FABIO FERNANDES MORATO CASTRO
Projetos de Pesquisa
Unidades Organizacionais
FM, Faculdade de Medicina
Departamento de Clínica Médica, Faculdade de Medicina - Docente
LIM/60 - Laboratório de Imunologia Clínica e Alergia, Hospital das Clínicas, Faculdade de Medicina - Líder
Departamento de Clínica Médica, Faculdade de Medicina - Docente
LIM/60 - Laboratório de Imunologia Clínica e Alergia, Hospital das Clínicas, Faculdade de Medicina - Líder
34 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 34
- The international survey on the management of allergic rhinitis by physicians and patients (ISMAR)(2015) BAENA-CAGNANI, Carlos E.; CANONICA, Giorgio W.; HELAL, Mohamed Zaky; GOMEZ, Rene Maximiliano; COMPALATI, Enrico; ZERNOTTI, Mario E.; SANCHEZ-BORGES, Mario; CASTRO, Fabio F. Morato; AGUTTES, Margarita Murrieta; LOPEZ-GARCIA, Aida; TADROS, Faheem A.Epidemiologic studies suggest that the prevalence of allergic rhinitis (AR) is rising worldwide. Several reports, in fact, indicate increasing trends in the prevalence of AR especially in developing countries, likely related to the environment and climate changes and the adoption of an urbanized Western lifestyle. The primary objective of the present study was to collect information about management in real-life settings, including a characterization of typical patients' profile referring to physicians, the disease features, the common approaches to diagnostic assessments and therapeutic decisions. This was an international, multicenter, cross-sectional study conducted in adults or children (>= 6 years) suffering from rhinitis confirmed by physician's diagnosis for at least one year. The 234 physicians who participated in the study included a total of 2778 patients in Egypt, Mexico, Brazil, Colombia, Guatemala, Iran, Venezuela, Argentina, Israel, Kuwait and United Arab Emirates. It was found that clinical history was the selected tool to diagnose and categorize AR patients (97.1%), with less than half of patients undergoing allergy testing, may be explaining the scarce use of immunotherapy on management of disease. Out of 2776 patients, 93.4% had somehow received a recommendation to avoid allergens and irritant agent exposure. Notably, 91.4% were receiving at least one treatment at the time of the survey, mostly oral antihistamines (79.7%) and intranasal corticosteroids (66.3%). Oral antihistamines, intranasal steroids and decongestants were considered both safe and effective by patients and physicians, preferring oral and nasal route of administration. The ISMAR registry was designed according to the most accepted epidemiological recommendations, and provides interesting information regarding the management of rhinitis from a patient and physician points of view, with many similarities between the participating countries. Further efforts are required to better manage AR and its comorbidities.
conferenceObject Deep remission in eosinophilic esophagitis: Looking beyond eosinophils(2019) MAMEDE, L. De Queiroz; TORRES, P.; GOMES, L. Souza; CASTRO, F. Morato; YANG, A. C.conferenceObject Clinical evolution of Kaposi's varicelliform eruption using Immunosuppressive drugs as treatment for atopic dermatitis(2020) PACHANI, M. A. D. S.; ZANETTI, F. A.; BIALOWAS, D.; NUNES, S. A.; LOPES, M. M.; MARTINS, C. R. S.; CASTRO, F. F. M.; KALIL, J.; YANG, A. C.- Eosinophilic Esophagitis: Latent Disease in Patients with Anaphylactic Reaction to Cow's Milk(2018) BARBOSA, Adriana C.; CASTRO, Fabio Morato; MEIRELES, Paula Rezende; ARRUDA, L. Karla; CARDOSO, Silvia Regina; KALIL, Jorge; YANG, Ariana C.BACKGROUND: Food allergy and eosinophilic esophagitis are a substantial and evolving public health issue. Clinicians should know the relationship between these diseases and how one may predispose to the other. This can help minimize misdiagnosis. OBJECTIVE: The objective of this study was to assess esophageal eosinophilia and eosinophilic esophagitis frequency in patients with persistent cow's milk allergy and anaphylaxis manifestations. METHODS: Patients with persistent cow's milk allergy with anaphylaxis manifestations were enrolled from 2012 through 2016 at the Sao Paulo University Hospital, Brazil. All of them were submitted to endoscopy despite the presence or absence of gastrointestinal symptoms. Demographics data, atopic comorbidities, medication use, endoscopic findings, and esophageal eosinophilia frequency were evaluated. RESULTS: Eighty-nine patients were selected. The median age was 8 years. It was observed that 34 of 89 patients (38.2%; 95% confidence interval [CI]: 28.14%-49.16%) presented with esophageal eosinophilia. Five patients (7.1%) presented proton pump inhibitor-responsive esophageal eosinophilia, and 10 patients (14.2%) presented eosinophilic esophagitis. We found that 29.4% were asymptomatic patients, 23.5% had nonspecific symptoms, 23.5% had persistent typical symptoms, and 23.5% had intermittent typical symptoms. There was an association with inflammatory endoscopy findings in 21 patients (61.7%). CONCLUSIONS: This description demands scientific attention because it is the highest frequency of esophageal eosinophilia yet described in a group of patients with cow's milk allergy presenting with anaphylaxis. Eosinophilic esophagitis is a condition that can coexist ""silently"" with an IgE-mediated food allergy and is most often underestimated and under-diagnosed. (C) 2017 American Academy of Allergy, Asthma & Immunology
conferenceObject Systemic inflammatory syndromes with immunodysregulatory phenotype: clinical characteristics, genetic findings and therapeutic response(2021) PEREIRA, Grazielly Pereira; PRADO, Alex; BRANDAO, Jaqueline Brandao; ZANETTI, Francine Zanetti; ALBERTO, Nazoneth; ALBERTO, Samucanda; KALIL, Jorge; FONSECA, Luiz; CASTRO, Fabio Castro; TOLEDO-BARROS, Myrthes; MENDONCA, Leonardo MendoncaconferenceObject Inflammatory cell response, functional and biochemical features of the airways of professional cleaning workers upon exposure in the workplace(2017) LIMA, Cynthia F. Mafra; SARAIVA, Beatriz M.; KALIL, Jorge; CASTRO, Fabio M.; GALVAO, Clovis Eduardo S.conferenceObject In vitro NLRP3 inflammasome activation assay assists diagnosis of genetically negative CAPS patients and guides anti-IL1 therapy(2020) MENDONCA, L. O.; TOLEDO-BARROS, M. A. M.; FRANCO, P. A.; GIAVINA-BIANCHI JUNIOR, P. F.; KALIL, J. E.; CASTRO, F. F. Morato; CAROLI, F.; GROSSI, A.; CECCHERINI, I; ROBAZZI, T.; PILEGGI, G. S.; RIVITTI, M. C.; SANCHES JUNIOR, J. A.; GRUMACH, A. S.; GATTORNO, M.; PONTILLO, A.conferenceObject Safety to Extensively Heated Cow's Milk Challenge in Children with Severe Cow's Milk Allergy(2017) CORDOVA, Pablo Torres; PEDROSO, Natalia Falci; MELLO, Marcella Fonseca; SALLES-CUNHA, Patricia; KALIL, Jorge; CASTRO, Fabio M.; YANG, Ariana CamposconferenceObject Delayed diagnosis of eosinophilic esophagitis in patients with cow's milk allergy IgE mediated(2020) PEREIRA, G. D. F.; CORDOVA, P. T. C.; FRANCO, P. D. A.; GOMES, L. S.; MAMEDE, L. D. Q.; PEREZ, I. L.; ARAUJO, A. A. M. F. E. S.; CASTRO, F. F. M.; YANG, A. C.conferenceObject Eosinophilic esophagitis: Association with atopic diseases and IgE mediated food allergy(2019) TORRES, P.; ZANANDREA, A.; PENIDO, A.; MOUCO, C.; ASSIS, J. P. De; CASTRO, F. F. M.; YANG, A. C.