CLARISSE MARTINS MACHADO

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Departamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina
LIM/52 - Laboratório de Virologia, Hospital das Clínicas, Faculdade de Medicina

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  • article 4 Citação(ões) na Scopus
    Endemic or regionally limited parasitic and fungal infections in haematopoietic stem-cell transplantation recipients: a Worldwide Network for Blood and Marrow Transplantation (WBMT) Review
    (2023) MUHSEN, Ibrahim N.; GALEANO, Sebastian; NIEDERWIESER, Dietger; KOH, Mickey B. C.; LJUNGMAN, Per; MACHADO, Clarisse M.; KHARFAN-DABAJA, Mohamed A.; CAMARA, Rafael de la; KODERA, Yoshihisa; SZER, Jeff; RASHEED, Walid; CESARO, Simone; HASHMI, Shahrukh K.; SEBER, Adriana; ATSUTA, Yoshiko; SALEH, Mostafa F. Mohammed; SRIVASTAVA, Alok; STYCZYNSKI, Jan; ALRAJHI, Abdulrahman; ALMAGHRABI, Reem; ABID, Muhammad Bilal; CHEMALY, Roy F.; GERGIS, Usama; BRISSOT, Eolia; FAKIH, Riad El; RICHES, Marcie; MIKULSKA, Malgorzata; WOREL, Nina; WEISDORF, Daniel; GREINIX, Hildegard; CORDONNIER, Catherine; ALJURF, Mahmoud
    There is a scarcity of data on endemic and regionally limited fungal and parasitic infections in recipients of haematopoietic stem-cell transplantation (HSCT) outside western Europe and North America. This Worldwide Network for Blood and Marrow Transplantation (WBMT) Review is one of two papers aiming to provide guidance to transplantation centres worldwide regarding prevention, diagnosis, and treatment based on the currently available evidence and expert opinion. These recommendations were created and reviewed by physicians with expertise in HSCT or infectious disease, representing several infectious disease and HSCT groups and societies. In this paper, we review the literature on several endemic and regionally limited parasitic and fungal infections, some of which are listed as neglected tropical diseases by WHO, including visceral leishmaniasis, Chagas disease, strongyloidiasis, malaria, schistosomiasis, histoplasmosis, blastomycosis, and coccidioidomycosis.
  • article 2 Citação(ões) na Scopus
    Epidemiology, treatment patterns, and disease burden of cytomegalovirus in hematopoietic cell transplant recipients in selected countries outside of Europe and North America: A systematic review
    (2023) CHO, Sung-Yeon; AR, Muhlis Cem; MACHADO, Clarisse M.; WU, Depei; SINGH, Inderjeet; SANDHU, Anudeep; DEMUTH, Dirk; SLAVIN, Monica
    Background: Cytomegalovirus (CMV) disease impacts morbidity and mortality in hematopoietic cell transplant (HCT) recipients. This systematic review summarized data on the epidemiology, management, and burden of CMV post-HCT outside of Europe and North America.Methods: The MEDLINE, Embase, and Cochrane databases were searched for observational studies and treatment guidelines in HCT recipients across 15 selected countries from Asia-Pacific, Latin America, and Middle East (search period: 1 January 2011-17 September 2021). Outcomes included incidence of CMV infection/disease, recurrence, risk factors, CMV-related mortality, treatments, refractory, resistant CMV, and burden.Results: Of 2708 references identified, 68 were eligible (67 studies and one guideline; 45/67 studies specific to adult allogeneic HCT recipients). The rates of CMV infection and disease within 1 year of allogeneic HCT were 24.9%-61.2% (23 studies) and 2.9%-15.7% (10 studies), respectively. Recurrence occurred in 19.8%-37.9% of cases (11 studies). Up to 10% of HCT recipients died of CMV-related causes. In all countries, first-line treatment for CMV infection/disease involved intravenous ganciclovir or valganciclovir. Conventional treatments were associated with serious adverse events such as myelosuppression (10.0%) or neutropenia only (30.0%, 39.8%) and nephrotoxicity (11.0%) (three studies), frequently leading to treatment discontinuation (up to 13.6%). Refractory CMV was reported in 2.9%, 13.0%, and 28.9% of treated patients (three studies) with resistant CMV diagnosed in 0%-10% of recipients (five studies). Patient-reported outcomes and economic data were scarce.Conclusion: The incidence of CMV infection and disease post-HCT is high outside of North America and Europe. CMV resistance and toxicity highlight a major unmet need with current conventional treatments.
  • conferenceObject
    Epidemiology of Cytomegalovirus Infection and Disease in Hematopoietic Stem Cell Transplant Recipients in Selected Countries Outside of North America and Europe: A Systematic Review
    (2022) MACHADO, Clarisse M.; CHO, Sung-Yeon; SLAVIN, Monica; SINGH, Inderjeet; SANDHU, Anudeep; DEMUTH, Dirk; WU, Depei
  • article 2 Citação(ões) na Scopus
    Endemic or regionally limited bacterial and viral infections in haematopoietic stem-cell transplantation recipients: a Worldwide Network for Blood and Marrow Transplantation (WBMT) Review
    (2023) MUHSEN, Ibrahim N.; GALEANO, Sebastian; NIEDERWIESER, Dietger; KOH, Mickey B. C.; LJUNGMAN, Per; MACHADO, Clarisse M.; KHARFAN-DABAJA, Mohamed A.; CAMARA, Rafael de la; KODERA, Yoshihisa; SZER, Jeff; RASHEED, Walid; CESARO, Simone; HASHMI, Shahrukh K.; SEBER, Adriana; ATSUTA, Yoshiko; SALEH, Mostafa F. Mohammed; SRIVASTAVA, Alok; STYCZYNSKI, Jan; ALRAJHI, Abdulrahman; ALMAGHRABI, Reem; ABID, Muhammad Bilal; CHEMALY, Roy F.; GERGIS, Usama; BRISSOT, Eolia; FAKIH, Riad El; RICHES, Marcie; MIKULSKA, Malgorzata; WOREL, Nina; WEISDORF, Daniel; GREINIX, Hildegard; CORDONNIER, Catherine; ALJURF, Mahmoud
    Literature discussing endemic and regionally limited infections in recipients of haematopoietic stem-cell transplantation (HSCT) outside western Europe and North America is scarce. This Worldwide Network for Blood and Marrow Transplantation (WBMT) article is part one of two papers aiming to provide guidance to transplantation centres around the globe regarding infection prevention and treatment, and considerations for transplantation based on current evidence and expert opinion. These recommendations were initially formulated by a core writing team from the WBMT and subsequently underwent multiple revisions by infectious disease experts and HSCT experts. In this paper, we summarise the data and provide recommendations on several endemic and regionally limited viral and bacterial infections, many of which are listed by WHO as neglected tropical diseases, including Dengue, Zika, yellow fever, chikungunya, rabies, brucellosis, melioidosis, and leptospirosis.
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