JOAO RICARDO SATO
Projetos de Pesquisa
Unidades Organizacionais
LIM/44 - Laboratório de Ressonância Magnética em Neurorradiologia, Hospital das Clínicas, Faculdade de Medicina
17 resultados
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Agora exibindo 1 - 10 de 17
conferenceObject Treatment Response Prediction in Pediatric Patients With OCD Using Structural Neuroimaging Correlates: Simple Linear Regression Versus Support Vector Regression(2017) VATTIMO, Edoardo; BARROS, Vivian; BATISTUZZO, Marcelo; REQUENA, Guaraci; SATO, Joao; FATORI, Daniel; SHAVITT, Roseli; MIGUEL, Euripedes; HOEXTER, Marcelo- Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta-and Mega-Analysis (vol , pg , 2016)(2017) ABE, Yoshinari; ALONSO, Pino; AMEIS, Stephanie H.; ARNOLD, Paul D.; BARGALLO, Nuria; BATISTUZZO, Marcelo C.; BENEDETTI, Francesco; BEUCKE, Jan C.; BOEDHOE, Premika S. W.; BOLLETTINI, Irene; BOSE, Anushree; BREM, Silvia; BUSATTO, Geraldo F.; CALVO, Anna; CALVO, Rosa; CATH, Danielle C.; CHENG, Yuqi; CHO, Kang Ik K.; DALLASPEZIA, Sara; VRIES, Froukje E. de; WIT, Stella J. de; DENYS, Damiaan; FANG, Yu; FITZGERALD, Kate D.; FONTAINE, Martine; FOUCHE, Jean-Paul; GIMENEZ, Monica; GRUNER, Patricia; HANNA, Gregory L.; HIBAR, Derrek P.; HOEXTER, Marcelo Q.; HU, Hao; HUYSER, Chaim; IKARI, Keisuke; JAHANSHAD, Neda; KATHMANN, Norbert; KAUFMANN, Christian; KHADKA, Sabin; KOCH, Kathrin; KWON, Jun Soo; LAZARO, Luisa; LIU, Yanni; LOCHNER, Christine; MARSH, Rachel; MARTINEZ-ZALACAIN, Ignacio; MATAIX-COLS, David; MENCHON, Jose M.; MIGUEL, Euripedes C.; MINUZZI, Luciano; MORER, Astrid; NAKAMAE, Takashi; NAKAO, Tomohiro; NARAYANASWAMY, Janardhanan C.; PIRAS, Fabrizio; PIRAS, Federica; PITTENGER, Christopher; REDDY, Y. C. Janardhan; SATO, Joao R.; SIMPSON, H. Blair; SCHMAAL, Lianne; SORENI, Noam; SORIANO-MAS, Carles; SPALLETTA, Gianfranco; STEIN, Dan J.; STEVENS, Michael C.; SZESZKO, Philip R.; THOMPSON, Paul M.; TOLIN, David F.; VELTMAN, Dick J.; VENKATASUBRAMANIAN, Ganesan; HEUVEL, Odile A. van den; WERF, Ysbrand D. van der; WINGEN, Guido A. van; WALITZA, Susanne; WANG, Zhen; XU, Jian; XU, Xiufeng; YUN, Je-Yeon; ZHAO, Qing
- Associations between children's family environment, spontaneous brain oscillations, and emotional and behavioral problems(2019) SATO, Joao Ricardo; JR, Claudinei Eduardo Biazoli; SALUM, Giovanni Abrahao; GADELHA, Ary; CROSSLEY, Nicolas; VIEIRA, Gilson; ZUGMAN, Andre; PICON, Felipe Almeida; PAN, Pedro Mario; HOEXTER, Marcelo Queiroz; JR, Edson Amaro; ANES, Mauricio; MOURA, Luciana Monteiro; DEL'AQUILLA, Marco Antonio Gomes; MCGUIRE, Philip; ROHDEZ, Luis Augusto; MIGUEL, Euripedes Constantino; BRESSAN, Rodrigo Affonseca; JACKOWSKI, Andrea ParolinThe family environment in childhood has a strong effect on mental health outcomes throughout life. This effect is thought to depend at least in part on modifications of neurodevelopment trajectories. In this exploratory study, we sought to investigate whether a feasible resting-state fMRI metric of local spontaneous oscillatory neural activity, the fractional amplitude of low-frequency fluctuations (fALFF), is associated with the levels of children's family coherence and conflict. Moreover, we sought to further explore whether spontaneous activity in the brain areas influenced by family environment would also be associated with a mental health outcome, namely the incidence of behavioral and emotional problems. Resting-state fMRI data from 655 children and adolescents (6-15years old) were examined. The quality of the family environment was found to be positively correlated with fALFF in the left temporal pole and negatively correlated with fALFF in the right orbitofrontal cortex. Remarkably, increased fALFF in the temporal pole was associated with a lower incidence of behavioral and emotional problems, whereas increased fALFF in the orbitofrontal cortex was correlated with a higher incidence.
- Multicenter Voxel-Based Morphometry Mega-Analysis of Structural Brain Scans in Obsessive-Compulsive Disorder(2014) WIT, Stella J. de; ALONSO, Pino; SCHWEREN, Lizanne; MATAIX-COLS, David; LOCHNER, Christine; MENCHON, Jose M.; STEIN, Dan J.; FOUCHE, Jean-Paul; SORIANO-MAS, Caries; SATO, Joao R.; HOEXTER, Marcelo Q.; DENYS, Damiaan; NAKAMAE, Takashi; NISHIDA, Seiji; KWON, Jun Soo; JANG, Joon Hwan; BUSATTO, Geraldo F.; CARDONER, Narcis; CATH, Danielle C.; FUKUI, Kenji; JUNG, Wi Hoon; KIM, Sung Nyun; MIGUEL, Euripides C.; NARUMOTO, Jin; PHILLIPS, Mary L.; PUJOL, Jesus; REMIJNSE, Peter L.; SAKAI, Yuki; SHIN, Na Young; YAMADA, Kei; VELTMAN, Dick J.; HEUVEL, Odile A. van denObjective: Results from structural neuroimaging studies of obsessive-compulsive disorder (OCD) have been only partially consistent. The authors sought to assess regional gray and white matter volume differences between large samples of OCD patients and healthy comparison subjects and their relation with demographic and clinical variables. Method: A multicenter voxel-based morphometry mega-analysis was performed on 1.5-T str.uctural T-1-weighted MRI scans derived from the International OCD Brain Imaging Consortium. Regional gray and white matter brain volumes were compared between 412 adult OCD patients and 368 healthy subjects. Results: Relative to healthy comparison subjects, OCD patients had significantly smaller volumes of frontal gray and white matter bilaterally, including the dorsomedial prefrontal cortex, the anterior cingulate cortex, and the inferior frontal gyrus extending to the anterior insula. Patients also showed greater cerebellar gray matter volume bilaterally compared with healthy subjects. Group differences in frontal gray and white matter volume were significant after correction for multiple comparisons. Additionally, group-by-age interactions were observed in the putamen, insula, and orbitofrontal cortex (indicating relative preservation of volume in patients compared with healthy subjects with increasing age) and in the temporal cortex bilaterally (indicating a relative loss of volume in patients compared. with healthy subjects with increasing age). Conclusions: These findings partially support the prevailing fronto-striatal models of OCD and offer additional insights into the neuroanatomy of the disorder that were not apparent from previous smaller studies. The group-by-age interaction effects. in orbitofrontal-striatal and (para)limbic brain regions may be the result of altered neuroplasticity associated with chronic compulsive behaviors, anxiety, or compensatory processes related to cognitive dysfunction.
- Temporal Stability of Network Centrality in Control and Default Mode Networks: Specific Associations with Externalizing Psychopathology in Children and Adolescents(2015) SATO, Joao Ricardo; BIAZOLI JR., Claudinei Eduardo; SALUM, Giovanni Abrahao; GADELHA, Ary; CROSSLEY, Nicolas; SATTERTHWAITE, Theodore D.; VIEIRA, Gilson; ZUGMAN, Andre; PICON, Felipe Almeida; PAN, Pedro Mario; HOEXTER, Marcelo Queiroz; ANES, Mauricio; MOURA, Luciana Monteiro; DEL'AQUILLA, Marco Antonio Gomes; AMARO JR., Edson; MCGUIRE, Philip; LACERDA, Acioly L. T.; ROHDE, Luis Augusto; MIGUEL, Euripedes Constantino; JACKOWSKI, Andrea Parolin; BRESSAN, Rodrigo AffonsecaAbnormal connectivity patterns have frequently been reported as involved in pathological mental states. However, most studies focus on ""static,"" stationary patterns of connectivity, which may miss crucial biological information. Recent methodological advances have allowed the investigation of dynamic functional connectivity patterns that describe non-stationary properties of brain networks. Here, we introduce a novel graphical measure of dynamic connectivity, called time-varying eigenvector centrality (tv-EVC). In a sample 655 children and adolescents (7-15 years old) from the Brazilian ""High Risk Cohort Study for Psychiatric Disorders"" who were imaged using resting-state fMRI, we used this measure to investigate age effects in the temporal in control and default-mode networks (CN/DMN). Using support vector regression, we propose a network maturation index based on the temporal stability of tv-EVC. Moreover, we investigated whether the network maturation is associated with the overall presence of behavioral and emotional problems with the Child Behavior Checklist. As hypothesized, we found that the tv-EVC at each node of CN/DMN become more stable with increasing age (P < 0.001 for all nodes). In addition, the maturity index for this particular network is indeed associated with general psychopathology in children assessed by the total score of Child Behavior Checklist (P = 0.027). Moreover, immaturity of the network was mainly correlated with externalizing behavior dimensions. Taken together, these results suggest that changes in functional network dynamics during neurodevelopment may provide unique insights regarding pathophysiology. (C) 2015 Wiley Periodicals, Inc.
- White matter microstructure and its relation to clinical features of obsessive-compulsive disorder: findings from the ENIGMA OCD Working Group(2021) PIRAS, Fabrizio; PIRAS, Federica; ABE, Yoshinari; AGARWAL, Sri Mahavir; ANTICEVIC, Alan; AMEIS, Stephanie; ARNOLD, Paul; BANAJ, Nerisa; BARGALLO, Nuria; BATISTUZZO, Marcelo C.; BENEDETTI, Francesco; BEUCKE, Jan-Carl; BOEDHOE, Premika S. W.; BOLLETTINI, Irene; BREM, Silvia; CALVO, Anna; CHO, Kang Ik Kevin; CIULLO, Valentina; DALLASPEZIA, Sara; DICKIE, Erin; ELY, Benjamin Adam; FAN, Siyan; FOUCHE, Jean-Paul; GRUNER, Patricia; GUERSEL, Deniz A.; HAUSER, Tobias; HIRANO, Yoshiyuki; HOEXTER, Marcelo Q.; IORIO, Mariangela; JAMES, Anthony; REDDY, Y. C. Janardhan; KAUFMANN, Christian; KOCH, Kathrin; KOCHUNOV, Peter; KWON, Jun Soo; LAZARO, Luisa; LOCHNER, Christine; MARSH, Rachel; NAKAGAWA, Akiko; NAKAMAE, Takashi; NARAYANASWAMY, Janardhanan C.; SAKAI, Yuki; SHIMIZU, Eiji; SIMON, Daniela; SIMPSON, Helen Blair; SORENI, Noam; STAEMPFLI, Philipp; STERN, Emily R.; SZESZKO, Philip; TAKAHASHI, Jumpei; VENKATASUBRAMANIAN, Ganesan; WANG, Zhen; YUN, Je-Yeon; STEIN, Dan J.; JAHANSHAD, Neda; THOMPSON, Paul M.; HEUVEL, Odile A. van den; SPALLETTA, Gianfranco; ASSOGNA, Francesca; CALVO, Rosa; WIT, Stella J. de; HOUGH, Morgan; KUNO, Masaru; MIGUEL, Euripedes C.; MORER, Astrid; PITTENGER, Christopher; POLETTI, Sara; SMERALDI, Enrico; SATO, Joao R.; TSUCHIYAGAITO, Aki; WALITZA, Susanne; WERF, Ysbrand D. van der; VECCHIO, Daniela; ZAREI, MojtabaMicrostructural alterations in cortico-subcortical connections are thought to be present in obsessive-compulsive disorder (OCD). However, prior studies have yielded inconsistent findings, perhaps because small sample sizes provided insufficient power to detect subtle abnormalities. Here we investigated microstructural white matter alterations and their relation to clinical features in the largest dataset of adult and pediatric OCD to date. We analyzed diffusion tensor imaging metrics from 700 adult patients and 645 adult controls, as well as 174 pediatric patients and 144 pediatric controls across 19 sites participating in the ENIGMA OCD Working Group, in a cross-sectional case-control magnetic resonance study. We extracted measures of fractional anisotropy (FA) as main outcome, and mean diffusivity, radial diffusivity, and axial diffusivity as secondary outcomes for 25 white matter regions. We meta-analyzed patient-control group differences (Cohen's d) across sites, after adjusting for age and sex, and investigated associations with clinical characteristics. Adult OCD patients showed significant FA reduction in the sagittal stratum (d=-0.21, z=-3.21, p=0.001) and posterior thalamic radiation (d=-0.26, z=-4.57, p<0.0001). In the sagittal stratum, lower FA was associated with a younger age of onset (z=2.71, p=0.006), longer duration of illness (z=-2.086, p=0.036), and a higher percentage of medicated patients in the cohorts studied (z=-1.98, p=0.047). No significant association with symptom severity was found. Pediatric OCD patients did not show any detectable microstructural abnormalities compared to controls. Our findings of microstructural alterations in projection and association fibers to posterior brain regions in OCD are consistent with models emphasizing deficits in connectivity as an important feature of this disorder.
bookPart Métodos de investigação em neuroimagem(2021) BATISTUZZO, Marcelo Camargo; OTADUY, Maria Concepción García; HOEXTER, Marcelo Queiroz; SATO, João Ricardo- Decreased centrality of subcortical regions during the transition to adolescence: A functional connectivity study(2015) SATO, Joao Ricardo; SALUM, Giovanni Abrahao; GADELHA, Ary; VIEIRA, Gilson; ZUGMAN, Andre; PICON, Felipe Almeida; PAN, Pedro Mario; HOEXTER, Marcelo Queiroz; ANES, Mauricio; MOURA, Luciana Monteiro; DEL'AQUILLA, Marco Antonio Gomes; CROSSLEY, Nicolas; AMARO JUNIOR, Edson; MCGUIRE, Philip; LACERDA, Acioly L. T.; ROHDE, Luis Augusto; MIGUEL, Euripedes Constantino; JACKOWSKI, Andrea Parolin; BRESSAN, Rodrigo AffonsecaInvestigations of brain maturation processes are a key step to understand the cognitive and emotional changes of adolescence. Although structural imaging findings have delineated clear brain developmental trajectories for typically developing individuals, less is known about the functional changes of this sensitive development period. Developmental changes, such as abstract thought, complex reasoning, and emotional and inhibitory control, have been associated with more prominent cortical control. The aim of this study is to assess brain networks connectivity changes in a large sample of 7- to 15-year-old subjects, testing the hypothesis that cortical regions will present an increasing relevance in commanding the global network. Functional magnetic resonance imaging (fMRI) data were collected in a sample of 447 typically developing children from a Brazilian community sample who were submitted to a resting state acquisition protocol. The fMRI data were used to build a functional weighted graph from which eigenvector centrality (EVC) was extracted. For each brain region (a node of the graph), the age-dependent effect on EVC was statistically tested and the developmental trajectories were estimated using polynomial functions. Our findings show that angular gyrus become more central during this maturation period, while the caudate; cerebellar tonsils, pyramis, thalamus; fusiform, parahippocampal and inferior semilunar lobe become less central. In conclusion, we report a novel finding of an increasing centrality of the angular gyrus during the transition to adolescence, with a decreasing centrality of many subcortical and cerebellar regions.
- Association between abnormal brain functional connectivity in children and psychopathology: A study based on graph theory and machine learning(2018) SATO, Joao Ricardo; BIAZOLI JR., Claudinei Eduardo; SALUM, Giovanni Abrahao; GADELHA, Ary; CROSSLEY, Nicolas; VIEIRA, Gilson; ZUGMAN, Andre; PICON, Felipe Almeida; PAN, Pedro Mario; HOEXTER, Marcelo Queiroz; AMARO JR., Edson; ANES, Mauricio; MOURA, Luciana Monteiro; DEL'AQUILLA, Marco Antonio Gomes; MCGUIRE, Philip; ROHDE, Luis Augusto; MIGUEL, Euripedes Constantino; JACKOWSKI, Andrea Parolin; BRESSAN, Rodrigo AffonsecaObjectives: One of the major challenges facing psychiatry is how to incorporate biological measures in the classification of mental health disorders. Many of these disorders affect brain development and its connectivity.In this study, we propose a novel method for assessing brain networks based on the combination of a graph theory measure (eigenvector centrality) and a one-class support vector machine (OC-SVM).Methods: We applied this approach to resting-state fMRI data from 622 children and adolescents. Eigenvector centrality (EVC) of nodes from positive- and negative-task networks were extracted from each subject and used as input to an OC-SVM to label individual brain networks as typical or atypical. We hypothesised that classification of these subjects regarding the pattern of brain connectivity would predict the level of psychopathology.Results: Subjects with atypical brain network organisation had higher levels of psychopathology (p<0.001). There was a greater EVC in the typical group at the bilateral posterior cingulate and bilateral posterior temporal cortices; and significant decreases in EVC at left temporal pole.Conclusions: The combination of graph theory methods and an OC-SVM is a promising method to characterise neurodevelopment, and may be useful to understand the deviations leading to mental disorders.
conferenceObject Orbitofrontal Thickness as a Measure for Treatment Response Classification in Obsessive-Compulsive Disorder(2014) HOEXTER, Marcelo; DINIZ, Juliana; LOPES, Antonio; BATISTUZZO, Marcelo; SHAVITT, Roseli; DOUGHERTY, Darin; DURAN, Fabio; BRESSAN, Rodrigo; BUSATTO, Geraldo; MIGUEL, Euripedes; SATO, Joao