FABIO GUILHERME CASERTA MARYSSAEL DE CAMPOS
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
4 resultados
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Agora exibindo 1 - 4 de 4
- CAN SUCRALFATE ENMA PREVENT COLTIS IN COLONIC SEGMENTS WITHOUT FCL TRNSIT?(2021) MENDONCA, Roberta Lais Silva; KANNO, Danilo Toshio; PEREIRA, Jose Aires; CAMPOS, Fabio Guilherme; SILVA, Camila Morais Goncalves da; FREITAS, Bruna Zini de Paula; MARTINEZ, Carlos Augusto RealBACKGROUND: Oxidative stress is one of the main mechanisms associated with the rupture of the defense mechanisms of the colonic epithelial barrier; it reduces the tissue content of the claudin-3 and occludin proteins, which are the main constituents of intercellular tight junctions. Sucralfate (SCF) has antioxidant activity and has been used to treat different forms of colitis. AIM: This study aimed to measure the tissue claudin-3 and occludin content of the colon mucosa without fecal transit, subjected to intervention with SCF. METHODS:Thirty-six rats were subjected to left colon colostomy and distal mucous fistula. They were divided into two groups according to euthanasia that was performed 2 or 4 weeks after the intervention. Each group was divided into three subgroups according to the enema applied daily: saline alone, SCF at 1 g/kg/day, or SCF at 2 g/kg/day. Colitis was diagnosed by the histological analysis adopting the previous validate scale. The tissue expression of both proteins was identified by immunohistochemical technique. The content of proteins was quantified by computer-assisted image analysis. RESULTS:The inflammatory score was high in colonic segments without fecal transit, and enemas with SCF reduced the inflammatory score in these segments, mainly in those animals submitted to intervention with SCF in greater concentration and for a longer period of intervention. There was an increase in tissue content of claudin-3 and occludin, related to SCF concentration. The tissue content of both proteins was not related to the intervention time. CONCLUSION:Enemas with SCF reduced the inflammation and increased the tissue content of claudin-3 and occludin in colonic mucosa without fecal stream.
- LAPAROSCOPIC SPLENIC FLEXURE MOBILIZATION: TECHNICAL ASPECTS, INDICATION CRITERIA AND OUTCOMES(2021) CAMPOS, Fabio Guilherme; BUSTAMANTE-LOPEZ, Leonardo Alfonso; MARTINEZ, Carlos Augusto
- PANCREATIC SOLID-PSEUDOPAPILLARY NEOPLASM IN PATIENTS WITH FAMILIAL ADENOMATOUS POLYPOSIS(2022) MEIRA-JUNIOR, Jose Donizeti; YOGOLARE, GustavoGonclaves; MAGALHAES, Daniel de Paiya; NAMUR, Guilherme Naccache; CAMPOS, Fabio Guilherme; SEGATELLI, Vanderlei; NAHAS, Sergio Carlos; JUKEMURA, JoseBACKGROUND:Solid pseudopapillary neoplasm of the pancreas is an uncommon pancreatic tumor, which is more frequent in young adult women. Familial adenomatous polyposis is a genetic condition associated with colorectal cancer that also increases the risk of developing other tumors as well.AIM:The aim of this study was to discuss the association of familial adenomatous polyposis with solid pseudopapillary neoplasm of the pancreas, which is very rare.METHODS:We report two cases of patients with familial adenomatous polyposis who developed solid pseudopapillary neoplasm of the pancreas of the pancreas and were submitted to laparoscopic pancreatic resections with splenic preservation (one male and one female).RESULTS:ß-catenin and Wnt signaling pathways have been found to play an important role in the tumorigenesis of solid pseudopapillary neoplasm of the pancreas, and their constitutive activation due to adenomatous polyposis coli gene inactivation in familial adenomatous polyposis may explain the relationship between familial adenomatous polyposis and solid pseudopapillary neoplasm of the pancreas.CONCLUSION:Colonic resection must be prioritized, and a minimally invasive approach is preferred to minimize the risk of developing desmoid tumor. Pancreatic resection usually does not require extensive lymphadenectomy for solid pseudopapillary neoplasm of the pancreas, and splenic preservation is feasible.
- IS IT POSSIBLE TO OPTIMIZE STAPLED HEMORRHOIDOPEXY OUTCOMES BY ENLARGING OPERATIVE CRITERIA INDICATIONS? RESULTS OF A TAILORED PROCEDURE WITH ASSOCIATED RESECTION IN A COMPARATIVE PERSONAL SERIES(2022) CAMPOS, Fabio Guilhermel; CAVALARI-MANCUZO, Daiane; BUSTAMANTE-LOPEZ, Leonardo Alfonso; MORAIS, Paula Gabriela Melo; MARTINEZ, Carlos Augusto RealBACKGROUND: Since its introduction, stapled hemorrhoidopexy has been increasingly esplenectomia (DAPE) associada a terapia endoscopica. Porem, estudos mostram aumento do indicatedcalibre in dasthe varizes managentem algunsof hemorrhoidalpacientes durantdisease. oAIM:Ourseguimento primary em endlong point prazo.was to Objetivo: evaluate Avalar o impacto da DAPE e tratameto endoscopo pos-operatorio no comportmento the incidence of recurrent disease requiring another surgical intervention. On a secondary analysis, we das varizes esofagicas e recidiva hemorragica, de pacientes esquistossomoticos. Metodos: also compared pain, complications, and patient's satisfaction after a tailored surgery. METHODS: We retrospectively reviewed 196 patients (103 males and 93 females) wth a median age of 47.9 years Foram estudados 36 pacientes com seguimento superior a cinco anos, distribuidos em (range, 17-78) who were undergoing stapled hemorrhoidopexy alone (STG; n=65) or combined dois grupos: queda da ressao portal abaixo de 30% e acima de 30% comparados com o surgery (CSG; n=131, stapled hemorrhoidopexy associated with resection). RESULTS: Complications werecalibre dasdetected varizes in 11 (5.6%)esofagicas nopatients (4.6%pos-operatorio for STG vs. precoce6.1% e for tardioCSG; alem p=0.95).do Atindice the de same recidvatime, heorragica. Resultados symptoms recurrence (13.8% vs. 8.4%; p=034), reoperation rate for complications (3.1% vs. 3.0%; esofagicas que, durante o seguimento aumentaram de calibre e foram controladas com p=1.0), and reoperation rate for recurrence (6.1% vs. 4.6%; p=1.0) were not different among groups. Grade IV patients were more commonly managed with simultaneous stapling and resection (63% vs. 49.5%), but none of them presented symptoms recurrence nor need reoperation due to o comportamento do calibre das varizes no pos-operatorio precoce nem tardio nem os recurrence. Median pain score during the first week was higher in CSG patients (0.8 vs. 1.7). After a indicesfollow-up de of recidiva24.9 months, hemorragca. satisfactin Conclusao scores were similar (8.6; p=0.8). CONCLUSION: Recurrent symptoms were observed in 10% of patients, requiring surgery in approximately half of them. Even operatorios precoces ou tardios. A comparacao entre a queda de pressao do portal e as though the association of techniques may raise pain scores, a tailored approach based on amplified indication criteria and combined techniques seems to be an effective and safe alternative, with decreased relapse rates in patients suffering from more advanced hemorrhoidal disease. Satisfaction DESCRITORES: Esquistossomose mansoni. Hipertensao portal. Cirurgia. Pressao na veia porta. Varizes esofagicas scores after hemorrhoidopexy are high.