DANIELA CARLA DE SOUZA
Projetos de Pesquisa
Unidades Organizacionais
PAINT-62, Hospital Universitário
6 resultados
Resultados de Busca
Agora exibindo 1 - 6 de 6
- Latin American Consensus on the Management of Sepsis in Children: Sociedad Latinoamericana de Cuidados Intensivos Pediatricos [Latin American Pediatric Intensive Care Society] (SLACIP) Task Force: Executive Summary(2022) FERNANDEZ-SARMIENTO, Jaime; SOUZA, Daniela Carla De; MARTINEZ, Anacaona; NIETO, Victor; LOPEZ-HERCE, Jesus; LANZIOTTI, Vanessa Soares; LOPEZ, Maria del Pilar Arias; CARVALHO, Werther Brunow De; OLIVEIRA, Claudio F.; JARAMILLO-BUSTAMANTE, Juan Camilo; DIAZ, Franco; YOCK-CORRALES, Adriana; RUVINSKY, Silvina; MUNAICO, Manuel; PAVLICICH, Viviana; IRAMAIN, Ricardo; MARQUEZ, Marta Patricia; GONZALEZ, Gustavo; YUNGE, Mauricio; TONIAL, Cristian; CRUCES, Pablo; PALACIO, Gladys; GRELA, Carolina; SLOCKER-BARRIO, Maria; CAMPOS-MINO, Santiago; GONZALEZ-DAMBRAUSKAS, Sebastian; SANCHEZ-PINTO, Nelson L.; GARCIA, Pedro Celiny; JABORNISKY, Roberto
- Pesquisa em sepse pediátrica em países de baixa e média renda: superando desafios(2021) SOUZA, Daniela Carla de; OLIVEIRA, Cláudio Flauzino de; LANZIOTTI, Vanessa Soares
- The epidemiology of sepsis in paediatric intensive care units in Brazil (the Sepsis PREvalence Assessment Database in Pediatric population, SPREAD PED): an observational study(2021) SOUZA, Daniela Carla de; MARTIN, Joelma Goncalves; LANZIOTTI, Vanessa Soares; OLIVEIRA, Claudio Flauzino de; TONIAL, Cristian; CARVALHO, Werther Brunow de; FIORETTO, Jose Roberto; PIVA, Jefferson Pedro; TROSTER, Eduardo Juan; BOSSA, Aline Siqueira; GREGORINI, Flavia; FERREIRA, Josiane; LUBARINO, Juliana; CAVALCANTI, Alexandre Biasi; MACHADO, Flavia RibeiroBackground Data on the prevalence and mortality of paediatric sepsis in resource-poor settings are scarce. We aimed to assess the prevalence and in-hospital mortality of severe sepsis and septic shock treated in paediatric intensive care units (PICUs) in Brazil, and risk factors for mortality. Methods We performed a nationwide, 1-day, prospective point prevalence study with follow-up of patients with severe sepsis and septic shock, using a stratified random sample of all PICUs in Brazil. Patients were enrolled at each participating PICU on a single day between March 25 and 29, 2019. All patients occupying a bed at the PICU on the study day (either admitted previously or on that day) were included if they were aged 28 days to 18 years and met the criteria for severe sepsis or septic shock at any time during hospitalisation. Patients were followed up until hospital discharge or death, censored at 60 days. Risk factors for mortality were assessed using a Poisson regression model. We used prevalence to generate national estimates. Findings Of 241 PICUs invited to participate, 144 PICUs (capacity of 1242 beds) included patients in the study. On the day of the study, 1122 children were admitted to the participating PICUs, of whom 280 met the criteria for severe sepsis or septic shock during hospitalisation, resulting in a prevalence of 25.0% (95% CI 21.6-28.8), with a mortality rate of 19.8% (15.4-25.2; 50 of 252 patients with complete clinical data). Increased risk of mortality was associated with higher Pediatric Sequential Organ Failure Assessment score (relative risk per point increase 1.21, 95% CI 1.14-1.29, p<0.0001), unknown vaccination status (2.57, 1.26-5.24; p=0.011), incomplete vaccination status (2.16, 1.19-3.92; p=0.012), health care-associated infection (2.12, 1.23-3.64, p=0.0073), and compliance with antibiotics (2.38, 1.46-3.86, p=0.0007). The estimated incidence of PICU-treated sepsis was 74.6 cases per 100 000 paedi-atric population (95% CI 61.5-90.5), which translates to 42 374 cases per year (34 940-51 443) in Brazil, with an estimated mortality of 8305 (6848-10 083). Interpretation In this representative sample of PICUs in a middle-income country, the prevalences of severe sepsis or septic shock and in-hospital mortality were high. Modifiable factors, such as incomplete vaccination and health care-associated infections, were associated with greater risk of in-hospital mortality.
- Pediatric Sepsis Worldwide: Understand to Improve Outcomes(2020) SOUZA, Daniela Carla de; LANZIOTTI, Vanessa Soares
- COVID-19 PICU guidelines: for high- and limited-resource settings(2020) KACHE, Saraswati; CHISTI, Mohammod Jobayer; GUMBO, Felicity; MUPERE, Ezekiel; ZHI, Xia; NALLASAMY, Karthi; NAKAGAWA, Satoshi; LEE, Jan Hau; NARDO, Matteo Di; OLIVA, Pedro de la; KATYAL, Chhavi; ANAND, Kanwaljeet J. S.; SOUZA, Daniela Carla de; LANZIOTTI, Vanessa Soares; CARCILLO, JosephBackground Fewer children than adults have been affected by the COVID-19 pandemic, and the clinical manifestations are distinct from those of adults. Some children particularly those with acute or chronic co-morbidities are likely to develop critical illness. Recently, a multisystem inflammatory syndrome (MIS-C) has been described in children with some of these patients requiring care in the pediatric ICU. Methods An international collaboration was formed to review the available evidence and develop evidence-based guidelines for the care of critically ill children with SARS-CoV-2 infection. Where the evidence was lacking, those gaps were replaced with consensus-based guidelines. Results This process has generated 44 recommendations related to pediatric COVID-19 patients presenting with respiratory distress or failure, sepsis or septic shock, cardiopulmonary arrest, MIS-C, those requiring adjuvant therapies, or ECMO. Evidence to explain the milder disease patterns in children and the potential to use repurposed anti-viral drugs, anti-inflammatory or anti-thrombotic therapies are also described. Conclusion Brief summaries of pediatric SARS-CoV-2 infection in different regions of the world are included since few registries are capturing this data globally. These guidelines seek to harmonize the standards and strategies for intensive care that critically ill children with COVID-19 receive across the world. Impact At the time of publication, this is the latest evidence for managing critically ill children infected with SARS-CoV-2. Referring to these guidelines can decrease the morbidity and potentially the mortality of children effected by COVID-19 and its sequalae. These guidelines can be adapted to both high- and limited-resource settings.
- Coronavirus Disease 2019: Understanding Immunopathogenesis Is the ""Holy Grail"" to Explain Why Children Have Less Severe Acute Disease(2020) LANZIOTTI, Vanessa Soares; SOUZA, Daniela Carla de; MARQUES, Ernesto T. A.