MILTON ARTUR RUIZ
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conferenceObject ASSESSMENT OF LABILE PLASMA IRON IN PATIENTS SUBMITTED TO HEMATOPOIETIC STEM CELL TRANSPLANTATION(2013) NAOUM, Flavio; ESPOSITO, Breno; RUIZ, Lilian; RUIZ, Milton; TANAKA, Paula; PEREIRA, Juliana; CANCADO, Rodolfo; BARROS, Josearticle Bcl-2 protein in diffuse large B-cell lymphoma Response(2011) HALLACK NETO, Abrahao Elias; SIQUEIRA, Sheila Aparecida Coelho; DULLEY, Frederico Luiz; CHAUOBAH, Alfredo; BELESSO, Marcelo; SABOIA, Rosaura; RUIZ, Milton Artur; CHAMONE, Dalton Alencar Fischer; PEREIRA, Juliana- Is it time to use hematopoietic stem cell transplantation for severe and refractory crohn's disease?(2020) RUIZ, Milton Artur; KAISER JUNIOR, Roberto Luiz; QUADROS, Luiz Gustavo de
- T-cell large granular lymphocytic leukemia: treatment experience with fludarabine(2012) COSTA, Renata Oliveira; BELLESSO, Marcelo; CHAMONE, Dalton Alencar Fischer; RUIZ, Milton Artur; HALLACK NETO, Abrahao Elias; ALDRED, Vera Lucia; PEREIRA, JulianaOBJECTIVES: The aim of this retrospective study was to investigate the results of T-cell large granular lymphocytic leukemia treatment with fludarabine by assessing the complete hematologic response, the complete molecular response, progression-free survival, and overall survival. METHODS: We evaluated the records of six patients with T-cell large granular lymphocytic leukemia who were treated with fludarabine as a first-, second-, or third-line therapy, at a dose of 40 mg/m(2), for three to five days per month and 6 to 8 cycles. RESULTS: Of the six patients investigated with T-cell large granular lymphocytic leukemia who were treated with fludarabine, five (83.3%) were female, and their median age was 36.5 years (range 18 to 73). The median lymphocyte level was 3.4x10(9)/L (0.5 to 8.9). All patients exhibited a monoclonal T-cell receptor gamma gene rearrangement at diagnosis. Two (33.3%) patients received fludarabine as first-line treatment, two (33.3%) for refractory disease, one (16.6%) for relapsed disease after the suspension of methotrexate treatment due to liver toxicity, and one (16.6%) due to dyspesia. A complete hematologic response was achieved in all cases, and a complete molecular response was achieved in five out six cases (83.3%). During a mean follow-up period of 12 months, both the progression-free survival and overall survival rates were 100%. CONCLUSION: T-cell large granular lymphocytic leukemia demonstrated a high rate of complete hematologic and molecular response to fludarabine, with excellent compliance and tolerability rates. To confirm our results in this rare disease, we believe that fludarabine should be tested in clinical trials as a first-line treatment for T-cell large granular lymphocytic leukemia.
- The influence of hydroxyurea on oxidative stress in sickle cell anemia(2012) TORRES, Lidiane de Souza; SILVA, Danilo Grünig Humberto da; BELINI JUNIOR, Edis; ALMEIDA, Eduardo Alves de; LOBO, Clarisse Lopes de Castro; CANÇADO, Rodolfo Delfini; RUIZ, Milton Artur; BONINI-DOMINGOS, Claudia ReginaOBJECTIVE: The oxidative stress in 20 sickle cell anemia patients taking hydroxyurea and 13 sickle cell anemia patients who did not take hydroxyurea was compared with a control group of 96 individuals without any hemoglobinopathy. METHODS: Oxidative stress was assessed by thiobarbituric acid reactive species production, the Trolox-equivalent antioxidant capacity and plasma glutathione levels. RESULTS: Thiobarbituric acid reactive species values were higher in patients without specific medication, followed by patients taking hydroxyurea and the Control Group (p < 0.0001). The antioxidant capacity was higher in patients taking hydroxyurea and lower in the Control Group (p = 0.0002 for Trolox-equivalent antioxidant capacity and p < 0.0292 for plasma glutathione). Thiobarbituric acid reactive species levels were correlated with higher hemoglobin S levels (r = 0.55; p = 0.0040) and lower hemoglobin F concentrations(r = -0.52; p = 0.0067). On the other hand, plasma glutathione levels were negatively correlated with hemoglobin S levels (r = -0.49; p = 0.0111) and positively associated with hemoglobin F values (r = 0.56; p = 0.0031). CONCLUSION: Sickle cell anemia patients have high oxidative stress and, conversely, increased antioxidant activity. The increase in hemoglobin F levels provided by hydroxyurea and its antioxidant action may explain the reduction in lipid peroxidation and increased antioxidant defenses in these individuals.