CLARISSE MARTINS MACHADO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina
LIM/52 - Laboratório de Virologia, Hospital das Clínicas, Faculdade de Medicina
LIM/52 - Laboratório de Virologia, Hospital das Clínicas, Faculdade de Medicina
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conferenceObject SARS CoV-2 infection and covid-19 in health care workers from a hematopoietic stem cell transplant (HSCT) unit before and after vaccination: A prospective cohort study(2022) SANTOS, A. C. Ferrari dos; MORENO, J. Do Prado; ZANETTI, L. Perilio; OLIVEIRA, L. C. de; TESTA, L. H. de Almeida; SIMIONE, A. J.; SOUZA, M. P. de; COLTURATO, V. A. Rensi; MACHADO, C.conferenceObject Revisiting viral surveillance in haploidentical stem cell transplantation (haploSCT). A case-control study(2018) COLTURATO, Iago; MORENO, Juliana P.; ZANETTI, Lilian P.; OLIVEIRA, Leila C. S. de; FRANCESCHI, Fernanda S.; SABAINI, Carlos S.; SANTOS, Ana Claudia F. dos; SILVA, Paula M. da; SOUZA, Mair P. de; COLTURATO, Vergilio R.; MACHADO, Clarisse M.conferenceObject PRE-TRANSPLANT DONOR AND RECIPIENT INFLUENZA VACCINATION ENHANCES SERO-RESPONSE RATES IN THE FIRST SIX MONTHS AFTER HSCT(2014) AMBATI, A.; TESTA, L.; LJUNGMAN, P.; BOAS, L. S. Vilas; AOUN, M.; MAEURER, M.; MACHADO, C.conferenceObject PRE-EMPTIVE RITUXIMAB FOR EBV REACTIVATION IN TIMES OF COVID-19: IS IT REALLY NECESSARY?(2023) SANTOS, Ana Claudia Ferrari dos; SIMIONE, Anderson Joao; SOUZA, Anna Beatriz Coelho de; MORENO, Juliana Ribeiro do Prado; ZANETTI, Lilian Perilio; OLIVEIRA, Leila Cibele Serra; COLTURATO, Iago; BARBIERI, Fernanda Rodrigues; SANTOS, Juliana Silva; DELATTRE, Erika Rodrigues Pontes; MASCARENHAS, Carolina Ferreira; PEGORARI, Leticia Galbier Ricetto; SOUZA, Mair Pedro de; COLTURATO, Vergilio Antonio Rensi; MACHADO, Clarisse Martins- Evaluation of pretransplant influenza vaccination in hematopoietic SCT: a randomized prospective study(2015) AMBATI, A.; BOAS, L. S. V.; LJUNGMAN, P.; TESTA, L.; OLIVEIRA, J. F. de; AOUN, M.; COLTURATO, V.; MAEURER, M.; MACHADO, C. M.Pretransplant influenza vaccination of the donor or allogeneic hematopoietic SCT (HSCT) candidate was evaluated in a randomized study. One hundred and twenty-two HSCT recipients and their donors were assigned to three randomization groups: no pretransplant vaccination (n = 38), donor pretransplant vaccination (n = 44) or recipient pretransplant vaccination (n = 40). Specific IgG was assessed by both hemagglutinin inhibition (HI) and, in 57 patients, by an indirect influenza-specific ELISA at specified times after HSCT. Vaccinated donors had seroprotective HI titers for Ags H1 and H3 (P<0.001) compared with the other groups at the time of donation. The titers against H1 (P = 0.028) and H3 (P<0.001) were highest in the pretransplant recipient vaccination group until day 180 after transplantation. A significant difference was found in the specific Ig levels against pandemic H1N1 at 6 months after SCT (P = 0.02). The mean IgG levels against pandemic H1N1 and generic H1N1 and H3N2 were highest in the pretransplant recipient vaccination group. We conclude that pretransplant recipient vaccination improved the influenza-specific seroprotection rates.
- Latent and active tuberculosis infection in allogeneic hematopoietic stem cell transplant recipients: a prospective cohort study(2021) RODRIGUES, Marina de Oliveira; TESTA, Lucia H. de Almeida; SANTOS, Ana Claudia F. dos; ZANETTI, Lilian P.; RUIZ, Luciana da Silva; SOUZA, Mair Pedro de; COLTURATO, Vergilio R.; MACHADO, Clarisse M.Tuberculosis (TB) is a major infectious complication in hematopoietic stem cell transplant (HSCT) recipients in countries with high TB prevalence. Identifying and treating latent tuberculosis infection (LTBI) helps to prevent TB reactivation after transplantation. Few studies have compared the tuberculin skin test (TST) with interferon Gamma release assays (IGRA) to diagnose LTBI in HSCT candidates. We compared TST and QuantiFeron TB gold in tube (QTF-GIT) and prospectively evaluated the incidence of active tuberculosis in 126 HSCT candidates and 58 HSCT recipients with chronic GVHD followed at the outpatient clinic. TB was diagnosed by culture in Mycobacteria media and by commercial real-time PCR kit. Considering the positivity of any test, the prevalence of LTBI was 8.7% in HSCT candidates (11 out of 126) and 12.5% in HSCT recipients with chronic GVHD (6 out of 48). QTF-GIT indeterminate results were detected in 2.4% of the HSCT candidates. Fair to good agreement (K > 0.50) between tests was observed in both cohorts. Cumulative incidence of TB was 3% in the GVHD cohort. TB was diagnosed in 2 chronic GVHD recipients, both cases confirmed by positive culture and PCR. None of the 11 patients with LTBI diagnosed pre-HSCT who received INH prophylaxis developed TB.
- COVID-19 in HSCT recipients: a collaborative study of the Brazilian Society of Marrow Transplantation (SBTMO)(2022) DAUDT, Liane Esteves; CORSO, Mariana Cristina Moraes; KERBAUY, Mariana Nassif; ASSIS, Luiz Henrique dos Santos de; RECHENMACHER, Ciliana; COLTURATO, Iago; BARBIERI, Fernanda Rodrigues; ROCHA, Vanderson; MARIANO, Livia; GARCIA, Julia Lopes; DANTAS, Vanessa Esther Cavalcanti Barreto; LOTH, Gisele; FUNKE, Vaneuza Araujo Moreira; PELEGRINA, Polliany Roberta Dorini; DUARTE, Fernando Barroso; SILVA, Roberto Luiz da; ARAUJO, Marco Aurelio Salvino; CARLESSE, Fabianne Altruda de Moraes Costa; SOUSA, Ana Virginia Lopes de; MAIA, Luana Azevedo; FERNANDES, Juliana Folloni; RODRIGUES, Celso Arrais; BONFIM, Carmem; MARTINS, Leticia Navarro Gordan Ferreira; CIPOLOTTI, Rosana; XAVIER, Erick Menezes; GOMES, Alessandra Araujo; MORALES, Hugo Manuel Paz; SIMIONI, Anderson J.; SOARES, Victor Jablonski; MICHALOWSKI, Mariana Bohns; HAMERSCHLAK, Nelson; MACHADO, Clarisse MartinsIn the COVID-19 scenario, patients undergoing hematopoietic stem cell transplantation (HSCT) infected with SARS-CoV-2 may have an increased risk of death. Through a national multicenter study, we aimed to describe the impact of COVID-19 on the survival of HSCT recipients in Brazil. Eighty-six patients with a confirmed diagnosis of SARS-CoV-2 (92% by RT-PCR) were included. There were 24 children and 62 adults receiving an autologous (n = 25) and allogeneic (n = 61) HSCT for malignant (n = 72) and non-malignant (n = 14) disorders. Twenty-six patients died, (10 on autologous (38%) and 16 patients (62%) on allogeneic group). The estimated overall survival (OS) at day 40 was 69%. Adults had decreased OS compared to children (66% vs 79%, p = 0.03). The severity of symptoms at the time of diagnosis, ECOG score, laboratory tests (C-reactive protein, urea values) were higher in patients who died (p < 0.05). In conclusion, HSCT recipients infected with SARS-CoV-2 have a high mortality rate mainly in adults and patients with critical initial COVID-19 presentation. These findings show the fragility of HSCT recipients with SARS-CoV-2 infection. Therefore, the importance of adherence to preventive measures is evident, in addition to prioritizing the vaccination of family members and the HSCT team.
conferenceObject RSV infection in HSCT recipients: Experience from one single center(2019) SOUZA, Anna Beatriz C. de; SILVA, Paula Moreira da; SILVA, Gustavo Fernandes; SIMIONI, Anderson Joao; ZANETTI, Lilian Perilio; MORENO, Juliana R. Do Prado; OLIVEIRA, Leila Cibele S. de; COLTURATO, Iago; FRANCESCHI, Fernada Leite de Souza; SANTOS, Ana Claudia Ferrari dos; ADATI, Elen Monteiro; SOUZA, Mair Pedro de; COLTURATO, Vergilio Antonio Rensi; MACHADO, Clarisse MartinsconferenceObject Influenza A and B infection are clinically similar in HSCT recipients(2018) SABAINI, Carlos S.; SIMINONE, Anderson J.; SILVA, Paula M. da; ZANETTI, Lilian P.; OLIVEIRA, Leila C. S. de; SOUZA, Marina de Oliveira e; MORENO, Juliana P.; FRANCESCHI, Fernanda S.; COLTURATO, Iago; SOUZA, Mair P.; COLTURATO, Vergilio R.; MACHADO, Clarisse M.conferenceObject DAY 30 MORTALITY OF ASYMPTOMATIC HSCT RECIPIENTS WITH RESPIRATORY VIRUS INFECTION DETECTED BY MULTIPLEX PCR IN RESPIRATORY SAMPLES TAKEN IMMEDIATELY BEFORE TRANSPLANTATION(2014) SOUZA, M. Oliveira; ZANETTI, L. Perilio; SILVA, P. Moreira; SANTOS, A. C. Ferrari dos; SOUZA, A. C. Mamana; COLTURATO, V. Rensi; MACHADO, C.