LUCIANO FERREIRA DRAGER

(Fonte: Lattes)
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Departamento de Clínica Médica, Faculdade de Medicina - Docente
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/63, Hospital das Clínicas, Faculdade de Medicina - Líder

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Revista / Livro: Sleep Medicine ×

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  • conferenceObject
    AWARENESS FOR OSA DIAGNOSIS IN A TERTIARY CARDIOLOGY CENTER: A TEMPORAL SURVEY
    (2019) FURLAN, S. F.; COSTA, L. E.; SINKUNAS, V.; ALVES, R. S. C.; PINTAO, M. C. T.; CAMPOS, B. A.; LORENZI, G.; DRAGER, L. F.
  • conferenceObject
    TEMPORAL TRENDS IN POLYSOMNOGRAPHY REQUEST BY SPECIALTIES IN A LARGE PRIVATE SERVICE IN BRAZIL: THE IMPORTANCE OF CARDIOLOGY IN OSA DIAGNOSIS
    (2019) FURLAN, S.; CAMPOS, B. A.; PINTAO, M. C. T.; SMANIO, P. E. P.; DRAGER, L. F.; ALVES, R. S. C.
  • conferenceObject
    INTERACTIONS BETWEEN OBSTRUCTIVE SLEEP APNEA AND SLEEP DURATION WITH SUBCLINICAL ATHEROSCLEROSIS EVALUATED BY CORONARY CALCIUM SCORE: CROSS-SECTIONAL DATA FROM ELSA-BRASIL STUDY
    (2019) SOUZA, S. Pereira e; BITTENCOURT, S. M.; PARISE, K. B.; SANTOS, B. R.; SILVA, A. W.; AIELO, N. A.; PADOVESI, G. S.; FILHO, L. G.; BENSENOR, M. I.; LOTUFO, A. P.; DRAGER, F. L.
  • article 1 Citação(ões) na Scopus
    Excessive daytime sleepiness, but not sleep apnea, sleep duration or insomnia, was associated with poor adherence to anti-hypertensive treatment: The ELSA-Brasil study
    (2023) AIELO, Aline N.; SANTOS, Ronaldo B.; GIATTI, Soraya; SILVA, Wagner A.; PARISE, Barbara K.; CUNHA, Lorenna F.; SOUZA, Silvana P.; LOTUFO, Paulo A.; BENSENOR, Isabela M.; DRAGER, Luciano F.
    Hypertension is the leading risk factor for cardiovascular mortality. Poor adherence may partially explain this scenario. Beyond traditional factors, it is conceivable that sleep conditions such as Obstructive Sleep Apnea (OSA), Sleep Duration (SDUR), sleepiness and insomnia may contribute to impair adherence but the evidence is scanty. Consecutive participants with hypertension from the ELSA-Brasil study performed a home sleep monitoring and 7-days actigraphy to determine OSA (apnea-hypopnea index >= 15 events/ hour) and SDUR, respectively. Excessive daytime sleepiness (EDS) and insomnia were evaluated by Epworth Sleepiness Scale (ESS) and Clinical Interview Scheduled Revised (CIS-R), respectively. The 4itens Morisky questionnaire was used to evaluate adherence to anti-hypertensive therapy. A total of 411 patients were including in the analysis (mean age: 54 +/- 8 years, 47% men). Medium/low adherence to anti-hypertensive therapy was observed in 62%. Compared to the high adherence group, the participants with medium/low adherence had lower frequencies of Whites (64.1 vs. 47.8%), high-degree education (50.6 vs. 40%), and monthly per-capita income ($1021.90 vs. $805.20). In contrast, we observed higher frequency of EDS (35.9 vs. 46.1%). No differences were observed for OSA, short SDUR (<6 h) and insomnia. Logistic regression analysis showed that race other than White (OR: 1.80; 95% IC:1.15-2.82), lower monthly income (OR: 1.74; 95% IC:1.01-3.0) and EDS (OR: 1.63; 95% IC:1.05-2.53) were independently associated with medium/low adherence to the anti-hypertensive treatment. Interestingly, EDS mediated the abdominal obesity-adherence outcome. In conclusion, among sleep-related parameters, EDS, but not OSA, short SDUR or insomnia, were associated to impaired adherence to anti-hypertensive therapy.(c) 2023 Elsevier B.V. All rights reserved.
  • article 4 Citação(ões) na Scopus
    Obstructive sleep apnea, sleep duration and chronic kidney disease in patients with coronary artery disease
    (2021) FURLAN, Sofia F.; SINKUNAS, Viktor; DAMIANI, Lucas P.; SANTOS, Ronaldo B.; PERES, Matheus; LEMOS, Pedro A.; LEE, Chi-Hang; LORENZI-FILHO, Geraldo; DRAGER, Luciano F.
    Y Background: Limited evidence is available addressing the potential role of sleep disorders on renal function. Here, we aimed to explore the associations of obstructive sleep apnea (OSA) and sleep duration (SD) with renal function in subjects with high cardiovascular risk. Methods: Consecutive subjects with coronary artery disease (CAD) underwent clinical evaluation, sleep study to define OSA and one-week wrist actigraphy to objectively measure SD. OSA was defined by an apnea-hypopnea index (AHI) of >15 events/hour. The estimated glomerular filtration rate (eGFR) was calculated using the CKD-EPI equation. We analyzed the associations of OSA and SD with continuous eGFR values and according to the presence of CKD (eGFR<60 mL/min/1.73 m(2)) after adjusting for multiple confounding factors. Results: We studied 242 subjects (62.8% men). The frequency of OSA was 55.4% and the median SD was 412.8 (363.4-457.25) min. There was no difference in the eGFRs between participants with and without OSA (69.3 +/- 19.1 vs. 74.6 +/- 19.3 mL/min/1.73 m(2), p = 0.72) and the rate of eGFR <60 mL/min/1.73 m(2) (34.3% vs. 25.9%; p = 0.21). Similarly, we did not find differences in patients in eGFR for those with SD > 6 h versus SD < 6 h (72.5 +/- 20.3 vs. 71.4 +/- 19.1 mL/min/1.73 m(2), p = 0.72). In the linear regression analysis, AHI was independently associated with an eGFR<60 mL/min/1.73 m(2) in the unadjusted model [-0.15 (-0.27 to-0.04)], (P = 0.01), but not in the adjusted models. Analyses of continuous SD or the stratification in SD >= 6 h or <6 h also revealed neutral results on eGFR. Conclusion: OSA severity and SD were not independently associated with CKD in subjects with CAD.
  • conferenceObject
    LONG-TERM EFFECTS OF BARIATRIC SURGERY ON OBSTRUCTIVE SLEEP APNEA IN PATIENTS WITH GRADE 1 AND GRADE 2 OBESITY: A SUB ANALYSIS FROM GATEWAY STUDY
    (2019) FURLAN, S. Fontanello; DRAGER, L. Ferreira; MARTINS, F. Chies; SANTUCCI, E. Vieira; SANTOS, R. Nakagawa; DAMIANI, L. Petri; LORENZI-FILHO, G.; CAVALCANTI, A. Biasi; SCHIAVON, C. A.
  • article 6 Citação(ões) na Scopus
    Accuracy of global and/or regional anthropometric measurements of adiposity in screening sleep apnea: the ELSA-Brasil cohort
    (2019) SANTOS, Ronaldo B.; SILVA, Wagner A.; PARISE, Barbara K.; GIATTI, Soraya; AIELO, Aline N.; SOUZA, Silvana P.; SANTOS, Itamar S.; LOTUFO, Paulo A.; BENSENOR, Isabela M.; DRAGER, Luciano F.
    Objective: Adiposity is a well-established risk factor for obstructive sleep apnea (OSA) but the existence of a preferable anthropometric measurement is not established or whether the combination of measurements may improve the accuracy to detect OSA. This study aimed to compare the accuracies of body mass index (BMI), several surrogate markers of body fat (in isolation or combined) and validated questionnaires for screening OSA. Methods: A total of 2059 participants from the ELSA-Brasil study given anthropometric measurements using standard procedures and a home sleep study. OSA was defined by an apnea-hypopnea index >= 15 events/hour. Results: The frequency of OSA was 32.3%. Compared with the non-OSA group, all anthropometric measurements were higher in the OSA group. Age and gender-adjusted BMI afforded the highest accuracy to detect OSA [AUC = 0.760 (0.739-0.781)], followed by waist [AUC = 0.753 (0.732-0.775)] and neck [AUC = 0.733 (0.711-0.755)] circumferences, waist-to-hip ratio [AUC = 0.722 (0.699-0.745)] and body shape index [AUC = 0.680 (0.656-0.704)]. The combination of two or more anthropometric measurements did not improve the accuracy of BMI in predicting OSA. The adjusted BMI had similar predictive performance to the NoSAS score [AUC = 0.748 (0.727-0.770)] but a better accuracy than the Berlin Questionnaire [AUC = 0.676 (0.653-0.699)]. Conclusions: Despite one's intuition, surrogate markers of regional adiposity are not better than BMI in screening OSA. Combining measurements of global and/or regional adiposity did not have additional value in detecting OSA. The merely fair accuracy range of BMI and sleep questionnaires underscore the need for additional tools to improve OSA underdiagnosis.
  • conferenceObject
    THE IMPACT OF OBSTRUCTIVE SLEEP APNEA ON CHRONIC KIDNEY DISEASE INCIDENCE AFTER ACUTE CARDIOGENIC PULMONARY EDEMA: A SUB-ANALYSIS OF OSA-CARE STUDY
    (2019) FURLAN, S. Fontanello; MACEDO, T. Andrade de; GIOVANINI, G.; OLIVEIRA JUNIOR, M. Tavares de; BORTOLLOTO, L. A.; LORENZI-FILHO, G.; DRAGER, L. Ferreira
  • conferenceObject
    OBSTRUCTIVE SLEEP APNEA IS ASSOCIATED WITH HIGHER LEFT VENTRICLE HYPERTROPHY FREQUENCY IN PATIENTS WITH RESISTANT HYPERTENSION
    (2019) CABRINI, M. L.; MACEDO, T. A.; BARROS, S. de; AZAM, I. F. B.; PIO-ABREU, A.; SILVA, G. V.; LORENZI-FILHO, G.; BORTOLOTTO, L. A.; DRAGER, L. F.
  • conferenceObject
    ASSOCIATION OF SALT INTAKE WITH OBSTRUCTIVE SLEEP APNEA: DATA FROM THE ELSA-BRASIL COHORT
    (2019) GIATTI, S.; SANTOS, R. Batista dos; AIELO, A. Nogueira; SILVA, W. Alves da; PARISE, B.; PIO-ABREU, A.; SOUSA, S.; BORTOLOTTO, L.; LOTUFO, P.; BENSENOR, I.; DRAGER, L. Ferreira