GUARACI DE LIMA REQUENA
Projetos de Pesquisa
Unidades Organizacionais
LIM/23 - Laboratório de Psicopatologia e Terapêutica Psiquiátrica, Hospital das Clínicas, Faculdade de Medicina
9 resultados
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conferenceObject Attentional Bias to Symmetry and Cleaning Features in Obsessive-Compulsive Disorder: A Pilot Study(2015) MATHIS, Maria Alice De; SALUM, Giovanni; MORAES, Ivanil; BATISTUZZO, Marcelo; MARCO, Marina De; TOLEDO, Maria Cecilia; REQUENA, Guaraci; ABEND, Rany; BAR-HAIM, Yair; MIGUEL, Euripedes; SHAVITT, Roseli- Intelligence quotient (IQ) in pediatric patients with obsessive-compulsive disorder(2020) BATISTUZZO, Marcelo Camargo; SOUZA, Marina de Marco e; BERNARDES, Elisa Teixeira; REQUENA, Guaraci; MIGUEL, Euripedes Constantino; SHAVITT, Roseli GedankeObjective: The aim of the present study was to examine the intellectual quotient (IQ) in a large sample of youth with obsessive-compulsive disorder (OCD) and to compare them with typically developing individuals (TDI), adding to the scarce literature focusing on the intelligence evaluation of this population. Method: The IQ of 82 children and adolescents with OCD and 82 TDI, matched by age, sex, handedness and education, was assessed by the Wechsler Abbreviated Scale of Intelligence (WASI, Brazilian-version). Statistics were performed with independent t-test, correlations and ANCOVA (controlling for motor and processing speed and comorbidities), corrected using the Benjamini-Hochberg multiple comparisons correction. Results: No between-group differences were found on the full-scale IQ (FSIQ, p-value = 0.545) or verbal IQ (VIQ; p-value = 0.423). In contrast, a significant difference was found in the performance IQ (PIQ; p-value = 0.045, Cohen's d = 0.379) and IQ discrepancy, i.e. the difference between VIQ and PIQ (p-value = 0.012, Cohen's d = 0.494). Analyses of the PIQ subtest scores revealed impaired performance in the Block Design test among OCD patients (p-value = 0.012, Cohen's d = 0.273), that remained after correcting for motor and processing speed and comorbidity status. Conclusion: In our sample of pediatric patients with OCD, the FSIQ, VIQ and PIQ were within the average range (90-110), and we did not find between-group differences in the FSIQ or VIQ, indicating that youth with OCD do not present major deficits in intellectual efficiency. Nevertheless, replicating an extensive adult literature, we found lower PIQ scores in youth patients, that were not better explained by motor and processing speed or comorbidity status.
conferenceObject Treatment Response Prediction in Pediatric Patients With OCD Using Structural Neuroimaging Correlates: Simple Linear Regression Versus Support Vector Regression(2017) VATTIMO, Edoardo; BARROS, Vivian; BATISTUZZO, Marcelo; REQUENA, Guaraci; SATO, Joao; FATORI, Daniel; SHAVITT, Roseli; MIGUEL, Euripedes; HOEXTER, MarceloconferenceObject Early Life Adverse Experiences and Obsessive-Compulsive Disorder: A Study With Patients, Siblings and Controls(2018) COSTA, Fabiana; CAPPI, Carolina; BATISTUZZO, Marcelo; SHAVITT, Roseli; REQUENA, Guaraci; MIGUEL, Euripedes; HOEXTER, Marcelo- Epigenetic evidence for involvement of the oxytocin receptor gene in obsessive-compulsive disorder(2016) CAPPI, Carolina; DINIZ, Juliana Belo; REQUENA, Guaraci L.; LOURENCO, Tiaya; LISBOA, Bianca Cristina Garcia; BATISTUZZO, Marcelo Camargo; MARQUES, Andrea H.; HOEXTER, Marcelo Q.; PEREIRA, Carlos A.; MIGUEL, Euripedes Constantino; BRENTANI, HelenaBackground: Obsessive-compulsive disorder (OCD) is a chronic neurodevelopmental disorder that affects up to 3% of the general population. Although epigenetic mechanisms play a role in neurodevelopment disorders, epigenetic pathways associated with OCD have rarely been investigated. Oxytocin is a neuropeptide involved in neurobehavioral functions. Oxytocin has been shown to be associated with the regulation of complex socio-cognitive processes such as attachment, social exploration, and social recognition, as well as anxiety and other stress-related behaviors. Oxytocin has also been linked to the pathophysiology of OCD, albeit inconsistently. The aim of this study was to investigate methylation in two targets sequences located in the exon III of the oxytocin receptor gene (OXTR), in OCD patients and healthy controls. We used bisulfite sequencing to quantify DNA methylation in peripheral blood samples collected from 42 OCD patients and 31 healthy controls. Results: We found that the level of methylation of the cytosine-phosphate-guanine sites in two targets sequences analyzed was greater in the OCD patients than in the controls. The higher methylation in the OCD patients correlated with OCD severity. We measured DNA methylation in the peripheral blood, which prevented us from drawing any conclusions about processes in the central nervous system. Conclusion: To our knowledge, this is the first study investigating DNA methylation of the OXTR in OCD. Further studies are needed to evaluate the roles that DNA methylation and oxytocin play in OCD.
- Obsessive-Compulsive Personality Symptoms Predict Poorer Response to Gamma Ventral Capsulotomy for Intractable OCD(2020) COPETTI, Maria Eugenia; LOPES, Antonio C.; REQUENA, Guaraci; JOHNSON, Isaac N. S.; GREENBERG, Benjamin D.; NOREN, Georg; MCLAUGHLIN, Nicole C. R.; SHAVITT, Roseli G.; MIGUEL, Euripedes C.; BATISTUZZO, Marcelo C.; HOEXTER, Marcelo Q.Gamma ventral capsulotomy (GVC) is a radiosurgical procedure which aims to create lesions in the ventral part of the anterior limb of the internal capsule (ALIC). It has been used as a treatment option for patients with intractable obsessive-compulsive disorder (OCD) who do not respond to several first-line treatments attempts. However, changes in personality disorder symptoms after GVC have not been investigated. The aims of this study are to investigate changes in personality disorder symptoms after GVC and to search for baseline personality disorder symptoms that may predict clinical response to GVC. Fourteen treatment-intractable OCD patients who underwent GVC completed the Structured Clinical Interview for DSM-IV Personality Disorders (SCID-II) at baseline and one year after the procedure. Wilcoxon signed-rank test was performed to investigate personality disorder symptom changes before and after surgery. Linear regression models were utilized to predict treatment response, using baseline personality disorder symptoms as independent variables. We did not observe any quantitative changes in personality disorder symptoms after GVC, compared with baseline. Higher severity of obsessive-compulsive personality disorder symptoms at baseline was correlated with worse treatment response after GVC for OCD (beta = -0.085, t-value = -2.52, p-value = 0.027). These findings advocate for the safety of the GVC procedure in this specific population of intractable OCD patients, in terms of personality disorder symptom changes. They also highlight the importance of taking into account the severity of obsessive-compulsive personality disorder symptoms when GVC is indicated for intractable OCD patients.
- Personality measures after gamma ventral capsulotomy in intractable OCD(2018) PAIVA, Raquel R.; BATISTUZZO, Marcelo C.; MCLAUGHLIN, Nicole C.; CANTERAS, Miguel M.; MATHIS, Maria E. de; REQUENA, Guaraci; SHAVITT, Roseli G.; GREENBERG, Benjamin D.; NOREN, Georg; RASMUSSEN, Steven A.; TAVARES, Hermano; MIGUEL, Euripedes C.; LOPES, Antonio C.; HOEXTER, Marcelo Q.Background: Neurosurgeries such as gamma ventral capsulotomy (GVC) are an option for otherwise intractable obsessive-compulsive disorder (OCD) patients. In general, clinical and neuropsychological status both improve after GVC. However, its consequences on personality traits are not well-studied. The objective of this study was to investigate personality changes after one year of GVC in intractable OCD patients. Methods: The personality assessment was conducted using the Revised NEO Personality Inventory (NEO PI-R) and Cloninger's Temperament and Character Inventory (TCI) in 14 intractable OCD patients before and one year after GVC. Comparisons of personality features between treatment responders (n = 5) and non-responders (n = 9) were performed. Multiple linear regression was also used for predicting changes in clinical and global functioning variables. Results: Overall, no deleterious effect was found in personality after GVC. Responders had a reduction in neuroticism (p = 0.043) and an increase in extraversion (p = 0.043). No significant changes were observed in nonresponders. Increases in novelty seeking and self-directedness, and decreases in persistence and cooperativiness predicted OCD symptom improvement. Similary, improvement in functioning was also predicted by hgher novelty seeking and self-directedness after GVC, whereas better functioning was also associated with lower reward dependence and cooperativeness after surgery. Conclusions: The pattern of changes in personality traits after GVC was generally towards that observed in nonclinical population, and does not raise safety concerns.
- Caudate volume differences among treatment responders, non-responders and controls in children with obsessive-compulsive disorder(2019) VATTIMO, Edoardo F. Q.; BARROS, Vivian B.; REQUENA, Guaraci; SATO, Joao R.; FATORI, Daniel; MIGUEL, Euripedes C.; SHAVITT, Roseli G.; HOEXTER, Marcelo Q.; BATISTUZZO, Marcelo C.Treatment response in obsessive-compulsive disorder (OCD) is heterogeneous and the neurobiological underpinnings of such variability are unknown. To investigate this issue, we looked for differences in brain structures possibly associated with treatment response in children with OCD. 29 children with OCD (7-17 years) and 28 age-matched controls underwent structural magnetic resonance imaging. Patients then received treatment with fluoxetine or group cognitive-behavioral therapy during 14 weeks, and were classified as treatment responders or non-responders. The caudate nucleus, thalamus and orbitofrontal cortex were selected a priori, according to previous evidence of their association with OCD and its treatment. Gray matter (GM) volume comparisons between responders, non-responders and controls were performed, controlling for total GM volume. 17 patients were classified as responders. Differences among responders, non-responders and controls were found in both caudate nuclei (both p-values=0.041), but after Bonferroni correction for multiple comparisons, these findings were non-significant. However, after excluding the effect of an outlier, findings were significant for the right caudate (p=0.004). Pairwise comparisons showed larger caudate GM volume in responders versus non-responders and controls, bilaterally. The right caudate accounted for 20.2% of the variance in Y-BOCS changes after treatment in a linear regression model, with a positive correlation (p=0.016). We present a possible neural substrate for treatment response in pediatric OCD, which is in line with previous evidence regarding the caudate nucleus. Considering the limitations, further research is needed to replicate this finding and elucidate the heterogeneity of treatment response in children with OCD.
- PREDICTING OBSESSIVE-COMPULSIVE DISORDER TREATMENT RESPONSE IN PEDIATRIC PATIENTS USING STRUCTURAL NEUROIMAGING CORRELATES: A COMPARISON BETWEEN SIMPLE LINEAR REGRESSION AND SUPPORT VECTOR REGRESSION(2016) VATTIMO, Edoardo F.; BARROS, Vivian B.; REQUENA, Guaraci; SATO, Joao R.; BATISTUZZO, Marcelo Camargo; SHAVITT, Roseli G.; FATORI, Daniel; MIGUEL, Euripedes; HOEXTER, Marcelo Q.