LUIZ HENRIQUE MAZZONETTO MESTIERI
Índice h a partir de 2011
5
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
2 resultados
Resultados de Busca
Agora exibindo 1 - 2 de 2
- EUS-Guided Intragastric Injection of Botulinum Toxin A in the Preoperative Treatment of Super-Obese Patients: a Randomized Clinical Trial(2019) MOURA, Eduardo Guimaraes Hourneaux de; RIBEIRO, Igor Braga; FRAZAO, Mariana Souza Varela; MESTIERI, Luiz Henrique Mazzonetto; MOURA, Diogo Turiani Hourneaux de; BO, Creusa Maria Roveri Dal; BRUNALDI, Vitor Ottoboni; MOURA, Eduardo Turiani Hourneaux de; NUNES, Gabriel Cairo; BUSTAMANTE, Fabio Alberto Castillo; GALVAO NETO, Manoel dos Passos; MATUGUMA, Sergio Eiji; BERNARDO, Wanderley Marques; SANTO, Marco AurelioBackgroundObesity is a disease that is highly prevalent in Brazil, and the associated comorbidities represent a major global public health challenge. Botulinum toxin type A (BTX-A) is a potent neurotoxin and inhibitor of gastric smooth muscle activity. In theory, BTX-A administration should promote early satiety and weight loss because it delays gastric emptying by inhibiting acetylcholine-mediated peristalsis, which is primarily responsible for gastric motility. Because results in the literature are discrepant, the efficacy of intragastric injections of BTX-A as a primary treatment for obesity remains unknown. The objective of this prospective, double-blind, single-center randomized study was to evaluate the effects of endoscopic ultrasound-guided intragastric BTX-A injections, as a bridge to bariatric surgery, in super-obese patients.MethodsThirty-two super-obese patients were randomized to one of two groups: BTX-A, in which 200units of BTX-A were injected into the gastric antrum and body; and control, in which the same injections were performed with 0.9% saline. Weight, body mass index (BMI), and loss of excess weight were measured monthly over a 6-month period. Gastric emptying scintigraphy was performed before and after the procedure.ResultsThe patients in both groups showed significant weight loss over the course of the study (p<0.001). There were no statistically significant differences between the groups regarding weight loss, excess weight, total loss of excess weight, total weight loss, or change in BMI.ConclusionsIntragastric injection of BTX-A does not appear to be an effective method of achieving preoperative weight loss in super-obese patients.
- IMPACT OF THE INTRAGASTRIC BALLOON ASSOCIATED WITH DIET ON THE TREATMENT OF DIABETIC PATIENTS WITH OVERWEIGHT OR GRADE I OBESITY AND ITS INFLUENCE ON THE PRODUCTION OF ENTEROHORMONES(2019) REIMAO, Silvia M.; SILVA, Maria Elizabeth R. da; NUNES, Gabriel C.; MESTIERI, Luiz H.; SANTOS, Rosa F. dos; MOURA, Eduardo G. de