LISETE RIBEIRO TEIXEIRA
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Cardio-Pneumologia, Faculdade de Medicina - Docente
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina - Líder
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina - Líder
50 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 50
conferenceObject MODELING INFLAMMATORY MEDIATORS AND APOPTOSIS BY PLEURAL MESOTHELIAL CELLS EXPOSED TO TALC PARTICLES(2014) ACENCIO, Milena Marques Pagliarelli; TEIXEIRA, Lisete Ribeiro; CAPELOZZI, Vera Luiza; SILVA, Bruna Rocha; ALVARENGA, Vanessa Adelia; SILVA, Carlos Rocha; VARGAS, Francisco Suso; MARCHI, EvaldoconferenceObject Intrapleural Target Therapies (anti-VEGF And Anti-EGFR) Reduce Malignant Pleural Effusion And Morbidity In An Experimental Model(2016) TEIXEIRA, L. R.; ACENCIO, M. M. P.; ALVARENGA, V. A.; PUKA, J.; LEITE, H. F. Z.; MILSONI, P. F.; FERNEZLIAN, S. M.; SANTOS, A. B. G.; MEDEIROS, M. C. R.; MARCHI, E.; CAPELOZZI, V. L.- Monoclonal antibodies anti-TGF beta 1 and anti-VEGF inhibit the experimental pleurodesis induced by silver nitrate(2012) MARCHI, Evaldo; VARGAS, Francisco S.; TAKEMURA, Renan L.; ACENCIO, Milena M.; ANTONANGELO, Leila; TEIXEIRA, Lisete R.; LIGHT, Richard W.Background. The mechanisms underlying pleural inflammation and pleurodesis are poorly understood. We hypothesized that the cytokines transforming growth factor beta (TGF beta 1) and vascular endothelial growth factor (VEGF) play a major role in pleurodesis after intrapleural silver nitrate (SN) injection. Method. Forty rabbits received intrapleurally 0.5% SN alone or 0.5% SN + anti-TGF beta 1, anti-IL-8, or anti-VEGF. After 28 days, the animals were euthanized and macroscopic pleural adhesions, microscopic pleural fibrosis, and collagen deposition were analyzed for characterization of the degree of pleurodesis (scores 0-4). Results. Scores of pleural adhesions, pleural fibrosis, total collagen, and thin collagen fibers deposition after 28 days were significantly lower for 0.5% SN + anti-TGF beta 1 and 0.5% SN + anti-VEGF. Significant correlations were found between macroscopic adhesion and microscopic pleural fibrosis with total collagen and thin collagen fibers. Conclusions. We conclude that both TGF beta 1 and VEGF, but not IL-8, mediate the pleural inflammatory response and pleurodesis induced by SN.
conferenceObject Brazilian Analysis of Lent Score: Predicting the Survival Rate of Malignant Pleural Effusion(2023) COLARES, P. F.; RIVAS, J. Delgado; BELON, C. E. F.; ACENCIO, M. M. P.; SALES, R. K.; TEIXEIRA, L. R.- Tuberculous empyema: combined intrapleural therapy might be an alternative(2022) COLARES, Philippe de Figueiredo Braga; RIVAS, Jennifer Kiara Delgado; SCIORTINO, Amanda dos Santos; SALES, Roberta Karla Barbosa de; TEIXEIRA, Lisete Ribeiro
conferenceObject Production Of Inflammatory Mediators And Induction Of Apoptosis In Pleural Mesothelial Cells, Lung And Breast Cancer Cells Exposed To Talc Particles(2016) ACENCIO, M. M. P.; TEIXEIRA, L. R.; ALVARENGA, V. A.; SILVA, C. S. R.; SALES, R. K. B.; MARCHI, E.- Improvements in the 6-Min Walk Test and Spirometry Following Thoracentesis for Symptomatic Pleural Effusions(2011) CARTAXO, Ana Maria; VARGAS, Francisco S.; SALGE, Joao Marcos; MARCONDES, Bianca F.; GENOFRE, Eduardo H.; ANTONANGELO, Leila; MARCHI, Evaldo; TEIXEIRA, Lisete R.Background: Impairment in pulmonary capacity due to pleural effusion compromises daily activity. Removal of fluid improves symptoms, but the impact, especially on exercise capacity, has not been determined. Methods: Twenty-five patients with unilateral pleural effusion documented by chest radiograph were included. The 6-min walk test, Borg modified dyspnea score, FVC, and FEV, were analyzed before and 48 h after the removal of large pleural effusions. Results: The mean fluid removed was 1,564 +/- 695 mL. After the procedure, values of FVC, FEV and 6-min walk distance increased (P<.001), whereas dyspnea decreased (P<.001). Statistical correlations (P<.001) between 6-min walk distance and FVC (r=0.725) and between 6-min walk distance and FEV, (r=0.661) were observed. Correlations also were observed between the deltas (prethoracentesis X postthoracentesis) of the 6-min walk test and the percentage of FVC (r=0.450) and of FEV, (r=0.472) divided by the volume of fluid removed (P<.05). Conclusion: In addition to the improvement in lung function after thoracentesis, the benefits of fluid removal are more evident in situations of exertion, allowing better readaptation of patients to routine activities. CHEST 2011; 139(6):1424-1429
- Sleep in patients with large pleural effusion: impact of thoracentesis(2012) MARCONDES, Bianca Fernandes; VARGAS, Francisco; PASCHOAL, Fabio Henrique; CARTAXO, Ana Maria; TEIXEIRA, Lisete R.; GENOFRE, Eduardo Henrique; ONISHI, Roberto; SKOMRO, Robert; LORENZI-FILHO, GeraldoThis study aimed to evaluate the sleep quality and impact of thoracentesis on sleep in patients with a large pleural effusion. Patients with large unilateral pleural effusion were evaluated by the Pittsburgh Sleep Quality Index (PSQI) questionnaire and dyspnea Borg scale. Full polysomnography (PSG) was performed on the night before and 36 h after thoracentesis. We studied 19 patients, 11 males and 8 females, age 55 +/- 18 years and body mass index of 26 +/- 5 kg/m(2). The baseline sleep quality was poor (PSQI = 9.1 +/- 3.5). Thoracentesis removed 1.624 +/- 796 mL of pleural fluid and resulted in a significant decrease in dyspnea Borg scale (2.3 +/- 2.1 vs. 0.8 +/- 0.9, p < 0.001). The PSG before and after thoracentesis showed no significant change in apnea-hypopnea index and sleep time with oxygen saturation < 90%. There was a significant improvement in sleep efficiency (76% vs. 81%, p = 0.006), decrease percent sleep stage 1 (16% vs. 14%, p = 0.002), and a trend improvement in total sleep time (344 +/- 92 vs. 380 +/- 69 min, p = 0.056) and percentage of rapid eye movement sleep (15% vs. 20%, p = 0.053). No significant changes occurred in six patients that performed two consecutive PSG before thoracentesis. The improvement in sleep quality was not associated with the volume of pleural fluid withdrawn or changes in dyspnea. Patients with large pleural effusion have poor subjective and objective sleep quality that improves after thoracentesis.
conferenceObject Tuberculous Empyema: Combined Intrapleural Therapy Might Be an Alternative(2023) COLARES, P. F.; RIVAS, J. Delgado; SCIORTINO, A. D.; SAAVEDRA, N. Medina; SALES, R.; TEIXEIRA, L. R.- Selectins and Platelet-Derived Growth Factor (PDGF) in Schistosomiasis-Associated Pulmonary Hypertension(2014) LAPA, Monica; ACENCIO, Milena M. P.; FARIAS, Alberto Q.; TEIXEIRA, Lisete R.; FERNANDES, Caio J. C.; JARDIM, Carlos P.; TERRA-FILHO, MarioThe aim of this study was to evaluate the expression profiles of the relevant selectins and PDGF in schistosomiasis-associated pulmonary hypertension. Patients with three distinct clinical profiles were enrolled in the study: IPAH(n = 11), schistosomiasis-associated PH (Sch-PH))(n = 13), and schistosomiasis without PH (Sch) (n = 13). Healthy volunteers, were recruited as a control group(n = 13). Echocardiography was performed in all groups, and the PH patients underwent right heart catheterization. Plasma soluble adhesion molecules E- and P-Selectin, PDGF-AB, PDGF-BB were determined by ELISA. E-selectin was significantly increased in the IPAH group compared with the other groups [the control, Sch + PH and Sch groups) (p < 0.001) (Fig. 2)]. P-selectin was lower in Sch (20.2 + 8.9 x 103 pg/mL) as compared to the control, (43 16.8 x 103 pg/mL), IPAH (35.8 7.8 x 103 pg/mL), and Sch + PH (36.8 +/- A 15.7 x 103 pg/mL) (p = 0.005) groups. Serum PDGF-BB levels were higher in the control group (8.9 +/- A 4.8 x 103 pg/mL) compared with the IPAH (3.7 +/- A 2.17 x 103 pg/mL), Sch + PH (5.2 +/- A 3.7 x 103 pg/mL) and Sch (2.4 +/- A 1.7 x 103 pg/mL) groups (p < 0.05). PDGF-AB levels were also higher in the control group (25.6 +/- A 8.6 x 103 pg/mL), compared with the other three groups, being the Sch group the one with lower serum levels of this marker (11.4 +/- A 8.6 x 103 pg/mL) (p = 0.006). In conclusion, vascular inflammation in schistosomiasis, with or without PH, is different from IPAH suggesting distinct pathophysiological mechanisms associated with the development of pulmonary hypertension.