CLARISSE MARTINS MACHADO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina
LIM/52 - Laboratório de Virologia, Hospital das Clínicas, Faculdade de Medicina
LIM/52 - Laboratório de Virologia, Hospital das Clínicas, Faculdade de Medicina
7 resultados
Resultados de Busca
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conferenceObject Revisiting viral surveillance in haploidentical stem cell transplantation (haploSCT). A case-control study(2018) COLTURATO, Iago; MORENO, Juliana P.; ZANETTI, Lilian P.; OLIVEIRA, Leila C. S. de; FRANCESCHI, Fernanda S.; SABAINI, Carlos S.; SANTOS, Ana Claudia F. dos; SILVA, Paula M. da; SOUZA, Mair P. de; COLTURATO, Vergilio R.; MACHADO, Clarisse M.conferenceObject PRE-EMPTIVE RITUXIMAB FOR EBV REACTIVATION IN TIMES OF COVID-19: IS IT REALLY NECESSARY?(2023) SANTOS, Ana Claudia Ferrari dos; SIMIONE, Anderson Joao; SOUZA, Anna Beatriz Coelho de; MORENO, Juliana Ribeiro do Prado; ZANETTI, Lilian Perilio; OLIVEIRA, Leila Cibele Serra; COLTURATO, Iago; BARBIERI, Fernanda Rodrigues; SANTOS, Juliana Silva; DELATTRE, Erika Rodrigues Pontes; MASCARENHAS, Carolina Ferreira; PEGORARI, Leticia Galbier Ricetto; SOUZA, Mair Pedro de; COLTURATO, Vergilio Antonio Rensi; MACHADO, Clarisse Martins- COVID-19 in HSCT recipients: a collaborative study of the Brazilian Society of Marrow Transplantation (SBTMO)(2022) DAUDT, Liane Esteves; CORSO, Mariana Cristina Moraes; KERBAUY, Mariana Nassif; ASSIS, Luiz Henrique dos Santos de; RECHENMACHER, Ciliana; COLTURATO, Iago; BARBIERI, Fernanda Rodrigues; ROCHA, Vanderson; MARIANO, Livia; GARCIA, Julia Lopes; DANTAS, Vanessa Esther Cavalcanti Barreto; LOTH, Gisele; FUNKE, Vaneuza Araujo Moreira; PELEGRINA, Polliany Roberta Dorini; DUARTE, Fernando Barroso; SILVA, Roberto Luiz da; ARAUJO, Marco Aurelio Salvino; CARLESSE, Fabianne Altruda de Moraes Costa; SOUSA, Ana Virginia Lopes de; MAIA, Luana Azevedo; FERNANDES, Juliana Folloni; RODRIGUES, Celso Arrais; BONFIM, Carmem; MARTINS, Leticia Navarro Gordan Ferreira; CIPOLOTTI, Rosana; XAVIER, Erick Menezes; GOMES, Alessandra Araujo; MORALES, Hugo Manuel Paz; SIMIONI, Anderson J.; SOARES, Victor Jablonski; MICHALOWSKI, Mariana Bohns; HAMERSCHLAK, Nelson; MACHADO, Clarisse MartinsIn the COVID-19 scenario, patients undergoing hematopoietic stem cell transplantation (HSCT) infected with SARS-CoV-2 may have an increased risk of death. Through a national multicenter study, we aimed to describe the impact of COVID-19 on the survival of HSCT recipients in Brazil. Eighty-six patients with a confirmed diagnosis of SARS-CoV-2 (92% by RT-PCR) were included. There were 24 children and 62 adults receiving an autologous (n = 25) and allogeneic (n = 61) HSCT for malignant (n = 72) and non-malignant (n = 14) disorders. Twenty-six patients died, (10 on autologous (38%) and 16 patients (62%) on allogeneic group). The estimated overall survival (OS) at day 40 was 69%. Adults had decreased OS compared to children (66% vs 79%, p = 0.03). The severity of symptoms at the time of diagnosis, ECOG score, laboratory tests (C-reactive protein, urea values) were higher in patients who died (p < 0.05). In conclusion, HSCT recipients infected with SARS-CoV-2 have a high mortality rate mainly in adults and patients with critical initial COVID-19 presentation. These findings show the fragility of HSCT recipients with SARS-CoV-2 infection. Therefore, the importance of adherence to preventive measures is evident, in addition to prioritizing the vaccination of family members and the HSCT team.
- Compliance with yellow fever and measles vaccines in the revaccination program post-hematopoietic cell transplantation(2023) TESTA, Lucia H. de Almeida H.; SIMIONE, Anderson J.; SANTOS, Ana Claudia F. dos; COLTURATO, Iago; BARBIERI, Fernanda; SOUZA, Mair Pedro de; COLTURATO, Vergilio R.; MACHADO, Clarisse M.Introduction: Measles, mumps, rubella, and even poliomyelitis outbreaks have recently perplexed infectious disease clinicians and epidemiologists globally due to the decline in vaccination coverage rates in children and adults. Measles and yellow fever (YF) have represented an increasing burden on the Brazilian public health system in recent decades. Both diseases are preventable by live-attenuated viral vaccines (LAVV), which have restricted use in hematopoietic cell transplant (HCT) recipients.Methods: Autologous and allogeneic HCT recipients returning for regular appointments at the outpatient clinic were invited to participate in the study. Patients transplanted for at least 2 years and with a printed copy of the vaccination record were included.Results: We assessed the vaccination records of 273 HCT recipients after the second year of HCT (193 allogeneic and 80 autologous) and observed lower compliance with the YF vaccine (58 patients, 21.2%) than with the measles vaccine (138 patients, 50.5%, p = .0001). This is the largest published series of YF vaccination in HCT recipients so far. No severe adverse events occurred. Although expected, chronic graft-versus-host disease (GVHD) did not affect the compliance with measles (p = .08) or YF vaccination (p = .7). Indeed, more allogeneic recipients received measles vaccine in comparison with autologous patients (p < .0001), suggesting that chronic GVHD was not the main reason for not being vaccinated. Children and allogeneic HCT were more likely to receive measles vaccine. Time elapsed from HCT >5 years favored both measles and YF vaccination.Conclusion: A better understanding of the reasons for low compliance with LAVV is necessary to overcome this problem.
conferenceObject RSV infection in HSCT recipients: Experience from one single center(2019) SOUZA, Anna Beatriz C. de; SILVA, Paula Moreira da; SILVA, Gustavo Fernandes; SIMIONI, Anderson Joao; ZANETTI, Lilian Perilio; MORENO, Juliana R. Do Prado; OLIVEIRA, Leila Cibele S. de; COLTURATO, Iago; FRANCESCHI, Fernada Leite de Souza; SANTOS, Ana Claudia Ferrari dos; ADATI, Elen Monteiro; SOUZA, Mair Pedro de; COLTURATO, Vergilio Antonio Rensi; MACHADO, Clarisse MartinsconferenceObject Development and Application of a Software to Improve the Data Management of a Bone Marrow Transplant Service in a Brazilian Public Hospital(2019) SIMIONE, Anderson Joao; SONA, Bruna Fernanda; POSSANI, Valquiria de Cassia; COLTURATO, Iago; FRANCESCHI, Fernanda Leite de Souza; BARBIERI, Fernanda Rodrigues; MACHADO, Clarisse Martins; SR., Vergilio A. R. Colturato; SOUZA, Mair Pedro De; SILVA, Paula Moreira daconferenceObject Influenza A and B infection are clinically similar in HSCT recipients(2018) SABAINI, Carlos S.; SIMINONE, Anderson J.; SILVA, Paula M. da; ZANETTI, Lilian P.; OLIVEIRA, Leila C. S. de; SOUZA, Marina de Oliveira e; MORENO, Juliana P.; FRANCESCHI, Fernanda S.; COLTURATO, Iago; SOUZA, Mair P.; COLTURATO, Vergilio R.; MACHADO, Clarisse M.