JOSE LEONIDAS ALVES JUNIOR
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina - Médico
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
6 resultados
Resultados de Busca
Agora exibindo 1 - 6 de 6
- Pulmonary Hypertension in General Cardiology Practice(2019) CALDERARO, Daniela; ALVES JUNIOR, Jose Leonidas; FERNANDES, Caio Julio Cesar dos Santos; SOUZA, RogerioThe finding of pulmonary hypertension (PH) by echocardiography is common and of concern. However, echocardiography is just a suggestive and non-diagnostic assessment of PH. When direct involvement of pulmonary circulation is suspected, invasive hemodynamic monitoring is recommended to establish the diagnosis. This assessent provides, in addition to the diagnostic confirmation, the correct identification of the vascular territory predominantly involved (arterial pulmonary or postcapillary). Treatment with specific medication for PH (phosphodiesterase type 5 inhibitors, endothelin receptor antagonists and prostacyclin analogues) has been proven effective in patients with pulmonary arterial hypertension, but its use in patients with PH due to left heart disease can even be damaging. In this review, we discuss the diagnosis criteria, how etiological investigation should be carried out, the clinical classification and, finally, the therapeutic recommendations for PH.
- Cancer-associated thrombosis: the when, how and why(2019) FERNANDES JR., Caio J.; MORINAGA, Luciana T. K.; ALVES, Jose L.; CASTRO, Marcela A.; CALDERARO, Daniela; JARDIM, Carlos V. P.; SOUZA, RogerioCancer-associated thrombosis (CAT) is a condition in which relevance has been increasingly recognised both for physicians that deal with venous thromboembolism (VTE) and for oncologists. It is currently estimated that the annual incidence of VTE in patients with cancer is 0.5% compared to 0.1% in the general population. Active cancer accounts for 20% of the overall incidence of VTE. Of note, VTE is the second most prevalent cause of death in cancer, second only to the progression of the disease, and cancer is the most prevalent cause of deaths in VTE patients. Nevertheless, CAT presents several peculiarities that distinguish it from other VTE, both in pathophysiology mechanisms, risk factors and especially in treatment, which need to be considered. CAT data will be reviewed in this review.
- Pulmonary Hypertension in Pulmonary Langerhans Cell Histiocytosis: prevalence and the role of Cardiopulmonary Exercise Testing and echocardiogram in predicting it(2019) HEIDEN, Glaucia Itamaro; SOBRAL, Juliana Barbosa; ALVES JR., Jose Leonidas; SALGE, Joao Marcos; ALBUQUERQUE, Andre Luis; FERNANDES, Caio Julio Cesar; KAIRALLA, Ronaldo; CARVALHO, Carlos Roberto Ribeiro; SOUZA, Rogerio; BALDI, Bruno Guedes
- Platelets and chronic thromboembolic pulmonary hypertension(2019) OLIVEIRA, Talita; KATO-MORINAGA, Luciana; ASSAD, Ana; OLIVEIRA, Ellen; JARDIM, Carlos; ALVES- JR., Jose; SOUZA, Rogerio; FERNANDES, Caio Julio Cesar
article Reflections on the use of thrombolytic agents in acute pulmonary embolism(2019) FERNANDES, Caio Julio Cesar dos Santos; JARDIM, Carlos Vianna Poyares; ALVES JR., Jose Leonidas; OLEAS, Francisca Alexandra Gavilanes; MORINAGA, Luciana Tamie Kato; SOUZA, Rogerio de- Pulmonary Embolism and Gas Exchange(2019) FERNANDES, Caio J.; ASSAD, Ana Paula Luppino; ALVES- JR., Jose L.; JARDIM, Carlos; SOUZA, Rogerio deAcute pulmonary embolism (PE) impairs hemodynamics, gas exchange, and lung mechanical capacity. Considering PE pathophysiology, most attention has been paid to hemodynamic impairment. However, the most prevalent symptoms in PE patients come from gas exchange alterations, which have not been in the spotlight for many years. Pulmonary physiology and consequent gas exchange impairment play a pivotal role in the high risk of death from PE. In this review, we will look at the pathophysiology of PE, from the vascular occlusion to the resultant heterogeneity in pulmonary perfusion and gas exchange impairment, discussing in detail its causes and consequences.