CLARISSE MARTINS MACHADO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina
LIM/52 - Laboratório de Virologia, Hospital das Clínicas, Faculdade de Medicina
LIM/52 - Laboratório de Virologia, Hospital das Clínicas, Faculdade de Medicina
4 resultados
Resultados de Busca
Agora exibindo 1 - 4 de 4
- Zika and chikungunya virus infections in hematopoietic stem cell transplant recipients and oncohematological patients(2017) MACHADO, Clarisse Martins; PEREIRA, Barbara Brito de Souza; FELIX, Alvina Clara; OLIVEIRA, Maria Carolina; DARRIGO JR., Luiz Guilherme; SOUZA, Mair Pedro de; PATON, Eduardo Jose de Alencar; NEVES, Fabia; COLTURATO, Vergilio Rensi; SIMOES, Belinda PintoAedes mosquitoes are well adapted in domestic environments and widespread in tropical regions. Since 2015, Brazil has been experiencing a triple epidemic of dengue (DENV), chikungunya (CHKV), and Zika (ZIKV) viruses. The last 2 viruses are likely following the path of DENV, which has been endemic in most parts of the country since the 1980s. Given this triple epidemic, we proposed a prospective and collaborative study to assess the prevalence, morbidity, andmortality of DENV, CHKV, and ZIKV infections in hematopoietic stem cell transplant (HSCT) recipients and oncohematological patients. A case definition strategy (fever and rash) was used to prompt diagnostic investigation of DENV, ZIKV, and CHKV, which was accomplished by real-time polymerase chain reaction with plasma and urine samples. Clinical follow-up was performed 7 and 30 days after symptom onset. We report here the first cases of ZIKV and CHKV infections diagnosed in this ongoing study. From February to May 2016, 9 of the 26 patients (34.6%) fulfilling case definition criteria were diagnosed with DENV (3 cases), ZIKV (4 cases), or CHKV (2 cases) infections. Prolonged viremia and viruria were observed in dengue and Zika fever cases, respectively. Thrombocytopenia was the most frequent complication. Delayed engraftment was noted in 1 patient who acquired ZIKV 25 days before HSCT. All patients survived without sequelae. With the geographic expansion of arboviruses, donor and recipient screening may become mandatory. Patients living in areas where these viruses are not endemic are also at risk, since these viruses can be transmitted by blood as well as organ or tissue transplantation
- Cut-Off of COBAS (R) Ampliprep/COBAS (R) Taqman (R) CMV Test in Transplant Recipients Receiving Intermittent Ganciclovir (GCV) Prophylaxis(2018) CAMPOS, Silvia Vidal; SOUZA, Ana Carolina M.; MELLO, Liliane S.; PEREIRA, Barbara B. S.; MACHADO, Clarisse M.
conferenceObject Clinical Assessment of Cytomegalovirus Specific Cell Mediated Immunity in a Prospective Cohort of Lung Transplant Recipients(2017) CAMPOS, S. V.; SAMANO, M. N.; PEGO-FERNANDES, P. M.; TEIXEIRA, R. O.; CARRARO, R. M.; AFONSO-JUNIOR, J. E.; COSTA, A. N.; MACHADO, C. M.; SOUZA, A. C.; PEREIRA, B. B.; FERNANDES, L. M.; ABDALLA, L.- Prolonged viremia in dengue virus infection in hematopoietic stem cell transplant recipients and patients with hematological malignancies(2017) PEREIRA, Barbara Brito de Souza; DARRIGO JUNIOR, Luiz Guilherme; COSTA, Thalita Cristina de Mello; FELIX, Alvina Clara; SIMOES, Belinda P.; STRACIERI, Ana Beatriz; SILVA, Paula Moreira da; MAUAD, Marcos; MACHADO, Clarisse M.Fever, skin rash, headache, and thrombocytopenia are considered hallmarks of dengue infection. However, these symptoms are frequently observed in infectious and non-infectious complications of hematopoietic stem cell transplant recipients and oncohematological patients. Thus, laboratory confirmation of dengue is relevant for prompt intervention and proper management of dengue in endemic and non-endemic regions. Because no prospective study of dengue has been conducted in these populations, the actual morbidity and mortality of dengue is unknown. In the present series, we describe five cases of dengue in patients living in endemic areas, emphasizing the prolonged course of the disease and the occurrence of prolonged viremia.