FABIO ALBERTO CASTILLO BUSTAMANTE
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bookPart Injeção de Toxina Botulínica(2020) BRUNALDI, Vítor Ottoboni; BUSTAMANTE, Fabio Alberto Castillo- Obesity Treatment with Botulinum Toxin-A Is Not Effective: a Systematic Review and Meta-Analysis(2017) BUSTAMANTE, Fabio; BRUNALDI, Vitor Ottoboni; BERNARDO, Wanderley Marques; MOURA, Diogo Turiani H. de; MOURA, Eduardo Turiani H. de; GALVAO, Manoel; SANTO, Marco Aurelio; MOURA, Eduardo Guimares H. deThe effectiveness of gastric injections of botulinum toxin-A (BTA) as primary treatment for obesity is not well known since results in literature are discrepant. Hence, we aimed to systematically review and meta-analyze the available data to assess the real effect of BTA therapy. We searched MEDLINE, Embase, Cochrane, SCOPUS, EBSCO, LILACS, and BVS. We considered eligible only randomized controlled trials enrolling obese patients comparing BTA versus saline injections. Our initial search identified 8811 records. Six studies fulfilled eligibility criteria. After critical appraisal, two articles were excluded and we meta-analyzed the remainder. The mean difference for absolute weight loss and BMI reduction were 0.12 [CI 95%, - 1.14, 1.38] and - 0.06 [95% CI, - 0.92, 0.81], respectively. Therefore, we concluded that treatment of obesity with BTA is not effective.
- Response to ""The Forgotten Fundus-Obesity Treatment with Botulinum Toxin-A Is Not Effective: a Systematic Review and Meta-Analysis""(2018) BRUNALDI, Vitor Ottoboni; BUSTAMANTE, Fabio; BERNARDO, Wanderley M.; MOURA, Eduardo G. H. de
- EUS-Guided Intragastric Injection of Botulinum Toxin A in the Preoperative Treatment of Super-Obese Patients: a Randomized Clinical Trial(2019) MOURA, Eduardo Guimaraes Hourneaux de; RIBEIRO, Igor Braga; FRAZAO, Mariana Souza Varela; MESTIERI, Luiz Henrique Mazzonetto; MOURA, Diogo Turiani Hourneaux de; BO, Creusa Maria Roveri Dal; BRUNALDI, Vitor Ottoboni; MOURA, Eduardo Turiani Hourneaux de; NUNES, Gabriel Cairo; BUSTAMANTE, Fabio Alberto Castillo; GALVAO NETO, Manoel dos Passos; MATUGUMA, Sergio Eiji; BERNARDO, Wanderley Marques; SANTO, Marco AurelioBackgroundObesity is a disease that is highly prevalent in Brazil, and the associated comorbidities represent a major global public health challenge. Botulinum toxin type A (BTX-A) is a potent neurotoxin and inhibitor of gastric smooth muscle activity. In theory, BTX-A administration should promote early satiety and weight loss because it delays gastric emptying by inhibiting acetylcholine-mediated peristalsis, which is primarily responsible for gastric motility. Because results in the literature are discrepant, the efficacy of intragastric injections of BTX-A as a primary treatment for obesity remains unknown. The objective of this prospective, double-blind, single-center randomized study was to evaluate the effects of endoscopic ultrasound-guided intragastric BTX-A injections, as a bridge to bariatric surgery, in super-obese patients.MethodsThirty-two super-obese patients were randomized to one of two groups: BTX-A, in which 200units of BTX-A were injected into the gastric antrum and body; and control, in which the same injections were performed with 0.9% saline. Weight, body mass index (BMI), and loss of excess weight were measured monthly over a 6-month period. Gastric emptying scintigraphy was performed before and after the procedure.ResultsThe patients in both groups showed significant weight loss over the course of the study (p<0.001). There were no statistically significant differences between the groups regarding weight loss, excess weight, total loss of excess weight, total weight loss, or change in BMI.ConclusionsIntragastric injection of BTX-A does not appear to be an effective method of achieving preoperative weight loss in super-obese patients.
bookPart O Papel da Endoscopia no Sobrepeso e na Obesidade: Toxina Botulínica(2017) BUSTAMANTE, Fábio Alberto Castillo; BRUNALDI, Vitor Ottoboni; MOURA, Diogo Turiani Hourneaux de; SOUZA, Thiago Ferreira de; MOURA, Eduardo Guimarães Hourneaux deconferenceObject OBESITY TREATMENT WITH BOTULINUM TOXIN-A IS NOT EFFECTIVE: A SYSTEMATIC REVIEW AND META-ANALYSIS. Endoscopic and Percutaneous Interventional Procedures(2017) BUSTAMANTE, F.; BRUNALDI, V. O.; BERNARDO, W. M.; MOURA, D. T.; MOURA, E. T.; GALVAO, M.; SANTO, M. A.; MOURA, E. G.