RENATO MADRID BALDASSARE

(Fonte: Lattes)
Índice h a partir de 2011
2
Lattes
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Instituto Central, Hospital das Clínicas, Faculdade de Medicina

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  • article 31 Citação(ões) na Scopus
    Pegylated interferon alfa for chronic hepatitis B: systematic review and meta-analysis
    (2016) KIM, V.; ABREU, R. M.; NAKAGAWA, D. M.; BALDASSARE, R. M.; CARRILHO, F. J.; ONO, S. K.
    Conventional interferon alfa and nucleos(t)ide analogues, such as lamivudine, are frequently used for chronic hepatitis B (CHB) treatment, but are associated with adverse effects and viral resistance. Here we performed a systematic review and meta-analysis evaluating all studies of pegylated interferon alfa (PEG-IFN) treatment in hepatitis B e antigen (HBeAg)-positive and HBeAg-negative patients with CHB. We searched electronic databases - PubMed, EMBASE, Cochrane Library and LILACS - for randomized controlled trials evaluating PEG-IFN therapy between 1999 and September 2014. Virological response was the primary outcome. We identified 14 studies involving 2829 patients. Our analysis revealed that PEG-IFN+lamivudine combination therapy produced better virological and biochemical responses than PEG-IFN monotherapy in HBeAg-positive and HBeAg-negative patients at the end of treatment. PEG-IFN+adefovir dipivoxil achieved better seroconversion rate than PEG-IFN in HBeAg-positive patients at the end of treatment. The present findings demonstrated a beneficial response rate following PEG-IFN combination therapy with nucelos(t)ides among HBeAg-positive and HBeAg-negative patients with CHB. Further trials are needed to investigate simultaneous and sequential therapy strategies.
  • article 12 Citação(ões) na Scopus
    Overcoming barriers to providing comprehensive inpatient care during the COVID-19 pandemic
    (2020) MIETHKE-MORAIS, Anna; PERONDI, Beatriz; HARIMA, Leila; MONTAL, Amanda C.; BALDASSARE, Renato Madrid; MORAES, Danielle P.; PEDROSO, Lucila; RAMOS, Marcelo C. A.; FUSCO, Solange R. G.; PEREIRA, Antonio Jose; BARROS-FILHO, Tarci Prime Sio E. P.; BONFA, Eloisa; UTIYAMA, Edivaldo M.; SEGURADO, Aluisio C.