MARCELO LOQUETTE DAMASCENO
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article 2 Citação(ões) na Scopus FUNCTIONAL AND HISTOLOGIC EVALUATION OF HYPERBARIC OXYGEN THERAPY IN RATS WITH SPINAL CORD INJURY(2011) GALVAO, Paulo Eduardo de Carvalho; CRISTANTE, Alexandre Fogaca; JORGE, Henrique Mennucci de Haidar; DAMASCENO, Marcelo Loquette; MARCON, Raphael Martus; OLIVEIRA, Reginaldo Perillo; BARROS FILHO, Tarcisio Eloy Pessoa deObjective: To evaluate the effectiveness of the application of hyperbaric oxygen therapy in Wistar rats with spinal cord contusion produced using computerized equipment to create impact by a falling weight, NYU Impactor. Methods: We evaluated 17 male rats with weights ranging from 265 to 426 g; impacts were performed with a weight of 10 g from a predetermined height of 12.5 mm, at the tenth thoracic vertebra, after completion of prior laminectomy. The rats were randomly divided into a control group and a group treated with hyperbaric oxygen. The latter, was treated with oxygen therapy in a hyperbaric chamber for one hour daily for a period of 30 days. The assessment of locomotor recovery was conducted on the 2nd, 9th, 16th, 23rd and 30th postoperative days, measured by the functional scale and the site of injury submitted to anatomopathological examination. Results: Improved locomotor recovery was demonstrated in the rats treated with hyperbaric oxygen in the initial stages of the evaluation, but at the end of the evaluation there was no statistically significant difference between the two groups. The anatomopathological examination showed structural changes of the spinal cord in both groups. Conclusion: Spinal cord injury in rats evolved differently in the hyperbaric oxygen therapy group compared with the control group, in the initial phase.- Prevalence of scoliosis in Williams-Beuren syndrome patients treated at a regional reference center(2014) DAMASCENO, Marcelo Loquette; CRISTANTE, Alexandre Fogaca; MARCON, Raphael Martus; BARROS FILHO, Tarcisio Eloy Pessoa deOBJECTIVE: This study assessed the prevalence of scoliosis and the patterns of scoliotic curves in patients with Williams-Beuren syndrome. Williams-Beuren syndrome is caused by a chromosome 7q11.23 deletion in a region containing 28 genes, with the gene encoding elastin situated approximately at the midpoint of the deletion. Mutation of the elastin gene leads to phenotypic changes in patients, including neurodevelopmental impairment of varying degrees, characteristic facies, cardiovascular abnormalities, hypercalcemia, urological dysfunctions, and bone and joint dysfunctions. METHODS: A total of 41 patients diagnosed with Williams-Beuren syndrome, who were followed up at the genetics ambulatory center of a large referral hospital, were included in the study. There were 25 male subjects. The patients were examined and submitted to radiographic investigation for Cobb angle calculation. RESULTS: It was observed that 14 patients had scoliosis; of these 14 patients, 10 were male. The pattern of deformity in younger patients was that of flexible and simple curves, although adults presented with double and triple curves. Statistical analysis showed no relationships between scoliosis and age or sex. CONCLUSION: This study revealed a prevalence of scoliosis in patients with Williams-Beuren syndrome of 34.1%; however, age and sex were not significantly associated with scoliosis or with the severity of the curves.
article 11 Citação(ões) na Scopus SPINAL CORD INJURY EXPERIMENTAL MODEL AND MOTION EVALUATION PROTOCOL IN WISTAR RATS(2011) SANTOS, Gustavo Bispo dos; CRISTANTE, Alexandre Fogaca; MARCON, Raphael Martus; SOUZA, Fabiano Inacio de; BARROS FILHO, Tarcisio Eloy Pessoa de; DAMASCENO, Marcelo LoquetteObjectives: To determine a standardized spinal cord contusion model and a method for motor assessment in rats with paraplegia. Methods: This study used 20 Wistar rats divided into 4 groups according to level of severity of spinal cord injury; standardized intermediate lesions were made through system MASCIS IMPACTOR (Multicenter Animal Spinal Cord Injury Study): group 1, 12.5mm (mild injury); group 2,25mm (moderate injury); group 3,50mm (severe injury; in the group 4 the animals suffered no injury (control group). Motor function was assessed after 48 hours, using the scale proposed by Basso, Beattie and Bresnahan. Results: Using the model, we observed that the mild contusions (12.5mm height) were effective, and the animals presented acute urinary tract infection one week after the injury. Moderate contusions (25mm height) were effective, and the animals presented urinary infection until 2 weeks after injury. The severe contusions (50mm height) were effective, and the animals presented urinary infection for 3 to 4 weeks and autophagy. Conclusion: The model of spinal cord injury using the system MASCIS IMPACTOR and the functional assessment proposed by Basso, Beattie and Bresnahan is reproducible and can be used, enabling information exchange among different researchers.- Evaluation of the effects of hyperbaric oxygen therapy for spinal cord lesion in correlation with the moment of intervention(2012) CRISTANTE, A. F.; DAMASCENO, M. L.; BARROS FILHO, T. E. P.; OLIVEIRA, R. P. de; MARCON, R. M.; ROCHA, I. D. daStudy design: Experimental, controlled, animal study. Objectives: To evaluate the functional effect of hyperbaric oxygen therapy administered shortly, one day after, and no intervention (control) in standardized experimental spinal cord lesions in Wistar rats. Setting: Sao Paulo, Brazil. Methods: In all, 30 Wistar rats with spinal cord lesions were divided into three groups: one group was submitted to hyperbaric oxygen therapy beginning half an hour after the lesion and with a total of 10 one-hour sessions, one session per day, at 2 atm; the second received the same treatment, but beginning on the day after the lesion; and the third received no treatment (control). The Basso, Beattie and Bresnahan scales were used for functional evaluation on the second day after the lesion and then weekly, until being killed 1 month later. Results: There were no significant differences between the groups in the functional analysis on the second day after the lesion. There was no functional difference comparing Groups 1 and 2 (treated shortly after or one day after) in any evaluation moment. On the 7th day, as well as on the 21st and 28th postoperative days, the evaluation showed that Groups 1 and 2 performed significantly better than the control group (receiving no therapy). Conclusion: Hyperbaric chamber therapy is beneficial in the functional recovery of spinal cord lesions in rats, if it is first administered just after spinal cord injury or within 24 h. Spinal Cord (2012) 50, 502-506; doi: 10.1038/sc.2012.16; published online 6 March 2012
article 9 Citação(ões) na Scopus TREATMENT OF ODONTOID FRACTURES(2011) PONTIN, Pedro Augusto; BUMLAI, Renam Urt Mansur; LETAIF, Olavo Biraghi; DAMASCENO, Marcelo Loquette; CRISTANTE, Alexandre Fogaca; MARCON, Raphael Martus; IUTAKA, Alexandre Sadao; OLIVEIRA, Reginaldo Perilo; BARROS FILHO, Tarcisio Eloy Pessoa deObjective: This article describes a clinical and radiologic retrospective analysis of odontoid fractures in 20 patients accompanied by the IOT-HCFMUSP, from 2004 to 2010. Methods: These fractures were stratified according to their classification (AO/Anderson and D'Alonzo), epidemiologic profile, type of treatment, time to consolidation of the fracture, and complications. Results: It was observed that there was a higher number of odontoid fractures in males (4: 1), between the third and fourth decades of life (60%), and that the main causes of the trauma were falling from heights (60%) and car accidents (25%). Also, 15% of the cases presented neurological deficits. The most prevalent type of odontoid fracture was Type II (55%) followed by Type III (40%). The most prevalent type of treatment used for Type II and III fractures was surgical (73%) and non-surgical (87.5%), respectively. Consolidation of the fracture took place within 16 weeks in 87.5% of surgically treated cases, and in 54.5% of those treated non-surgically. No cases of pseudoarthrosis were found. Conclusion: The surgical treatment of Type II odontoid fractures showed satisfactory results in relation to time to consolidation of the fracture and low incidence of complications, as did the non-surgical treatment used for the Type III fractures. Level of Evidence: Level IV, case series.