CLARISSE MARTINS MACHADO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina
LIM/52 - Laboratório de Virologia, Hospital das Clínicas, Faculdade de Medicina
LIM/52 - Laboratório de Virologia, Hospital das Clínicas, Faculdade de Medicina
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conferenceObject SARS CoV-2 infection and covid-19 in health care workers from a hematopoietic stem cell transplant (HSCT) unit before and after vaccination: A prospective cohort study(2022) SANTOS, A. C. Ferrari dos; MORENO, J. Do Prado; ZANETTI, L. Perilio; OLIVEIRA, L. C. de; TESTA, L. H. de Almeida; SIMIONE, A. J.; SOUZA, M. P. de; COLTURATO, V. A. Rensi; MACHADO, C.- Endemic or regionally limited parasitic and fungal infections in haematopoietic stem-cell transplantation recipients: a Worldwide Network for Blood and Marrow Transplantation (WBMT) Review(2023) MUHSEN, Ibrahim N.; GALEANO, Sebastian; NIEDERWIESER, Dietger; KOH, Mickey B. C.; LJUNGMAN, Per; MACHADO, Clarisse M.; KHARFAN-DABAJA, Mohamed A.; CAMARA, Rafael de la; KODERA, Yoshihisa; SZER, Jeff; RASHEED, Walid; CESARO, Simone; HASHMI, Shahrukh K.; SEBER, Adriana; ATSUTA, Yoshiko; SALEH, Mostafa F. Mohammed; SRIVASTAVA, Alok; STYCZYNSKI, Jan; ALRAJHI, Abdulrahman; ALMAGHRABI, Reem; ABID, Muhammad Bilal; CHEMALY, Roy F.; GERGIS, Usama; BRISSOT, Eolia; FAKIH, Riad El; RICHES, Marcie; MIKULSKA, Malgorzata; WOREL, Nina; WEISDORF, Daniel; GREINIX, Hildegard; CORDONNIER, Catherine; ALJURF, MahmoudThere is a scarcity of data on endemic and regionally limited fungal and parasitic infections in recipients of haematopoietic stem-cell transplantation (HSCT) outside western Europe and North America. This Worldwide Network for Blood and Marrow Transplantation (WBMT) Review is one of two papers aiming to provide guidance to transplantation centres worldwide regarding prevention, diagnosis, and treatment based on the currently available evidence and expert opinion. These recommendations were created and reviewed by physicians with expertise in HSCT or infectious disease, representing several infectious disease and HSCT groups and societies. In this paper, we review the literature on several endemic and regionally limited parasitic and fungal infections, some of which are listed as neglected tropical diseases by WHO, including visceral leishmaniasis, Chagas disease, strongyloidiasis, malaria, schistosomiasis, histoplasmosis, blastomycosis, and coccidioidomycosis.
conferenceObject Use of Adhesive Tags as a Facilitating Tool in the Data Report of Chronic Gvhd in a HSCT Center Lacking Electronic Medical Records(2018) SILVA, Paula Moreira da; SIMIONE, Anderson Joao; SONA, Bruna Fernanda; COLTURATO, Lag; MAUAD, Lenira Maria Queiroz; SANTOS, Ana Claudia Ferrari dos; MACHADO, Clarisse Martins; POSSANI, Valquiria de Cassia; FRANCESCHI, Fernanda Leite de Souza; SABAINI, Carlos Sitta; COLTURATO, Vergilio A. R.; SOUZA, Mair Pedro DeconferenceObject Revisiting viral surveillance in haploidentical stem cell transplantation (haploSCT). A case-control study(2018) COLTURATO, Iago; MORENO, Juliana P.; ZANETTI, Lilian P.; OLIVEIRA, Leila C. S. de; FRANCESCHI, Fernanda S.; SABAINI, Carlos S.; SANTOS, Ana Claudia F. dos; SILVA, Paula M. da; SOUZA, Mair P. de; COLTURATO, Vergilio R.; MACHADO, Clarisse M.conferenceObject PRE-TRANSPLANT DONOR AND RECIPIENT INFLUENZA VACCINATION ENHANCES SERO-RESPONSE RATES IN THE FIRST SIX MONTHS AFTER HSCT(2014) AMBATI, A.; TESTA, L.; LJUNGMAN, P.; BOAS, L. S. Vilas; AOUN, M.; MAEURER, M.; MACHADO, C.- Zika and chikungunya virus infections in hematopoietic stem cell transplant recipients and oncohematological patients(2017) MACHADO, Clarisse Martins; PEREIRA, Barbara Brito de Souza; FELIX, Alvina Clara; OLIVEIRA, Maria Carolina; DARRIGO JR., Luiz Guilherme; SOUZA, Mair Pedro de; PATON, Eduardo Jose de Alencar; NEVES, Fabia; COLTURATO, Vergilio Rensi; SIMOES, Belinda PintoAedes mosquitoes are well adapted in domestic environments and widespread in tropical regions. Since 2015, Brazil has been experiencing a triple epidemic of dengue (DENV), chikungunya (CHKV), and Zika (ZIKV) viruses. The last 2 viruses are likely following the path of DENV, which has been endemic in most parts of the country since the 1980s. Given this triple epidemic, we proposed a prospective and collaborative study to assess the prevalence, morbidity, andmortality of DENV, CHKV, and ZIKV infections in hematopoietic stem cell transplant (HSCT) recipients and oncohematological patients. A case definition strategy (fever and rash) was used to prompt diagnostic investigation of DENV, ZIKV, and CHKV, which was accomplished by real-time polymerase chain reaction with plasma and urine samples. Clinical follow-up was performed 7 and 30 days after symptom onset. We report here the first cases of ZIKV and CHKV infections diagnosed in this ongoing study. From February to May 2016, 9 of the 26 patients (34.6%) fulfilling case definition criteria were diagnosed with DENV (3 cases), ZIKV (4 cases), or CHKV (2 cases) infections. Prolonged viremia and viruria were observed in dengue and Zika fever cases, respectively. Thrombocytopenia was the most frequent complication. Delayed engraftment was noted in 1 patient who acquired ZIKV 25 days before HSCT. All patients survived without sequelae. With the geographic expansion of arboviruses, donor and recipient screening may become mandatory. Patients living in areas where these viruses are not endemic are also at risk, since these viruses can be transmitted by blood as well as organ or tissue transplantation
conferenceObject PRE-EMPTIVE RITUXIMAB FOR EBV REACTIVATION IN TIMES OF COVID-19: IS IT REALLY NECESSARY?(2023) SANTOS, Ana Claudia Ferrari dos; SIMIONE, Anderson Joao; SOUZA, Anna Beatriz Coelho de; MORENO, Juliana Ribeiro do Prado; ZANETTI, Lilian Perilio; OLIVEIRA, Leila Cibele Serra; COLTURATO, Iago; BARBIERI, Fernanda Rodrigues; SANTOS, Juliana Silva; DELATTRE, Erika Rodrigues Pontes; MASCARENHAS, Carolina Ferreira; PEGORARI, Leticia Galbier Ricetto; SOUZA, Mair Pedro de; COLTURATO, Vergilio Antonio Rensi; MACHADO, Clarisse Martins- Evaluation of pretransplant influenza vaccination in hematopoietic SCT: a randomized prospective study(2015) AMBATI, A.; BOAS, L. S. V.; LJUNGMAN, P.; TESTA, L.; OLIVEIRA, J. F. de; AOUN, M.; COLTURATO, V.; MAEURER, M.; MACHADO, C. M.Pretransplant influenza vaccination of the donor or allogeneic hematopoietic SCT (HSCT) candidate was evaluated in a randomized study. One hundred and twenty-two HSCT recipients and their donors were assigned to three randomization groups: no pretransplant vaccination (n = 38), donor pretransplant vaccination (n = 44) or recipient pretransplant vaccination (n = 40). Specific IgG was assessed by both hemagglutinin inhibition (HI) and, in 57 patients, by an indirect influenza-specific ELISA at specified times after HSCT. Vaccinated donors had seroprotective HI titers for Ags H1 and H3 (P<0.001) compared with the other groups at the time of donation. The titers against H1 (P = 0.028) and H3 (P<0.001) were highest in the pretransplant recipient vaccination group until day 180 after transplantation. A significant difference was found in the specific Ig levels against pandemic H1N1 at 6 months after SCT (P = 0.02). The mean IgG levels against pandemic H1N1 and generic H1N1 and H3N2 were highest in the pretransplant recipient vaccination group. We conclude that pretransplant recipient vaccination improved the influenza-specific seroprotection rates.
- Latent and active tuberculosis infection in allogeneic hematopoietic stem cell transplant recipients: a prospective cohort study(2021) RODRIGUES, Marina de Oliveira; TESTA, Lucia H. de Almeida; SANTOS, Ana Claudia F. dos; ZANETTI, Lilian P.; RUIZ, Luciana da Silva; SOUZA, Mair Pedro de; COLTURATO, Vergilio R.; MACHADO, Clarisse M.Tuberculosis (TB) is a major infectious complication in hematopoietic stem cell transplant (HSCT) recipients in countries with high TB prevalence. Identifying and treating latent tuberculosis infection (LTBI) helps to prevent TB reactivation after transplantation. Few studies have compared the tuberculin skin test (TST) with interferon Gamma release assays (IGRA) to diagnose LTBI in HSCT candidates. We compared TST and QuantiFeron TB gold in tube (QTF-GIT) and prospectively evaluated the incidence of active tuberculosis in 126 HSCT candidates and 58 HSCT recipients with chronic GVHD followed at the outpatient clinic. TB was diagnosed by culture in Mycobacteria media and by commercial real-time PCR kit. Considering the positivity of any test, the prevalence of LTBI was 8.7% in HSCT candidates (11 out of 126) and 12.5% in HSCT recipients with chronic GVHD (6 out of 48). QTF-GIT indeterminate results were detected in 2.4% of the HSCT candidates. Fair to good agreement (K > 0.50) between tests was observed in both cohorts. Cumulative incidence of TB was 3% in the GVHD cohort. TB was diagnosed in 2 chronic GVHD recipients, both cases confirmed by positive culture and PCR. None of the 11 patients with LTBI diagnosed pre-HSCT who received INH prophylaxis developed TB.
- COVID-19 in HSCT recipients: a collaborative study of the Brazilian Society of Marrow Transplantation (SBTMO)(2022) DAUDT, Liane Esteves; CORSO, Mariana Cristina Moraes; KERBAUY, Mariana Nassif; ASSIS, Luiz Henrique dos Santos de; RECHENMACHER, Ciliana; COLTURATO, Iago; BARBIERI, Fernanda Rodrigues; ROCHA, Vanderson; MARIANO, Livia; GARCIA, Julia Lopes; DANTAS, Vanessa Esther Cavalcanti Barreto; LOTH, Gisele; FUNKE, Vaneuza Araujo Moreira; PELEGRINA, Polliany Roberta Dorini; DUARTE, Fernando Barroso; SILVA, Roberto Luiz da; ARAUJO, Marco Aurelio Salvino; CARLESSE, Fabianne Altruda de Moraes Costa; SOUSA, Ana Virginia Lopes de; MAIA, Luana Azevedo; FERNANDES, Juliana Folloni; RODRIGUES, Celso Arrais; BONFIM, Carmem; MARTINS, Leticia Navarro Gordan Ferreira; CIPOLOTTI, Rosana; XAVIER, Erick Menezes; GOMES, Alessandra Araujo; MORALES, Hugo Manuel Paz; SIMIONI, Anderson J.; SOARES, Victor Jablonski; MICHALOWSKI, Mariana Bohns; HAMERSCHLAK, Nelson; MACHADO, Clarisse MartinsIn the COVID-19 scenario, patients undergoing hematopoietic stem cell transplantation (HSCT) infected with SARS-CoV-2 may have an increased risk of death. Through a national multicenter study, we aimed to describe the impact of COVID-19 on the survival of HSCT recipients in Brazil. Eighty-six patients with a confirmed diagnosis of SARS-CoV-2 (92% by RT-PCR) were included. There were 24 children and 62 adults receiving an autologous (n = 25) and allogeneic (n = 61) HSCT for malignant (n = 72) and non-malignant (n = 14) disorders. Twenty-six patients died, (10 on autologous (38%) and 16 patients (62%) on allogeneic group). The estimated overall survival (OS) at day 40 was 69%. Adults had decreased OS compared to children (66% vs 79%, p = 0.03). The severity of symptoms at the time of diagnosis, ECOG score, laboratory tests (C-reactive protein, urea values) were higher in patients who died (p < 0.05). In conclusion, HSCT recipients infected with SARS-CoV-2 have a high mortality rate mainly in adults and patients with critical initial COVID-19 presentation. These findings show the fragility of HSCT recipients with SARS-CoV-2 infection. Therefore, the importance of adherence to preventive measures is evident, in addition to prioritizing the vaccination of family members and the HSCT team.