EDNA MARIA DE ALBUQUERQUE DINIZ
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Pediatria, Faculdade de Medicina - Docente
Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/36 - Laboratório de Pediatria Clínica, Hospital das Clínicas, Faculdade de Medicina
Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/36 - Laboratório de Pediatria Clínica, Hospital das Clínicas, Faculdade de Medicina
2 resultados
Resultados de Busca
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- Use of budesonide associated with a pulmonary surfactant to prevent bronchopulmonary dysplasia in premature newborns- A systematic review(2023) MORAES, Lucas Hirano Arruda; COELHO, Rachel Mocelin Dias; BEOZZO, Glenda Priscila Neves dos Santos; YOSHIDA, Renata de Araujo Monteiro; DINIZ, Edna Maria de Albuquerque; CARVALHO, Werther Brunow deObjective: Among the mechanisms proposed for the development of bronchopulmonary dysplasia is the increase in the pulmonary inflammatory process and oxidative stress. Thus, the control of this process may result in improvements in bronchopulmonary dysplasia-related outcomes. This study aims to analyze the current scientific evidence regarding the use of budesonide, a potent anti-inflammatory drug, associated with a pulmonary surfactant to prevent bronchopulmonary dysplasia.Methods: A systematic review of the literature was performed on the Embase and MEDLINE plat-forms, and studies that compared budesonide with pulmonary surfactant versus pulmonary sur-factant for treating respiratory distress syndrome were included. The primary outcome was a reduction in bronchopulmonary dysplasia or death. Results: Four randomized clinical trials and two observational studies were included in this systematic review. Three of the randomized clinical trials found a reduction in bronchopulmonary dysplasia or death in the use of budesonide with the surfactant, all the other studies (1 clinical trial and 2 observa-tional studies) found no statistical differences between the groups for the primary outcomes. The three main studies showed a reduction in the primary outcome; however, all studies showed great heteroge-neity regarding the type of surfactant (poractant or beractant) and the method of administration. Conclusion: Robust clinical studies, in a heterogeneous population, using porcine surfactant associated with budesonide, with administration by a minimally invasive technique are necessary for there to be a recommendation based on scientific evidence for its widespread use.(c) 2022 Sociedade Brasileira de Pediatria.
conferenceObject METABOLIC ALTERATIONS AND GROWTH DISORDERS IN CHILDREN BORN WITH VERY LOW BIRTH WEIGHT AND PRETERM INFANTS SMALL FOR GESTATIONAL AGE AT 36 MONTHS OF CORRECTED GESTATIONAL AGE(2023) ATHAYDE, D.; COMINATO, L.; ATHAYDE, G.; FIRMINO, S.; SADECK, L.; DINIZ, E.; DAMIANI, D.