SANDRA GOFINET PASOTO
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
LIM/03 - Laboratório de Medicina Laboratorial, Hospital das Clínicas, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
LIM/03 - Laboratório de Medicina Laboratorial, Hospital das Clínicas, Faculdade de Medicina
9 resultados
Resultados de Busca
Agora exibindo 1 - 9 de 9
bookPart Síndrome de Sjögren(2016) PASOTO, Sandra Gofinet; LOURENçO, Silvia Vanessa; PRADO, Leandro Lara do; GUEDES, Lissiane Karine NoronhabookPart Artrite(2016) PASOTO, Sandra Gofinet; MARTINS, Herlon SaraivaconferenceObject AGE-RELATED REFERENCE CURVES ADJUSTED TO WEIGHT AND HEIGHT OF VOLUMETRIC BONE DENSITY, STRUCTURE, AND BIOMECHANICAL PARAMETERS IN A POPULATION OF HEALTHY WOMEN: A HR-PQCT STUDY(2016) ALVARENGA, J.; FULLER, H.; PASOTO, S.; PEREIRA, R. M.bookPart Lúpus Eritematoso Sistêmico(2016) BORBA NETO, Eduaro Ferreira; SEGURO, Luciana Parente Costa; PASOTO, Sandra Gofinet; BONFá, Eloísa Silva Dutra de OliveirabookPart Avalicação Laboratorial das Doenças Reumatológicas(2016) VIANA, Vilma dos Santos Trindade; PASOTO, Sandra Gofinet; BONFá, Eloísa Silva Dutra de OliveirabookPart Autoimunidade(2016) PASOTO, Sandra Gofinet- Metabolic syndrome in Sjogren's syndrome patients: a relevant concern for clinical monitoring(2016) AUGUSTO, Kristopherson Lustosa; BONFA, Eloisa; PEREIRA, Rosa Maria Rodrigues; BUENO, Cleonice; LEON, Elaine Pires; VIANA, Vilma Santos Trindade; PASOTO, Sandra GofinetMetabolic syndrome (MetS) has been described in autoimmune diseases. However, there are scarce data about MetS and adipocytokine profile in primary Sjogren's syndrome (pSS). Seventy-one female pSS patients (American-European Consensus Group Criteria, 2002) aged 18-65 years and 71 age-, race-matched control women were enrolled in this case-control study. Clinical data were collected by a standardized protocol. Blood levels of glucose, cholesterol, low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), triglycerides, interleukin-1beta (IL-1beta)/IL-6, B-cell activating factor (BAFF), insulin, and leptin/adiponectin/visfatin/resistin were determined. Patients and controls were comparable regarding body mass index (BMI), smoking, sedentariness, and menopause (p > 0.05). MetS (39.4 vs. 16.9 %, p = 0.005), hypertension (p = 0.004), and dyslipidemia (p = 0.002) were more frequent in patients than controls. IL-1beta, IL-6, BAFF, resistin, and adiponectin levels were higher in patients than controls (p < 0.05). pSS patients with MetS (n = 28) had higher BMI, waist circumference, cholesterol, LDL-C, triglycerides, insulin, leptin and HOMA-IR values, and greater hypertension and diabetes rates than pSS patients without MetS (n = 43) (p < 0.05). Current and/or previous prednisone use (75.0 vs. 62.8 %, p = 0.313), current (3.0 +/- 4.5 vs. 1.6 +/- 3.2 mg/day, p = 0.299), and cumulative prednisone doses (p = 0.495) were similar in both groups. Otherwise, IL-1beta level was higher in MetS patients than in non-MetS patients (p = 0.012), and this finding was confirmed (p = 0.048) by multivariate analysis with adjustments for age, ethnicity, prednisone use, current and cumulative prednisone doses, and duration of use. We identified high MetS frequency and abnormal adipocytokine profile in pSS. The association of MetS with elevated IL-1beta level suggests that inflammation plays an important role in its pathogenesis.
- Cortical bone density and thickness alterations by high-resolution peripheral quantitative computed tomography: association with vertebral fractures in primary Sjogren's syndrome(2016) PASOTO, Sandra G.; AUGUSTO, Kristopherson L.; ALVARENGA, Jackeline C.; TAKAYAMA, Liliam; OLIVEIRA, Ricardo M.; BONFA, Eloisa; PEREIRA, Rosa M. R.Objectives. To evaluate volumetric BMD (vBMD), microarchitecture and strength and vertebral fractures (VFs) in primary SS (pSS). Methods. We evaluated 71 female pSS patients and 71 gender-, age-, and race-matched controls. Clinical data including risk factors for osteoporosis (OP) and fractures were collected through a standardized protocol. Areal BMD and VFs were analysed by DXA. Bone microarchitecture, vBMD and bone strength were assessed by high-resolution peripheral quantitative CT (HR-pQCT), a non-invasive method. Results. pSS patients and controls were comparable for age, BMI, calcium intake, smoking, menopause, sedentary lifestyle and family history of fractures (P > 0.05). OP or low BMD for the patient's age (33.8 vs 5.6%; P < 0.0001) and VFs (19.7 vs 5.6%; P = 0.043) were more frequent in patients than controls. HR-pQCT showed deterioration of cortical and trabecular components and strength at the radius, and of cortical components and strength at the tibia (P < 0.05) in patients compared with controls. pSS patients and controls were also analysed by multivariate analysis adjusted for age, ethnicity, prednisone use, weight and height, which showed that the pSS group had lower values of cortical vBMD, cortical thickness and apparent modulus (P < 0.05) at the radius and cortical vBMD and apparent modulus (P < 0.05) at the tibia. Patients with VFs had more cortical bone deterioration (cortical vBMD/cortical thickness) at the tibia compared with patients without VFs (P < 0.05). Conclusions. This study was the first to assess bone microarchitecture in pSS and demonstrated that cortical deterioration is the most important abnormality observed in pSS patients with VFs. This novel finding shows that this compartment contributes to vertebral fragility, suggesting that this non-invasive evaluation may be useful in the clinical practice.
conferenceObject Ultrasonography of Major Salivary Glands in Juvenile SjoGren's Syndrome - Preliminary Findings in a Multi-Center Study(2016) HAMMENFORS, Daniel S.; VALIM, Valeria; LILLEBY, Vibke; BICA, Blanca; PASOTO, Sandra Gofinet; SILVA, Clovis; NIETO, Juan Carlos; LIEBERMAN, Scott; THATAYATIKOM, Akaluck; JONSSON, Roland; BRUN, Johan G.; JONSSON, Malin V.