GILSON MASAHIRO MURATA
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Clínica Médica, Faculdade de Medicina
LIM/29 - Laboratório de Nefrologia Celular, Genética e Molecular, Hospital das Clínicas, Faculdade de Medicina
LIM/29 - Laboratório de Nefrologia Celular, Genética e Molecular, Hospital das Clínicas, Faculdade de Medicina
2 resultados
Resultados de Busca
Agora exibindo 1 - 2 de 2
- A probiotic has differential effects on allergic airway inflammation in A/J and C57BL/6 mice and is correlated with the gut microbiome (vol 9, 134, 2021)(2021) CASARO, Mateus B.; THOMAS, Andrew M.; MENDES, Eduardo; FUKUMORI, Claudio; RIBEIRO, Willian R.; OLIVEIRA, Fernando A.; CRISMA, Amanda R.; MURATA, Gilson M.; BIZZARRO, Bruna; SA-NUNES, Anderson; SETUBAL, Joao C.; MAYER, Marcia P. A.; MARTINS, Flaviano S.; VIEIRA, Angelica T.; ANTIORIO, Ana T. F. B.; TAVARES-DE-LIMA, Wothan; CAMARA, Niels O. S.; CURI, Rui; DIAS-NETO, Emmanuel; FERREIRA, Caroline M.
- A probiotic has differential effects on allergic airway inflammation in A/J and C57BL/6 mice and is correlated with the gut microbiome(2021) CASARO, Mateus B.; THOMAS, Andrew M.; MENDES, Eduardo; FUKUMORI, Claudio; RIBEIRO, Willian R.; OLIVEIRA, Fernando A.; CRISMA, Amanda R.; MURATA, Gilson M.; BIZZARRO, Bruna; SA-NUNES, Anderson; SETUBAL, Joao C.; MAYER, Marcia P. A.; MARTINS, Flaviano S.; VIEIRA, Angelica T.; ANTIORIO, Ana T. F. B.; TAVARES-DE-LIMA, Wothan; CAMARA, Niels O. S.; CURI, Rui; DIAS-NETO, Emmanuel; FERREIRA, Caroline M.The phenotypes of allergic airway diseases are influenced by the interplay between host genetics and the gut microbiota, which may be modulated by probiotics. We investigated the probiotic effects on allergic inflammation in NJ and C57BU6 mice. C57BU6 mice had increased gut microbiota diversity compared to NJ mice at baseline. Acetate producer probiotics differentially modulated and altered the genus abundance of specific bacteria, such as Akkermansia and Allistipes, in mouse strains. We induced airway inflammation followed by probiotic treatment and found that only A/J mice exhibited decreased inflammation, and the beneficial effects of probiotics in NJ mice were partially due to acetate production. To understand the relevance of microbial composition colonization in the development of allergic diseases, we implanted female C57BU6 mice with NJ embryos to naturally modulate the microbial composition of NJ mice, which increased gut microbiota diversity and reduced eosinophilic inflammation in A/J. These data demonstrate the central importance of microbiota to allergic phenotype severity.