernandes Morato; PONTILLO, Alessandra; CECCHERINI, Isabella; BARROS, Myrthes Anna Maragna Toledo; GATTORNO, MarcoBackground Deficiency of the natural antagonist of interleukin-1 was first described in 2009 and so far 20 patients has been reported. In Brazil just two cases have been reported both carrying the same homozygous 15 bp deletion. Blocking interleukin-1 has changed rate survival for DIRA patients. The use of anakinra and rilonacept has been reported safe and efficient, whereas the selective blockade of interleukin-1 beta, using the monoclonal antibody canakinumab has been reported in a single case only. Case presentation Here we report a case of a 7 years old Brazilian boy that presented with recurrent episodes of systemic inflammation with severe disabling osteomyelitis with mild pustular skin rash. A Next Generation Sequencing gene panel allowed to detect two pathogenic mutations in the IL1RN gene, described in compound heterozygosity. Corticosteroids was effective in controlling inflammation and anti-IL1 beta blocker triggered disease flare. Complete clinical control could be achieved using IL-1 receptor antagonist. Conclusions DIRA is a severe, life threatening autoinflammatory condition with low numbers of patients described all over the world. The mutation p.Asp72_Ile76del in IL1RN is presented in all Brazilian DIRA patients already described and p.Q45* (rs1019766125) is a new mutation affecting the IL1RN gene. Following the pathogenesis of DIRA, blocking both subunits of interleukin one as well as antagonizing the receptor using anakinra or rilonacept seems to be effective. There is just one report using canakinumab for the treatment of DIRA and this is the first report of disease flare using this drug.
- Immunophenotypical Characterization of a Brazilian POIS (Post-Orgasmic Illness Syndrome) Patient: Adding More Pieces to Puzzle(2020) AMICIS, Karine De; COSTA, Priscilla Ramos; FIGO, Daniele Danella; LIMA, Cynthia Mafra Fonsecade De; CASTRO, Fabio Fernandes Morato; KALIL, Jorge; SANTOS, Keity Souza; GALVAO, Clovis Eduardo SantosPost-orgasmic illness syndrome (POIS) is a rare condition characterized by post-ejaculatory symptoms. Here is reported the first Brazilian POIS patient. Immunological investigation did not confirm the previous hypothesis of a hypersensitivity reaction. Cell immunophenotyping comparing healthy individuals produced evidence of abnormalities not associated to clinical manifestations. The patient was submitted to specific immunotherapy with transient clinical response and was referred to a psychologist but did not demonstrate clinical improvement of symptoms. Therefore, etiology of POIS remains unclear.
conferenceObject Is IgA a piece of the EoE puzzle?(2020) MARTINS, C. S. F.; SUPRUN, M.; CUNHA, P. S.; SANTOS, K. S.; GUIMARAES, J. M.; CASTRO, F. F. M.; GRISHINA, G.; YANG, A. C.; SAMPSON, H. A.