LUIZ EUGENIO GARCEZ LEME
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Ortopediae Traumatologia, Faculdade de Medicina - Docente
LIM/41 - Laboratório de Investigação Médica do Sistema Músculoesquelético, Hospital das Clínicas, Faculdade de Medicina
LIM/41 - Laboratório de Investigação Médica do Sistema Músculoesquelético, Hospital das Clínicas, Faculdade de Medicina
36 resultados
Resultados de Busca
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- Moderate levels of physical fitness maintain telomere length in non-senescent T CD8(+) cells of aged men(2020) BASTOS, Marta Ferreira; MATIAS, Manuella de Sousa Toledo; ALONSO, Angelica Castilho; SILVA, Leia Cristina Rodrigues; ARAUJO, Adriana Ladeira de; SILVA, Paulo Roberto; BENARD, Gil; BOCALINI, Danilo Sales; BAKER, Julien Steven; LEME, Luiz Eugenio GarcezOBJECTIVES: Immunosenescence is an age-associated change characterized by a decreased immune response. Although physical activity has been described as fundamental for maintaining the quality of life, few studies have evaluated the effects of different levels of exercise on telomere length in aged populations. The present study aimed to analyze the effects of different levels of physical activity, classified by the Maximal oxygen consumption (VO2 max) values, on the telomere length of memory Cluster of differentiation (CD) CD4(+) (CD45RO(neg) and CD45RO(+) ), effector CD8(+)CD28(neg), and CD8(+) CD28(+) T cells in aged individuals. METHODS: Fifty-three healthy elderly men (aged 65-85 years) were included in this study. Their fitness level was classified according to the American College of Sports Medicine (ACSM) for VO2 max (mL/kg/min). Blood samples were obtained from all participants to analyze the percentage of CD3, CD4, CD8, CD28(+), naive, and subpopulations of memory T cells by using flow cytometry. Furthermore, using the Flow-FISH methodology, the CD4(+) CD45RO(+), CD4(+) CD45RO(neg), CD8(+) CD28(+), and CD8(+) CD28(neg)T cell telomere lengths were measured. RESULTS: There was a greater proportion of effector memory T CD4(+) cells and longer telomeres in CD8(+) CD28(+) T cells in the moderate physical fitness group than in the other groups. There was a higher proportion of terminally differentiated memory effector T cells in the low physical fitness group. CONCLUSION: A moderate physical activity may positively influence the telomere shortening of CD28(+) CD8(+)1 cells. However, additional studies are necessary to evaluate the importance of this finding with regard to immune function responses in older men.
- PREVALENCE OF ACUTE DISEASES IN THE ELDERLY ASSISTED IN EMERGENCY DEPARTMENT OF ORTHOPEDICS(2014) DOTTA, Thiago de Angelis Guerra; BONADIO, Marcelo Batista; FURLANETO, Maria Elisabet; SILVA, Jorge dos Santos; LEME, Luiz Eugenio GarcezObjective: To make an analysis of the care of elderly in an Emergency Department of Orthopedics with the primary objective to know the percentage of elderly treated, their conditions of origin and level of accidental conditions, and examine possible comorbidities, evolution and mortality rate. Methods: Retrospective observational epidemiological study based on survey records of a tertiary hospital during one year (January to December 2006) Results: In the year 2006 (January to December) 12,916 calls to patients older than 60 were performed. Conclusion: Massive attendance of the elderly population was observed, however, the vast majority related to chronic problems that do not require urgent attention. Patients requiring urgent attention suffer from trauma related to falls and are between the seventh and ninth decades of life, mostly female and requiring hospitalization for longer periods.
article 2 Citação(ões) na Scopus Vaccines for preventing herpes zoster in older adults Comment(2014) LEME, Luiz Eugenio Garcez- RELATIONSHIP OF FORCE PLATFORM WITH THE CLINICAL BALANCE EVALUATION SYSTEMS TEST IN OLDER ADULTS(2020) ERNANDES, Rita De Cassia; BRECH, Guilherme Carlos; LUNA, Natalia Mariana Silva; NUNES, Michele Figueira; GREVE, Julia Maria D'Andrea; LEME, Luiz Eugenio Garcez; ALONSO, Angelica CastilhoThe aging process can alter the organization of postural control causing instability; literature shows several equipment and clinical tests whose purpose is to measure postural balance, involving different protocols and methodologies. Objective: To evaluate postural balance during the task to walk over the force platform (turn and return) and its relationship with clinic balance test (BESTest) in older adults. Methods: 60 older people of both sexes, aged 60 to 79 years, were tested in the force platform (NeuroCom Balance) and BESTest to evaluate postural balance. Results: negative correlations were found when comparing domains of the clinical test with stabilometric parameters in time and velocity variables of the tests Step/Quick turn. The highest correlations were in the total score (time spent to perform the task - 0.41, and in the velocity left side - 0.33/right side - 0.43), as well as in the stability limit (time spent to perform the task left side - 0.34/right side - 0.37, and the equilibrium velocity left side - 0.37/right side - 0.43). Conclusion: There are slim correlations between the clinical test and force platform variables, showing that each test measures different parameters.
- Association between handgrip strength, balance, and knee flexion/extension strength in older adults(2018) ALONSO, Angelica Castilho; RIBEIRO, Samia Maria; LUNA, Natalia Mariana Silva; PETERSON, Mark D.; BOCALINI, Danilo Sales; SERRA, Marcos Mauricio; BRECH, Guilherme Carlos; GREVE, Julia Maria D. Andrea; GARCEZ-LEME, Luiz EugenioThe objective of the study was to examine the association between handgrip strength (HGS), knee flexion and extension strength, and static and dynamic balance in older women. One hundred and ten women with a mean age of 67.4 +/- 5.9 years were assessed for dynamic postural balance using the Time Up & Go Test (TUG) with and without cognitive tasks. Semi-static balance was assessed by means of a force platform; knee flexor and extensor muscle strength was calculated using an isokinetic dynamometer; and HGS using a hand held dynamometer. Weaker HGS was significantly correlated with worse performance in dynamic postural balance, as well as performance with TUG with and without cognitive tasks; however, there was no correlation between HGS and static balance. There was a moderate positive correlation between knee flexion/extension strength and HGS. This suggests that HGS could be used as a proxy indicator of overall strength capacity for clinical screening among older women.
- Predicting delirium after hip fracture with a 2-min cognitive screen: prospective cohort study(2016) FORTES-FILHO, Sileno Queiroz; APOLINARIO, Daniel; MELO, Juliana Araujo; SUZUKI, Itiro; SITTA, Maria Do Carmo; LEME, Luiz Eugenio GarcezBackground: although the importance of identifying hip fracture patients with high risk for delirium has been well established, considerable controversy exists over the choice of the screening tool. The most commonly used cognitive screeners take an excessive amount of time and include drawing tasks that can be troublesome for individuals with hip fracture who are invariably lying in bed. Objective: to evaluate the properties of the 10-point Cognitive Screener (10-CS), a 2-min bedside tool, for predicting delirium in older adults with hip fracture. Design: prospective cohort study. Setting: a tertiary referral hospital in Sao Paulo, Brazil. Subjects: non-delirious older adults with hip fracture (n = 147). Methods: the 10-CS was administered as a baseline predictor. The test is composed of three-item temporal orientation (date, month, year), category fluency (animals in 1 min) and three-word recall. Incident delirium has been diagnosed according to the Confusion Assessment Method (CAM) that was administered daily from admission to discharge. Results: during hospitalisation, 61 (41.5%) patients developed delirium. The 10-CS presented excellent accuracy for predicting delirium, with an area under ROC curve of 0.83 (95% CI 0.76-0.89). After adjusting for demographic and clinical variables, participants with probable cognitive impairment (score <= 5) were more likely to develop delirium (HR = 7.48; 95% CI 2.2-25.4) compared with participants with a normal score. Lower scores on the 10-CS were also independently associated with a longer length of stay. Conclusions: the 10-CS is an easy-to-use bedside tool with adequate properties to stratify the risk of delirium in older adults with hip fracture.
- A 2-Minute Cognitive Screener for Predicting 1-Year Functional Recovery and Survival in Older Adults After Hip Fracture Repair(2022) FORTES-FILHO, Sileno De Queiroz; ALIBERTI, Marlon Juliano Romero; MELO, Juliana de Araujo; APOLINARIO, Daniel; SITTA, Maria do Carmo; SUZUKI, Itiro; GARCEZ-LEME, Luiz EugenioBackground: Implementing cognitive assessment in older people admitted to hospital with hip fracture-lying in bed, experiencing pain-is challenging. We investigated the value of a quick and easy-to-administer 10-point Cognitive Screener (10-CS) in predicting 1-year functional recovery and survival after hip surgery. Methods: Prospective cohort study comprising 304 older patients (mean age = 80.3 +/- 9.1 years; women = 72%) with hip fracture consecutively admitted to a specialized academic medical center that supports secondary hospitals in Sao Paulo Metropolitan Area, Brazil. The 10-CS, a 2-minute bedside tool including temporal orientation, verbal fluency, and three-word recall, classified patients as having normal cognition, possible cognitive impairment, or probable cognitive impairment on admission. Outcomes were time-torecovery activities of daily living (ADLs; Katz index) and mobility (New Mobility Score), and survival during 1-year after hip surgery. Hazard models, considering death as a competing risk, were used to associate the 10-CS categories with outcomes after adjusting for sociodemographic and clinical measures. Results: On admission, 144 (47%) patients had probable cognitive impairment. Compared to those cognitively normal, patients with probable cognitive impairment presented less postsurgical recovery of ADLs (77% vs 40%; adjusted sub-hazard ratio [HR] = 0.44; 95% confidence interval (CI] = 0.32-0.62) and mobility (50% vs 30%; adjusted sub-HR = 0.52; 95% CI = 0.34-0.79), and higher risk of death (15% vs 40%; adjusted HR = 2.08; 95% CI = 1.03-4.20) over 1-year follow-up. Conclusions: The 10-CS is a strong predictor of functional recovery and survival after hip fracture repair. Cognitive assessment using quick and easy-to-administer screening tools like 10-CS can help clinicians make better decisions and offer tailored care for older patients admitted with hip fracture.
conferenceObject Cardiorespiratory Responses During Graded Exercise Test In Elderly Male Runners According To Training Volume(2012) HIRAO, Leonardo K.; ARAUJO, Ana Carolina C.; PRADO, Danilo M.; PICANCO, Andreia R.; LEME, Luiz E. GarcezbookPart Lombalgia(2012) LEME, Luiz Eugênio Garcez- Assessment of the quality of life, muscle strength, and dynamic balance of elderly Kendo players(2017) MENDONCA, Dario Lucas Costa de; ALONSO, Angelica Castilho; GREVE, Julia Maria D'Andrea; GARCEZ-LEME, Luiz EugenioOBJECTIVE: To compare Kendo players with active elderly adults in terms of quality of life, functional aspects (muscle strength, postural balance) and body composition. METHODS: This was a controlled cross-sectional study. Twenty elderly individuals were divided into two groups: the Kendo group, with an average age of 71.8 (5.4) years, and the Control group, with an average age of 73.1 (4.8) years. Quality of life was evaluated using a questionnaire (WHOQOL-bref and WHOQOL-old); body composition was evaluated with a bioimpedance scale (InBody230); hand-grip strength was assessed with a portable manual dynamometer (Jamar SH 5001); flexor and extensor muscle strength of the knees was evaluated with an isokinetic device (Biodex (R) System 3 model Biodex Multi Joint System, BIODEX); and dynamic balance was assessed using a force platform (Balance Master System, Neurocom International, Inc.(R) Clackamas County, Oregon, USA). RESULTS: The groups were statistically homogeneous in terms of socio-demographic characterization, body composition, muscle strength, and dynamic balance, but the Control group was faster in the sit-to-stand test (p=0.03). The Kendo group had a statistically significantly better quality of life; in the WHOQOL-bref, these differences were present in the physical (p <= 0.001) and environment (p=0.004) domains, and in the WHOQOL-old, these differences were present in social participation (p=0.001) and in past, present, and future activities (p=0.019). CONCLUSION: The results suggest that Kendo is a health-promoting activity that improves the quality of life, functional aspects (muscle strength and postural balance) and body composition of players.