FABIO FERNANDES MORATO CASTRO
Projetos de Pesquisa
Unidades Organizacionais
FM, Faculdade de Medicina
Departamento de Clínica Médica, Faculdade de Medicina - Docente
LIM/60 - Laboratório de Imunologia Clínica e Alergia, Hospital das Clínicas, Faculdade de Medicina - Líder
Departamento de Clínica Médica, Faculdade de Medicina - Docente
LIM/60 - Laboratório de Imunologia Clínica e Alergia, Hospital das Clínicas, Faculdade de Medicina - Líder
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conferenceObject Systemic inflammatory syndromes with immunodysregulatory phenotype: clinical characteristics, genetic findings and therapeutic response(2021) PEREIRA, Grazielly Pereira; PRADO, Alex; BRANDAO, Jaqueline Brandao; ZANETTI, Francine Zanetti; ALBERTO, Nazoneth; ALBERTO, Samucanda; KALIL, Jorge; FONSECA, Luiz; CASTRO, Fabio Castro; TOLEDO-BARROS, Myrthes; MENDONCA, Leonardo Mendonca- Evaluating the impacts of relaxation and mutation in the SARS-CoV-2 on the COVID-19 epidemic based on a mathematical model: a case study of Sao Paulo State (Brazil)(2021) YANG, Hyun Mo; LOMBARDI JUNIOR, Luis Pedro; CASTRO, Fabio Fernandes Morato; YANG, Ariana CamposAt the beginning of 2020, SARS-CoV-2 spread to all continents, and many countries adopted quarantine to flatten the COVID-19 outbreak, resulting in the containment of transmission. However, the persistent transmission of SARS-CoV-2, an RNA virus, resulted in the appearance of mutations in the original virus. The appearance of more virulent mutations in different regions of the world resulted in an increased number of severe COVID-19 cases. A mathematical model based on the COVID-19 natural history encompassing the mutations was applied to evaluate the SARS-CoV-2 epidemic. The model parameters were fitted against the observed data from Sao Paulo State (Brazil) considering quarantine, relaxation, and mutation. The estimated data from Sao Paulo State showed that the original SARS-CoV-2 transmission better explained the COVID-19 epidemic during the quarantine. However, the increased number of fatalities beyond that predicted by the relaxation indicated the occurrence of mutations. Hence, the relaxation in association with the transmission of a more virulent SARS-CoV-2 better estimated the COVID-19 epidemic from February 26, 2020, to June 15, 2021, in Sao Paulo State.
bookPart Rinossinusites(2021) MORAES, Priscila; GALVãO, Clóvis Eduardo Santos; CASTRO, Fabio Fernandes Morato- Mathematical modeling of the transmission of SARS-CoV-2-Evaluating the impact of isolation in SAo Paulo State (Brazil) and lockdown in Spain associated with protective measures on the epidemic of CoViD-19(2021) YANG, Hyun Mo; LOMBARDI JUNIOR, Luis Pedro; CASTRO, Fabio Fernandes Morato; YANG, Ariana CamposCoronavirus disease 2019 (CoViD-19), with the fatality rate in elder (60 years old or more) being much higher than young (60 years old or less) patients, was declared a pandemic by the World Health Organization on March 11, 2020. A mathematical model considering young and elder subpopulations under different fatality rates was formulated based on the natural history of CoViD-19 to study the transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The model considered susceptible, exposed, asymptomatic, pre-symptomatic, mild CoViD-19, severe CoViD-19, and recovered compartments, besides compartments of isolated individuals and those who were caught by test. This model was applied to study the epidemiological scenario resulting from the adoption of quarantine (isolation or lockdown) in many countries to control the rapid propagation of CoViD-19. We chose as examples the isolation adopted in SAo Paulo State (Brazil) in the early phase but not at the beginning of the epidemic, and the lockdown implemented in Spain when the number of severe CoViD-19 cases was increasing rapidly. Based on the data collected from SAo Paulo State and Spain, the model parameters were evaluated, and we obtained a higher estimation for the basic reproduction number R-0 (9.24 for SAo Paulo State, and 8 for Spain) compared to the currently accepted estimation of R-0 around 2 using the SEIR (susceptible, exposed, infectious, and recovered compartments) model. In comparison with the lockdown in Spain, the relatively early adoption of the isolation in SAo Paulo State resulted in enlarging the period of the first wave of the epidemic and delaying its peak. The model allowed to explain the flattening of the epidemic curves by quarantine when associated with the protective measures (face mask, washing hands with alcohol and gel, and social distancing) adopted by the population. The description of the epidemic under quarantine and protections can be a background to foreseen the epidemiological scenarios from the release strategies, which can help guide public health policies by decision-makers.
- Immunological repertoire linked to PSTPIP1-associated myeloid-related inflammatory (PAMI) syndrome(2021) MENDONCA, Leonardo Oliveira; TERRERI, Maria Teresa; OSAKU, Fabiane Mitie; BARROS, Samar Freschi; KOHLER, Karen Francine; PRADO, Alex Isidoro; BARROS, Myrthes Toledo; KALIL, Jorge; CASTRO, Fabio Fernandes MoratoBackground Mutations along PSTPIP1 gene are associated to two specific conditions, PAPA syndrome and PAMI syndrome, both autoinflammatory disorders associated to disturbances in cytoskeleton formation. Immunological aspects of PAMI syndrome has not yet been reported neither the clinical impact on therapeutical decisions. Methods Clinical data of patients records were retrospectively accessed. Genomic DNA were extracted and sequenced following standard procedures. Peripheral lymphocytes were quantified in T, B e FOXP3 phenotypes. Results We describe two related patients with PAMI syndrome harboring the usual E250K mutation. Anti-IL1 therapy could partially control the disease in the index patient. A broad spectrum of immunological effects as well as an aberrant expression of FOXP3 could be observed. Conclusions Here we report two related brazilian patients with PAMI syndromes harboring the E250K mutation in PSTPIP1, their immunological aspects and the therapeutical response to canakinumab.
bookPart Reações alérgicas causadas por venenos de hymenoptera(2021) WATANABE, Alexandra Sayuri; CASTRO, Fabio Fernandes Morato- Case Report: Expanding Clinical, Immunological and Genetic Findings in Sideroblastic Anemia With Immunodeficiency, Fevers and Development Delay (SIFD) Syndrome(2021) MENDONCA, Leonardo Oliveira; PRADO, Alex Isidoro; COSTA, Izelda Maria Carvalho; BANDEIRA, Marcia; DYER, Rafael; BARROS, Samar Freschi; KHOLER, Karen Francine; FONSECA, Luiz Augusto Marcondes; KALIL, Jorge; CASTRO, Fabio Morato; TOLEDO-BARROS, Myrthes Anna MaragnaSince the first description of the syndrome of sideroblastic anemia with immunodeficiency, fevers and development delay (SIFD), clinical pictures lacking both neurological and hematological manifestations have been reported. Moreover, prominent skin involvement, such as with relapsing erythema nodosum, is not a common finding. Up to this moment, no genotype and phenotype correlation could be done, but mild phenotypes seem to be located in the N or C part. B-cell deficiency is a hallmark of SIFD syndrome, and multiple others immunological defects have been reported, but not high levels of double negative T cells. Here we report a Brazilian patient with a novel phenotype of SFID syndrome, carrying multiple immune defects and harboring a novel mutation on TRNT1 gene.