JOAO RICARDO SATO
Projetos de Pesquisa
Unidades Organizacionais
LIM/44 - Laboratório de Ressonância Magnética em Neurorradiologia, Hospital das Clínicas, Faculdade de Medicina
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conferenceObject Treatment Response Prediction in Pediatric Patients With OCD Using Structural Neuroimaging Correlates: Simple Linear Regression Versus Support Vector Regression(2017) VATTIMO, Edoardo; BARROS, Vivian; BATISTUZZO, Marcelo; REQUENA, Guaraci; SATO, Joao; FATORI, Daniel; SHAVITT, Roseli; MIGUEL, Euripedes; HOEXTER, Marcelo- Stroke lesion in cortical neural circuits and post-stroke incidence of major depressive episode: A 4-month prospective study(2011) TERRONI, Luisa; AMARO JR., Edson; IOSIFESCU, Dan V.; TINONE, Gisela; SATO, Joao Ricardo; LEITE, Claudia Costa; SOBREIRO, Matildes F. M.; LUCIA, Mara Cristina Souza; SCAFF, Milberto; FRAGUAS, RenerioObjective. Little is known about the relevance of lesion in neural circuits reported to be associated with major depressive disorder. We investigated the association between lesion stroke size in the limbic-cortical-striatal-pallidal-thalamic (LCSPT) circuit and incidence of major depressive episode (MDE). Methods. We enrolled 68 patients with first-ever ischemic stroke and no history of major depressive disorder. Neurological and psychiatric examinations were performed at three time-points. We diagnosed major depressive episode, following DSM-IV criteria. Lesion location and volume were determined with magnetic resonance imaging, using a semi-automated method based on the Brodmann Cytoarchitectonic Atlas. Results. Twenty-one patients (31%) experienced major depressive episode. Larger lesions in the left cortical regions of the LCSPT circuit (3,760 vs. 660 mm(3); P = 0.004) were associated with higher incidence of MDE. Secondary analyses revealed that major depressive episode was associated with larger lesions in areas of the medial prefrontal cortex including the ventral (BA24) and dorsal anterior cingulate cortex (BA32) and subgenual cortex (BA25); and also the subiculum (BA28/36) and amygdala (BA34). Conclusions Our findings indicate that depression due to stroke is aetiologically related to the disruption of the left LCSPT circuit and support the relevance of the medial prefrontal cortex dysfunction in the pathophysiology of depression.
- Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta-and Mega-Analysis (vol , pg , 2016)(2017) ABE, Yoshinari; ALONSO, Pino; AMEIS, Stephanie H.; ARNOLD, Paul D.; BARGALLO, Nuria; BATISTUZZO, Marcelo C.; BENEDETTI, Francesco; BEUCKE, Jan C.; BOEDHOE, Premika S. W.; BOLLETTINI, Irene; BOSE, Anushree; BREM, Silvia; BUSATTO, Geraldo F.; CALVO, Anna; CALVO, Rosa; CATH, Danielle C.; CHENG, Yuqi; CHO, Kang Ik K.; DALLASPEZIA, Sara; VRIES, Froukje E. de; WIT, Stella J. de; DENYS, Damiaan; FANG, Yu; FITZGERALD, Kate D.; FONTAINE, Martine; FOUCHE, Jean-Paul; GIMENEZ, Monica; GRUNER, Patricia; HANNA, Gregory L.; HIBAR, Derrek P.; HOEXTER, Marcelo Q.; HU, Hao; HUYSER, Chaim; IKARI, Keisuke; JAHANSHAD, Neda; KATHMANN, Norbert; KAUFMANN, Christian; KHADKA, Sabin; KOCH, Kathrin; KWON, Jun Soo; LAZARO, Luisa; LIU, Yanni; LOCHNER, Christine; MARSH, Rachel; MARTINEZ-ZALACAIN, Ignacio; MATAIX-COLS, David; MENCHON, Jose M.; MIGUEL, Euripedes C.; MINUZZI, Luciano; MORER, Astrid; NAKAMAE, Takashi; NAKAO, Tomohiro; NARAYANASWAMY, Janardhanan C.; PIRAS, Fabrizio; PIRAS, Federica; PITTENGER, Christopher; REDDY, Y. C. Janardhan; SATO, Joao R.; SIMPSON, H. Blair; SCHMAAL, Lianne; SORENI, Noam; SORIANO-MAS, Carles; SPALLETTA, Gianfranco; STEIN, Dan J.; STEVENS, Michael C.; SZESZKO, Philip R.; THOMPSON, Paul M.; TOLIN, David F.; VELTMAN, Dick J.; VENKATASUBRAMANIAN, Ganesan; HEUVEL, Odile A. van den; WERF, Ysbrand D. van der; WINGEN, Guido A. van; WALITZA, Susanne; WANG, Zhen; XU, Jian; XU, Xiufeng; YUN, Je-Yeon; ZHAO, Qing
- Associations between children's family environment, spontaneous brain oscillations, and emotional and behavioral problems(2019) SATO, Joao Ricardo; JR, Claudinei Eduardo Biazoli; SALUM, Giovanni Abrahao; GADELHA, Ary; CROSSLEY, Nicolas; VIEIRA, Gilson; ZUGMAN, Andre; PICON, Felipe Almeida; PAN, Pedro Mario; HOEXTER, Marcelo Queiroz; JR, Edson Amaro; ANES, Mauricio; MOURA, Luciana Monteiro; DEL'AQUILLA, Marco Antonio Gomes; MCGUIRE, Philip; ROHDEZ, Luis Augusto; MIGUEL, Euripedes Constantino; BRESSAN, Rodrigo Affonseca; JACKOWSKI, Andrea ParolinThe family environment in childhood has a strong effect on mental health outcomes throughout life. This effect is thought to depend at least in part on modifications of neurodevelopment trajectories. In this exploratory study, we sought to investigate whether a feasible resting-state fMRI metric of local spontaneous oscillatory neural activity, the fractional amplitude of low-frequency fluctuations (fALFF), is associated with the levels of children's family coherence and conflict. Moreover, we sought to further explore whether spontaneous activity in the brain areas influenced by family environment would also be associated with a mental health outcome, namely the incidence of behavioral and emotional problems. Resting-state fMRI data from 655 children and adolescents (6-15years old) were examined. The quality of the family environment was found to be positively correlated with fALFF in the left temporal pole and negatively correlated with fALFF in the right orbitofrontal cortex. Remarkably, increased fALFF in the temporal pole was associated with a lower incidence of behavioral and emotional problems, whereas increased fALFF in the orbitofrontal cortex was correlated with a higher incidence.
- Ventral Striatum Functional Connectivity as a Predictor of Adolescent Depressive Disorder in a Longitudinal Community-Based Sample(2017) PAN, Pedro Mario; SATO, Joao R.; SALUM, Giovanni A.; ROHDE, Luis A.; GADELHA, Ary; ZUGMAN, Andre; MARI, Jair; JACKOWSKI, Andrea; PICON, Felipe; MIGUEL, Euripedes C.; PINE, Daniel S.; LEIBENLUFT, Ellen; BRESSAN, Rodrigo A.; STRINGARIS, ArgyrisObjective: Previous studies have implicated aberrant reward processing in the pathogenesis of adolescent depression. However, no study has used functional connectivity within a distributed reward network, assessed using resting-state functional MRI (fMRI), to predict the onset of depression in adolescents. This study used reward network-based functional connectivity at baseline to predict depressive disorder at follow-up in a community sample of adolescents. Method: A total of 637 children 6-12 years old underwent resting-state fMRI. Discovery and replication analyses tested intrinsic functional connectivity (iFC) among nodes of a putative reward network. Logistic regression tested whether striatal node strength, a measure of reward-related iFC, predicted onset of a depressive disorder at 3-year follow-up. Further analyses investigated the specificity of this prediction. Results: Increased left ventral striatum node strength predicted increased risk for future depressive disorder (odds ratio=1.54, 95% CI=1.09-2.18), even after excluding participants who had depressive disorders at baseline (odds ratio=1.52, 95% CI=1.05-2.20). Among 11 reward-network nodes, only the left ventral striatum significantly predicted depression. Striatal node strength did not predict other common adolescent psychopathology, such as anxiety, attention deficit hyperactivity disorder, and substance use. Conclusions: Aberrant ventral striatum functional connectivity specifically predicts future risk for depressive disorder. This finding further emphasizes the need to understand how brain reward networks contribute to youth depression.
- Multicenter Voxel-Based Morphometry Mega-Analysis of Structural Brain Scans in Obsessive-Compulsive Disorder(2014) WIT, Stella J. de; ALONSO, Pino; SCHWEREN, Lizanne; MATAIX-COLS, David; LOCHNER, Christine; MENCHON, Jose M.; STEIN, Dan J.; FOUCHE, Jean-Paul; SORIANO-MAS, Caries; SATO, Joao R.; HOEXTER, Marcelo Q.; DENYS, Damiaan; NAKAMAE, Takashi; NISHIDA, Seiji; KWON, Jun Soo; JANG, Joon Hwan; BUSATTO, Geraldo F.; CARDONER, Narcis; CATH, Danielle C.; FUKUI, Kenji; JUNG, Wi Hoon; KIM, Sung Nyun; MIGUEL, Euripides C.; NARUMOTO, Jin; PHILLIPS, Mary L.; PUJOL, Jesus; REMIJNSE, Peter L.; SAKAI, Yuki; SHIN, Na Young; YAMADA, Kei; VELTMAN, Dick J.; HEUVEL, Odile A. van denObjective: Results from structural neuroimaging studies of obsessive-compulsive disorder (OCD) have been only partially consistent. The authors sought to assess regional gray and white matter volume differences between large samples of OCD patients and healthy comparison subjects and their relation with demographic and clinical variables. Method: A multicenter voxel-based morphometry mega-analysis was performed on 1.5-T str.uctural T-1-weighted MRI scans derived from the International OCD Brain Imaging Consortium. Regional gray and white matter brain volumes were compared between 412 adult OCD patients and 368 healthy subjects. Results: Relative to healthy comparison subjects, OCD patients had significantly smaller volumes of frontal gray and white matter bilaterally, including the dorsomedial prefrontal cortex, the anterior cingulate cortex, and the inferior frontal gyrus extending to the anterior insula. Patients also showed greater cerebellar gray matter volume bilaterally compared with healthy subjects. Group differences in frontal gray and white matter volume were significant after correction for multiple comparisons. Additionally, group-by-age interactions were observed in the putamen, insula, and orbitofrontal cortex (indicating relative preservation of volume in patients compared with healthy subjects with increasing age) and in the temporal cortex bilaterally (indicating a relative loss of volume in patients compared. with healthy subjects with increasing age). Conclusions: These findings partially support the prevailing fronto-striatal models of OCD and offer additional insights into the neuroanatomy of the disorder that were not apparent from previous smaller studies. The group-by-age interaction effects. in orbitofrontal-striatal and (para)limbic brain regions may be the result of altered neuroplasticity associated with chronic compulsive behaviors, anxiety, or compensatory processes related to cognitive dysfunction.
- White matter microstructure and its relation to clinical features of obsessive-compulsive disorder: findings from the ENIGMA OCD Working Group(2021) PIRAS, Fabrizio; PIRAS, Federica; ABE, Yoshinari; AGARWAL, Sri Mahavir; ANTICEVIC, Alan; AMEIS, Stephanie; ARNOLD, Paul; BANAJ, Nerisa; BARGALLO, Nuria; BATISTUZZO, Marcelo C.; BENEDETTI, Francesco; BEUCKE, Jan-Carl; BOEDHOE, Premika S. W.; BOLLETTINI, Irene; BREM, Silvia; CALVO, Anna; CHO, Kang Ik Kevin; CIULLO, Valentina; DALLASPEZIA, Sara; DICKIE, Erin; ELY, Benjamin Adam; FAN, Siyan; FOUCHE, Jean-Paul; GRUNER, Patricia; GUERSEL, Deniz A.; HAUSER, Tobias; HIRANO, Yoshiyuki; HOEXTER, Marcelo Q.; IORIO, Mariangela; JAMES, Anthony; REDDY, Y. C. Janardhan; KAUFMANN, Christian; KOCH, Kathrin; KOCHUNOV, Peter; KWON, Jun Soo; LAZARO, Luisa; LOCHNER, Christine; MARSH, Rachel; NAKAGAWA, Akiko; NAKAMAE, Takashi; NARAYANASWAMY, Janardhanan C.; SAKAI, Yuki; SHIMIZU, Eiji; SIMON, Daniela; SIMPSON, Helen Blair; SORENI, Noam; STAEMPFLI, Philipp; STERN, Emily R.; SZESZKO, Philip; TAKAHASHI, Jumpei; VENKATASUBRAMANIAN, Ganesan; WANG, Zhen; YUN, Je-Yeon; STEIN, Dan J.; JAHANSHAD, Neda; THOMPSON, Paul M.; HEUVEL, Odile A. van den; SPALLETTA, Gianfranco; ASSOGNA, Francesca; CALVO, Rosa; WIT, Stella J. de; HOUGH, Morgan; KUNO, Masaru; MIGUEL, Euripedes C.; MORER, Astrid; PITTENGER, Christopher; POLETTI, Sara; SMERALDI, Enrico; SATO, Joao R.; TSUCHIYAGAITO, Aki; WALITZA, Susanne; WERF, Ysbrand D. van der; VECCHIO, Daniela; ZAREI, MojtabaMicrostructural alterations in cortico-subcortical connections are thought to be present in obsessive-compulsive disorder (OCD). However, prior studies have yielded inconsistent findings, perhaps because small sample sizes provided insufficient power to detect subtle abnormalities. Here we investigated microstructural white matter alterations and their relation to clinical features in the largest dataset of adult and pediatric OCD to date. We analyzed diffusion tensor imaging metrics from 700 adult patients and 645 adult controls, as well as 174 pediatric patients and 144 pediatric controls across 19 sites participating in the ENIGMA OCD Working Group, in a cross-sectional case-control magnetic resonance study. We extracted measures of fractional anisotropy (FA) as main outcome, and mean diffusivity, radial diffusivity, and axial diffusivity as secondary outcomes for 25 white matter regions. We meta-analyzed patient-control group differences (Cohen's d) across sites, after adjusting for age and sex, and investigated associations with clinical characteristics. Adult OCD patients showed significant FA reduction in the sagittal stratum (d=-0.21, z=-3.21, p=0.001) and posterior thalamic radiation (d=-0.26, z=-4.57, p<0.0001). In the sagittal stratum, lower FA was associated with a younger age of onset (z=2.71, p=0.006), longer duration of illness (z=-2.086, p=0.036), and a higher percentage of medicated patients in the cohorts studied (z=-1.98, p=0.047). No significant association with symptom severity was found. Pediatric OCD patients did not show any detectable microstructural abnormalities compared to controls. Our findings of microstructural alterations in projection and association fibers to posterior brain regions in OCD are consistent with models emphasizing deficits in connectivity as an important feature of this disorder.
- High risk cohort study for psychiatric disorders in childhood: rationale, design, methods and preliminary results(2015) SALUM, Giovanni Abrahao; GADELHA, Ary; PAN, Pedro Mario; MORIYAMA, Tais Silveira; GRAEFF-MARTINS, Ana Soledade; TAMANAHA, Ana Carina; ALVARENGA, Pedro; KRIEGER, Fernanda Valle; FLEITLICH-BILYK, Bacy; JACKOWSKI, Andrea; SATO, Joao Ricardo; BRIETZKE, Elisa; POLANCZYK, Guilherme Vanoni; BRENTANI, Helena; MARI, Jair de Jesus; ROSARIO, Maria Conceicao Do; MANFRO, Gisele Gus; BRESSAN, Rodrigo Affonseca; MERCADANTE, Marcos Tomanik; MIGUEL, Euripedes Constantino; ROHDE, Luis AugustoThe objective of this study is to present the rationale, methods, design and preliminary results from the High Risk Cohort Study for the Development of Childhood Psychiatric Disorders. We describe the sample selection and the components of each phases of the study, its instruments, tasks and procedures. Preliminary results are limited to the baseline phase and encompass: (i) the efficacy of the oversampling procedure used to increase the frequency of both child and family psychopathology; (ii) interrater reliability and (iii) the role of differential participation rate. A total of 9937 children from 57 schools participated in the screening procedures. From those 2512 (random =958; high risk =1554) were further evaluated with diagnostic instruments. The prevalence of any child mental disorder in the random strata and high-risk strata was 19.9% and 29.7%. The oversampling procedure was successful in selecting a sample with higher family rates of any mental disorders according to diagnostic instruments. Interrater reliability (kappa) for the main diagnostic instrument range from 0.72 (hyperkinetic disorders) to 0.84 (emotional disorders). The screening instrument was successful in selecting a sub-sample with high risk for developing mental disorders. This study may help advance the field of child psychiatry and ultimately provide useful clinical information.
- Association between abnormal brain functional connectivity in children and psychopathology: A study based on graph theory and machine learning(2018) SATO, Joao Ricardo; BIAZOLI JR., Claudinei Eduardo; SALUM, Giovanni Abrahao; GADELHA, Ary; CROSSLEY, Nicolas; VIEIRA, Gilson; ZUGMAN, Andre; PICON, Felipe Almeida; PAN, Pedro Mario; HOEXTER, Marcelo Queiroz; AMARO JR., Edson; ANES, Mauricio; MOURA, Luciana Monteiro; DEL'AQUILLA, Marco Antonio Gomes; MCGUIRE, Philip; ROHDE, Luis Augusto; MIGUEL, Euripedes Constantino; JACKOWSKI, Andrea Parolin; BRESSAN, Rodrigo AffonsecaObjectives: One of the major challenges facing psychiatry is how to incorporate biological measures in the classification of mental health disorders. Many of these disorders affect brain development and its connectivity.In this study, we propose a novel method for assessing brain networks based on the combination of a graph theory measure (eigenvector centrality) and a one-class support vector machine (OC-SVM).Methods: We applied this approach to resting-state fMRI data from 622 children and adolescents. Eigenvector centrality (EVC) of nodes from positive- and negative-task networks were extracted from each subject and used as input to an OC-SVM to label individual brain networks as typical or atypical. We hypothesised that classification of these subjects regarding the pattern of brain connectivity would predict the level of psychopathology.Results: Subjects with atypical brain network organisation had higher levels of psychopathology (p<0.001). There was a greater EVC in the typical group at the bilateral posterior cingulate and bilateral posterior temporal cortices; and significant decreases in EVC at left temporal pole.Conclusions: The combination of graph theory methods and an OC-SVM is a promising method to characterise neurodevelopment, and may be useful to understand the deviations leading to mental disorders.
conferenceObject Orbitofrontal Thickness as a Measure for Treatment Response Classification in Obsessive-Compulsive Disorder(2014) HOEXTER, Marcelo; DINIZ, Juliana; LOPES, Antonio; BATISTUZZO, Marcelo; SHAVITT, Roseli; DOUGHERTY, Darin; DURAN, Fabio; BRESSAN, Rodrigo; BUSATTO, Geraldo; MIGUEL, Euripedes; SATO, Joao