FABIO ALBERTO CASTILLO BUSTAMANTE

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  • bookPart
    Injeção de Toxina Botulínica
    (2020) BRUNALDI, Vítor Ottoboni; BUSTAMANTE, Fabio Alberto Castillo
  • article 8 Citação(ões) na Scopus
  • article 33 Citação(ões) na Scopus
    Obesity Treatment with Botulinum Toxin-A Is Not Effective: a Systematic Review and Meta-Analysis
    (2017) BUSTAMANTE, Fabio; BRUNALDI, Vitor Ottoboni; BERNARDO, Wanderley Marques; MOURA, Diogo Turiani H. de; MOURA, Eduardo Turiani H. de; GALVAO, Manoel; SANTO, Marco Aurelio; MOURA, Eduardo Guimares H. de
    The effectiveness of gastric injections of botulinum toxin-A (BTA) as primary treatment for obesity is not well known since results in literature are discrepant. Hence, we aimed to systematically review and meta-analyze the available data to assess the real effect of BTA therapy. We searched MEDLINE, Embase, Cochrane, SCOPUS, EBSCO, LILACS, and BVS. We considered eligible only randomized controlled trials enrolling obese patients comparing BTA versus saline injections. Our initial search identified 8811 records. Six studies fulfilled eligibility criteria. After critical appraisal, two articles were excluded and we meta-analyzed the remainder. The mean difference for absolute weight loss and BMI reduction were 0.12 [CI 95%, - 1.14, 1.38] and - 0.06 [95% CI, - 0.92, 0.81], respectively. Therefore, we concluded that treatment of obesity with BTA is not effective.
  • article 0 Citação(ões) na Scopus
    Response to ""The Forgotten Fundus-Obesity Treatment with Botulinum Toxin-A Is Not Effective: a Systematic Review and Meta-Analysis""
    (2018) BRUNALDI, Vitor Ottoboni; BUSTAMANTE, Fabio; BERNARDO, Wanderley M.; MOURA, Eduardo G. H. de
  • article 32 Citação(ões) na Scopus
    EUS-Guided Intragastric Injection of Botulinum Toxin A in the Preoperative Treatment of Super-Obese Patients: a Randomized Clinical Trial
    (2019) MOURA, Eduardo Guimaraes Hourneaux de; RIBEIRO, Igor Braga; FRAZAO, Mariana Souza Varela; MESTIERI, Luiz Henrique Mazzonetto; MOURA, Diogo Turiani Hourneaux de; BO, Creusa Maria Roveri Dal; BRUNALDI, Vitor Ottoboni; MOURA, Eduardo Turiani Hourneaux de; NUNES, Gabriel Cairo; BUSTAMANTE, Fabio Alberto Castillo; GALVAO NETO, Manoel dos Passos; MATUGUMA, Sergio Eiji; BERNARDO, Wanderley Marques; SANTO, Marco Aurelio
    BackgroundObesity is a disease that is highly prevalent in Brazil, and the associated comorbidities represent a major global public health challenge. Botulinum toxin type A (BTX-A) is a potent neurotoxin and inhibitor of gastric smooth muscle activity. In theory, BTX-A administration should promote early satiety and weight loss because it delays gastric emptying by inhibiting acetylcholine-mediated peristalsis, which is primarily responsible for gastric motility. Because results in the literature are discrepant, the efficacy of intragastric injections of BTX-A as a primary treatment for obesity remains unknown. The objective of this prospective, double-blind, single-center randomized study was to evaluate the effects of endoscopic ultrasound-guided intragastric BTX-A injections, as a bridge to bariatric surgery, in super-obese patients.MethodsThirty-two super-obese patients were randomized to one of two groups: BTX-A, in which 200units of BTX-A were injected into the gastric antrum and body; and control, in which the same injections were performed with 0.9% saline. Weight, body mass index (BMI), and loss of excess weight were measured monthly over a 6-month period. Gastric emptying scintigraphy was performed before and after the procedure.ResultsThe patients in both groups showed significant weight loss over the course of the study (p<0.001). There were no statistically significant differences between the groups regarding weight loss, excess weight, total loss of excess weight, total weight loss, or change in BMI.ConclusionsIntragastric injection of BTX-A does not appear to be an effective method of achieving preoperative weight loss in super-obese patients.
  • bookPart
    O Papel da Endoscopia no Sobrepeso e na Obesidade: Toxina Botulínica
    (2017) BUSTAMANTE, Fábio Alberto Castillo; BRUNALDI, Vitor Ottoboni; MOURA, Diogo Turiani Hourneaux de; SOUZA, Thiago Ferreira de; MOURA, Eduardo Guimarães Hourneaux de
  • conferenceObject
    OBESITY TREATMENT WITH BOTULINUM TOXIN-A IS NOT EFFECTIVE: A SYSTEMATIC REVIEW AND META-ANALYSIS. Endoscopic and Percutaneous Interventional Procedures
    (2017) BUSTAMANTE, F.; BRUNALDI, V. O.; BERNARDO, W. M.; MOURA, D. T.; MOURA, E. T.; GALVAO, M.; SANTO, M. A.; MOURA, E. G.
  • article 5 Citação(ões) na Scopus
    SURGERY VERSUS ENDOSCOPIC THERAPIES FOR EARLY CANCER AND HIGH-GRADE DYSPLASIA IN THE ESOPHAGUS: a systematic review
    (2016) BUSTAMANTE, Fabio Alberto Castillo; HOURNEAUX DE MOURA, Eduardo Guimarães; BERNARDO, Wanderley; SALLUM, Rubens Antonio Aissar; IDE, Edson; BABA, Elisa
    ABSTRACT Background Esophageal cancer occurs as a local disease in 22% of cases, and a minority of this disease is limited to the mucosa or submucosa (early lesions). Endoscopic mucosal resection, endoscopic submucosal dissection, photodynamic therapy, laser therapy, and argon plasma coagulation have emerged as alternatives to surgical resection for early lesions. Objective The aim of this systematic review is to identify studies that statistically compare survival, disease-free survival, morbidity and mortality associated with the procedure, and mortality associated with cancer in the endoscopic versus surgical therapies. Data sources A systematic review using MEDLINE, COCHRANE, EMBASE, EBSCO, LILACS, Library University of Sao Paulo, BVS, and SCOPE. Study selection Randomized controlled trial, controlled clinical trial, clinical trial, and cohort study. Criteria - Studies that statistically compare survival, disease-free survival, morbidity and mortality associated with the procedure, and mortality associated with cancer in patients who underwent endoscopic and surgical therapy for early lesions of esophageal cancer. Data extraction Independent extraction of the articles by two authors using predefined data fields, including study quality indicators. Limitation Only retrosprospective cohort studies comparing the endoscopic and surgical therapies were recovered. Results The survival rates after 3 and 5 years were different and exhibited superiority with the surgical therapies over time. Endoscopy is superior in the control of mortality related to cancer with a high rate of disease recurrence. With regard to the comorbidity and the mortality associated with the procedure, endoscopy is superior. Conclusion There is no evidence from clinical trials. In this systematic review, surgical therapies showed superiority for survival, and endoscopic therapies showed superiority in the control of mortality related to cancer with a high rate of disease recurrence; also, for the comorbidity and the mortality associated with the procedure, endoscopy is superior. Prospective, controlled trials with large sample sizes are necessary to confirm the results of the current analysis.
  • article
    Endoscopic palliative treatment versus surgical bypass in malignant low bile duct obstruction: A systematic review and meta-analysis
    (2015) LIMA, Silvia Lucia Alves de; BUSTAMANTE, Fabio Alberto Castillo; MOURA, Eduardo Guimaraes Hourneaux de; BERNARDO, Wanderley Marques; ARTIFON, Everson Luiz de Almeida; CHAVES, Dalton Marques; FRANZINI, Tomazo Antonio Prince; FURUYA JUNIOR, Carlos Kiyoshi
    Aims: Despite technological advances, only about 20% of periampullary tumors are found to be resectable at the time of presentation. Biliary tree obstruction and consequent jaundice occur in 70-90% of those patients and has important consequences for a patient's quality of life. Relief of biliary tree obstruction is the main goal for treatment, and few options for palliative therapy of biliary tree obstruction can be performed, including surgical bypass, percutaneous stenting, and endoscopic stenting. Objective: The aim of the present study was to acquire and analyze data to compare the success of procedures, procedure-related complication, mortality in 30 days, recurrent-jaundice rates in endoscopic, and surgical palliative techniques. Methods: Two independent reviewers searched the following electronic databases: Medline, EMBASE, Cochrane, LILACS, BVS, SCOPE, and CINAHL (EBSCO). Inclusion criteria included studies involving patients with distal biliary obstruction due to periampullary tumors who underwent endoscopic therapy or a surgical procedure for palliation. Results: No differences were observed for success of procedures; differences were observed with better outcomes for endoscopy therapy with regards to mortality associated with procedure, complication associated with procedure, and mortality in 30 days. Also, differences were observed with better outcomes for surgery therapy for recurrent-jaundice. Conclusion: Endoscopic palliative drainage is associated with a lower rate in complication, mortality associated with procedure, and mortality in 30 days. Recurrent-jaundice analysis demonstrated an overall lower rate in surgical bypass procedures. No differences were found for the success of procedures.
  • article 12 Citação(ões) na Scopus
    Endoscopic-ultrasound versus percutaneous-guided celiac plexus block for chronic pancreatitis pain: A systematic review and meta-analysis
    (2015) NOBRE MOURA, Renata; HOURNEAUX DE MOURA, Eduardo Guimarães; MARQUES BERNARDO, Wanderley; OTOCH, Jose P; CASTILLO BUSTAMANTE, Fabio Alberto; VIEIRA ALBERS, Débora; RODELA SILVA, Gustavo Luis; MARQUES CHAVES, Dalton; DE ALMEIDA ARTIFON, Everson Luiz
    Background: Abdominal pain is present in the vast majority of patients with chronic pancreatitis, being frequently debilitating. Celiac plexus block (CPB) is an interventional technique that can be considered to provide a temporary pain relief. Objective: To estimate the effectiveness and safeness of endoscopic-ultrasound (EUS) comparing with percutaneous-guided CBP in patients with pancreatic pain. Methods: A systematic review of English and non-English articles using MEDLINE, EMBASE, LILACS and COCHRANE (via BVS). Study selection and data extraction: Only randomized control trials (RCT) comparing the beneficial and harmful effects of EUS and percutaneous-guided celiac plexus block for managing pancreatic pain were included. Data was extracted and analyzed on variables including pain relief and related procedure complications. Results: Two RCT met the inclusion criteria. Both studies assessed the primary outcome (reduction on pain score) and evaluated adverse effects. The drugs injected were the same; nevertheless percutaneous technique was guided by fluoroscopy in one study and by computer tomography (CT) in other. The results showed that the EUS-CPB group was more effective to reduce pain score after 4 weeks after the procedure, with risk of bias to do this affirmation. No statistical difference in pain relief at 1, 8 and 12 weeks and in complications rates. Conclusions: Based on this systematic review and meta-analysis, no statistically significant difference was noted in pain relief and complications for EUS and percutaneous - CPB.