ROGERIO DE SOUZA
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Cardio-Pneumologia, Faculdade de Medicina - Docente
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina - Líder
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina - Líder
36 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 36
- Do Parameters of Cardiac Function Predict Long-term Outcomes in Patients With Pulmonary Arterial Hypertension? Data From SERAPHIN, a Randomized Controlled Study of Macitentan(2013) CHANNICK, Richard; DELCROIX, Marion; GALIE, Nazzareno; GHOFRANI, Hossein A.; JANSA, Pavel; BRUN, Franck-Olivier Le; MEHTA, Sanjay; PERCHENET, Loic; PULIDO, Tomas; SASTRY, B. K.; SITBON, Olivier; SOUZA, Rogerio; TORBICKI, Adam; RUBIN, Lewis J.; SIMONNEAU, Gerald
conferenceObject Echocardiographic Predictors of Mortality in Acute Decompensated Pulmonary Hypertension in the ICU(2019) MACEDO, B. R.; GARCIA, M.; SOUZA, R.; CARUSO, P.- Mechanisms of Exercise Limitation and Prevalence of Pulmonary Hypertension in Pulmonary Langerhans Cell Histiocytosis(2020) HEIDEN, Glaucia Itamaro; SOBRAL, Juliana Barbosa; FREITAS, Carolina Salim Goncalves; ALBUQUERQUE, Andre Luis Pereira de; SALGE, Joao Marcos; KAIRALLA, Ronaldo Adib; FERNANDES, Caio Julio Cesar dos Santos; CARVALHO, Carlos Roberto Ribeiro; SOUZA, Rogerio; BALDI, Bruno GuedesBACKGROUND: Pulmonary Langerhans cell histiocytosis (PLCH) determines reduced exercise capacity. The speculated mechanisms of exercise impairment in PLCH are ventilatory and cardiocirculatory limitations, including pulmonary hypertension (PH). RESEARCH QUESTION: What are the mechanisms of exercise limitation, the exercise capacity , and the prevalence of dynamic hyperinflation (DH) and PH in PLCH? STUDY DESIGN AND METHODS: In a cross-sectional study, patients with PLCH underwent an incremental treadmill cardiopulmonary exercise test with an evaluation of DH, pulmonary function tests, and transthoracic echocardiography. Those patients with lung diffusing capacity for carbon monoxide (D-LCO) < 40% predicted and/or transthoracic echocardiogram with tricuspid regurgitation velocity > 2.5 m/s and/or with indirect PH signs underwent right heart catheterization. RESULTS: Thirty-five patients were included (68% women; mean age, 47 +/- 11 years). Ventilatory and cardiocirculatory limitations, impairment suggestive of PH, and impaired gas exchange occurred in 88%, 67%, 29%, and 88% of patients, respectively. The limitation was multifactorial in 71%, exercise capacity was reduced in 71%, and DH occurred in 68% of patients. FEV1 and D-LCO were 64 +/- 22% predicted and 56 +/- 21% predicted. Reduction in D-LCO, an obstructive pattern, and air trapping occurred in 80%, 77%, and 37% of patients. FEV1 and D-LCO were good predictors of exercise capacity. The prevalence of PH was 41%, predominantly with a precapillary pattern, and mean pulmonary artery pressure correlated best with FEV1 and tricuspid regurgitation velocity. INTERPRETATION: PH is frequent and exercise impairment is common and multifactorial in PLCH. The most prevalent mechanisms are ventilatory, cardiocirculatory, and suggestive of PH limitations.
conferenceObject Cavities Lesions In Patients With Chronic Thromboembolic Pulmonary Hypertention(2017) OLIVEIRA, E. P.; FERNANDES, C. C.; OLEAS, F. G.; ALVES JUNIOR, J. L.; ATHANAZIO, R. A.; SALES, R. K. B.; MORAIS, I. O.; SALIBE FILHO, W.; JARDIM, C. V. P.; TERRA FILHO, M.; SOUZA, R.- A global view of pulmonary hypertension(2016) HOEPER, Marius M.; HUMBERT, Marc; SOUZA, Rogerio; IDREES, Majdy; KAWUT, Steven M.; SLIWA-HAHNLE, Karen; JING, Zhi-Cheng; GIBBS, J. Simon R.Pulmonary hypertension is a substantial global health issue. All age groups are affected with rapidly growing importance in elderly people, particularly in countries with ageing populations. Present estimates suggest a pulmonary hypertension prevalence of about 1% of the global population, which increases up to 10% in individuals aged more than 65 years. In almost all parts of the world, left-sided heart and lung diseases have become the most frequent causes of pulmonary hypertension. About 80% of affected patients live in developing countries, where pulmonary hypertension is frequently associated with congenital heart disease and various infectious disorders, including schistosomiasis, HIV, and rheumatic heart disease. These forms of pulmonary hypertension occur predominantly in those younger than 65 years. Independently of the underlying disease, the development of pulmonary hypertension is associated with clinical deterioration and a substantially increased mortality risk. Global research efforts are needed to establish preventive strategies and treatments for the various types of pulmonary hypertension.
conferenceObject Cardiovascular Magnetic Resonance Imaging In Newly Diagnosed, Treatment Naive Precapillary Pulmonary Hypertension(2014) HOETTE, S.; CREUZE, N.; MONTANI, D.; GUNTHER, S.; TERNACLE, J.; SIMONNEAU, G.; SOUZA, R.; HUMBERT, M.; CHEMLA, D.conferenceObject PULSAR Study Open-Label Extension: Interim Results from a Phase 2 Study of the Efficacy and Safety of Sotatercept When Added to Standard of Care for the Treatment of Pulmonary Arterial Hypertension (PAH)(2021) BADESCH, D. B.; GIBBS, S.; GOMBERG-MAITLAND, M.; HOEPER, M. M.; MCLAUGHLIN, V. V.; PRESTON, I; SOUZA, R.; WAXMAN, A. B.; MANIMARAN, S.; BARNES, J.; PENA, J. de Oliveira; HUMBERT, M.conferenceObject Right Ventricular Function Is Related To Resistive Rather Than To Elastic Pulmonary Arterial Properties In Precapillary Pulmonary Hypertension: A Cmr Study(2014) CREUZE, N.; HOETTE, S.; MONTANI, D.; GUNTHER, S.; GIRED, B.; SIMONNEAU, G.; SOUZA, R.; HUMBERT, M. J. C.; CHEMLA, D.conferenceObject - Macitentan Improves Health- Related Quality of Life for Patients With Pulmonary Arterial Hypertension(2017) MEHTA, Sanjay; SASTRY, Bhagavatula Kutumba Srinivasa; SOUZA, Rogerio; TORBICKI, Adam; GHOFRANI, Hossein-Ardeschir; CHANNICK, Richard N.; DELCROIX, Marion; PULIDO, Tomas; SIMONNEAU, Gerald; WLODARCZYK, John; RUBIN, Lewis J.; JANSA, Pavel; HUNSCHE, Elke; GALIE, Nazzareno; PERCHENET, Loic; SITBON, OlivierBACKGROUND: Pulmonary arterial hypertension (PAH) leads to reduced health-related quality of life (HRQoL). The objectives of this analysis were to evaluate the effect of macitentan on HRQoL in patients with PAH in the Study with an Endothelin Receptor Antagonist in Pulmonary Arterial Hypertension to Improve Clinical Outcome (SERAPHIN) study. The association between baseline HRQoL and long-term outcomes was also investigated. METHODS: Patients were randomized to placebo, macitentan 3 mg, or macitentan 10 mg once daily. Patients aged 14 years or older completed the 36-Item Short Form Survey (SF-36) at baseline, at month 6 and month 12, and at the end of treatment (EOT). The absolute change from baseline to month 6 in SF-36 scores was calculated. The time to a clinically meaningful deterioration in the SF-36 physical component summary and mental component summary (PCS and MCS) scores and associations between baseline PCS/MCS scores and time to morbidity/mortality events were also assessed. RESULTS: At month 6, macitentan 10 mg significantly improved seven of eight SF-36 domains and the PCS and MCS scores vs placebo. Macitentan 10 mg significantly reduced the risk of a three-point or greater deterioration in PCS (hazard ratio [HR], 0.60; 95% CI, 0.47- 0.76; P <.0001) and MCS scores (HR, 0.76; 95% CI, 0.61- 0.95; P = .0173) until EOT vs placebo. Patients with a baseline PCS score greater than the median baseline value had a significantly reduced risk of morbidity/mortality compared with patients with a PCS score less than the median; a similar result was observed for the MCS score. CONCLUSIONS: Macitentan significantly improved HRQoL in patients with PAH compared with placebo and significantly reduced the risk of a clinically meaningful HRQoL deterioration. An association between better baseline HRQoL and improved long-term outcomes was shown.