MIGUEL LUIZ ANTONIO MODOLIN
Índice h a partir de 2011
6
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
4 resultados
Resultados de Busca
Agora exibindo 1 - 4 de 4
- Cirurgias plásticas para readequação de contorno corporal de pacientes submetidos a cirurgia bariátrica durante a adolescência(2012) ROCHA, Rodrigo Itocazo; GEMPERLI, Rolf; MODOLIN, Miguel Luiz Antonio; CINTRA JUNIOR, Wilson; VELHOTE, Manoel Carlos Prieto; FERREIRA, Marcus CastroBACKGROUND: Surgical treatments for obesity in adolescents were introduced in the 1990s, resulting in individuals undergoing bariatric surgery, and exhibiting weight loss and dysmorphic body features. This produced a demand for plastic surgery in order to readjust the body contour. The aim of this study was to identify factors associated with morbidity and mortality for these corrective body contouring plastic surgeries in patients who underwent bariatric surgery during adolescence. METHODS: Between January 2008 and January 2011, 5 adolescent patients underwent gastric bypass surgery, with a consequent loss and stabilization of weight, and then underwent plastic surgery for correcting body contours. The average age of the patients at the time of plastic surgery was 19.7 years; 3 (60%) patients were female. Abdominoplasty was performed in all patients (100%), crural dermolipectomy in 4 (80%) patients, brachial dermolipectomy in 2 (40%) patients, thoracoplasty in 2 (40%) patients, torsoplasty in 2 (40%) patients, and a reverse abdominoplasty in 1 (20%) patient. In addition, mammoplasty with inclusion of silicone implants was performed in 2 (40%) female patients, whereas the other female patient (20%) underwent mastopexy. A male patient (20%) underwent correction of gynecomastia. An average of 3 surgical interventions were performed on each patient (range, 2 - 5), and the number of surgical sites was 20. RESULTS: Dehiscence occurred in 3 (15% of the surgical sites) cases, and it was necessary to revise the resection because of residual skin laxity in 3 (15% of the surgical sites) patients. CONCLUSIONS: Some factors associated with body contouring plastic surgeries in adolescents were identified and compared with the literature data.
- Prospective study of inflammatory response in patients submitted to abdominoplasty after bariatric surgery [Estudo prospectivo da reposta inflamatória em pacientes submetidas à abdominoplastia pós-cirurgia bariátrica](2021) GIULIANI, N. D. R.; MODOLIN, M.; JUNIOR, W. C.; ROCHA, R. I.; GEMPERLI, R.Introduction: Obesity is a chronic inflammatory disease associated with changes in inflammatory markers such as interleukins and CRP. This study evaluates the inflammatory response, through variations in interleukins and CRP, in patients undergoing abdominoplasty. Methods: Fourteen patients underwent abdominoplasty after weight loss achieved through bariatric surgery to maintain weight loss for at least18 months. Il4, IL6, IL10 and PCR levels were verified at times: preoperative, during surgery, 24 hours after surgery, 7th postoperative day and 14th postoperative day. Results: IL4 increased in the 24 hours postoperatively and continued on the rise until the 14th day. IL10 went up during surgery and began to fall in the 24 hours postoperatively to levels lower than the initial ones. IL6 began to rise during surgery, being more expressive in the 24 hours postoperatively, followed by a fall until the 14th day. CRP increased 24 hours postoperatively and remained discharged until the 14th day. Conclusion: Abdominoplasty reduced the chronic inflammatory systemic condition. © 2021, Sociedade Brasileira de Cirurgia Plastica (SBCP). All rights reserved.
- Tratamento das dismorfias coxofemorais em pacientes ex-obesos(2012) CINTRA JUNIOR, Wilson; MODOLIN, Miguel; ROCHA, Rodrigo Itocazo; MULATTI, Sheila Carvajal; GEMPERLI, Rolf; FERREIRA, Marcus CastroBACKGROUND: Patients showing massive weight loss eventually develop excessive skin and fat in several body parts, including the lower extremities. Given the diversity of the localization, shape, and content of coxofemoral dysmorphia, this study proposes guidelines for planning and systematizing the treatment of each deformity. METHODS: Twenty-eight female patients who underwent thigh lifts and showed 3 types of deformities were assessed. The deformities encompassed the upper third of the thigh alone, the upper and middle thirds, or the entire medial aspect of the thighs. A specific technique was used for treating each type of deformity. Moreover, when necessary, suspension of the lateral thigh was combined with liposuction. Patient satisfaction with the surgical results was assessed by a graded questionnaire. Unexpected events, complications, and treatments were recorded. RESULTS: Mobility, hygiene, sexual performance, use of clothing, and scars were assessed as excellent (80.5%), good (14.5%), and regular (5%). CONCLUSIONS: Considering the broad heterogeneity of thigh dysmorphia in formerly obese patients, therapeutic guidelines correlating each type of deformity with a specific treatment are necessary.
- Extracellular matrix remodeling derangement in ex-obese patients(2017) PRIST, Iryna Hirata; SALLES, Alessandra Grassi; LIMA, Thais Martins de; MODOLIN, Miguel Luiz Antonio; GEMPERLI, Rolf; SOUZA, Heraldo PossoloA known consequence of the large weight loss after bariatric surgery is the appearance of large skinfolds, particularly in the abdomen region of the patients. The balance between the synthesis of extracellular matrix (ECM) components and their proteolysis, mainly by fibrinolytic systems and matrix metalloproteases (MMPs), may be disturbed in these patients. The causes underlying the deregulation of ECM remodeling that occurs in these patients are not, however, clear. We investigated molecular mechanisms responsible for this dysfunction of ECM remodeling process, comparing it to normal skin. Collagen types, MMP2 and MMP9 expression and activity, interleukins 1 beta (IL1 beta) and 6 (IL6), and transcription coactivator PGC-1 beta expression were analyzed in 16 patients. Ex-obese patients presented increased expression of collagen types III and IV mRNA, increased expression of MMP2, decreased expression and activity of MMP9, and increased expression of PGC-1 beta in the skin. Inflammation markers IL1 beta and IL6 mRNA were not different. We have demonstrated that obese patients with extensive weight loss after bariatric surgery have increased expression of PGC-1 beta in the skin, which can result in a decreased expression and activity of MMP9 and increased collagen types III and IV deposition. These molecular changes may contribute for the formation of saggy skinfolds observed in these patients and impair wound healing.