WHADY ARMINDO HUEB
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Cardio-Pneumologia, Faculdade de Medicina - Docente
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação, Hospital das Clínicas, Faculdade de Medicina
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação, Hospital das Clínicas, Faculdade de Medicina
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conferenceObject The Release of Cardiac Necrosis Biomarkers in Patients Without Myocardial Infarction After On-Pump Surgical Revascularization. A Study of Cardiac Magnetic Resonance Imaging(2016) OIKAWA, Fernando T.; HUEB, Whady; COSTA, Leandro M.; MELO, Rodrigo M. Vieira de; REZENDE, Paulo C.; GARZILLO, Cibele L.; LIMA, Eduardo G.; NOMURA, Cesar H.; VILLA, Alexandre V.; HUEB, Alexandre C.; RAMIRES, Jose A.; KALIL FILHO, RobertoconferenceObject Two-year Follow-up Of Patients With Chronic Ischemic Heart Disease In A Specialized Center In Brazil(2021) PINESI, Henrique Trombini; MOREIRA, Eduardo M.; BOLTA, Paula M.; MARTINS, Eduardo B.; PITTA, Fabio G.; REZENDE, Paulo C.; LIMA, Eduardo G.; HUEB, Whady; GARZILLO, Cibele L.; SERRANO, Carlos V.conferenceObject Lifestyle in wine drinkers and abstemious: the relationship of coronary lesions, calcium score and risk factors(2012) MOCHIDUKY, Roberta I.; ROCHITTE, Carlos E.; FAVARATO, Desiderio; ALBUQUERQUE, Cicero P.; GONSALVES, Cibele Regina L.; LAURINDO, Francisco Rafael M.; HUEB, Whady A.; LUZ, Protasio DaIntroduction: Red wine (RW) protects the cardiovascular system but objective evidence based on coronary status is lacking. Objectives: To assess the effects of chronic RW consumption upon coronary lesion burden. Methods: We performed Coronary Computed Tomographic Angiography in 204 male subjects whose mean age was 58.95±7.3 years and related lesions to risk factors (RF). One hundred were chronic RW drinkers who consumed at least one glass of RW wine/day, 4 –5 times/week, in the last 5 years and 104 were abstemious. Results: RW drinkers consumed 25.78 gr alcohol/day vs 0 among abstemious; they also ingested more calories (2118.50kcal vs 1776.21kcal daily; p<0.01) mainly from saturated fats (22.98 g vs16.51g; p<0.05) than abstemious. Abstemious, however, ingested more fibers (22.73 gr vs17.49 gr; p<0.05). There were no significant differences regarding age, smoking, BMI, arterial hypertension, diabetes, LDL and triglycerides. Psychological factors including anxiety, depression and stress also were similar. However, plasma glucose was lower (97.5±18.3 mg% vs105.9±32.0 mg %; p<0.06) and HDL was higher (46.9±10.9 mg% vs 39.5±9.0 mg%;p<0.01) in RW drinkers compared to abstemious. Calcium score was higher on RW drinkers than in abstemious(144.43±362.2 vs 122.05±370.26; p<0.004). Lesions were classified as absent or 50%. Considering LM, ADA, RCA and Cx in proximal, median and distal portions, plus 3 marginal, 3 diagonal and 2 terminal RCA branches, 3672 segments were included in the analysis. There were no significant differences regarding lesions severity between groups, except for more frequent zero lesions in proximal Cx (86.3 x 71.4 %; p<0.016). Conclusion: Despite higher caloric intake and saturated fats, RW drinkers have similar coronary lesion burden; calcium score, however, was higher compared to abstemious. Higher HDL cholesterol as cribed to RW drinking and lower plasma glucose may have protective roles.- Cost-Effectiveness Analysis for Surgical, Angioplasty, or Medical Therapeutics for Coronary Artery Disease 5-Year Follow-Up of Medicine, Angioplasty, or Surgery Study (MASS) II Trial(2012) VIEIRA, Ricardo D'Oliveira; HUEB, Whady; HLATKY, Mark; FAVARATO, Desiderio; REZENDE, Paulo Cury; GARZILLO, Cibele Larrosa; LIMA, Eduardo Gomes; SOARES, Paulo Rogerio; HUEB, Alexandre Ciappina; PEREIRA, Alexandre Costa; RAMIRES, Jose Antonio Franchini; KALIL FILHO, RobertoBackground-The Second Medicine, Angioplasty, or Surgery Study (MASS II) included patients with multivessel coronary artery disease and normal systolic ventricular function. Patients underwent coronary artery bypass graft surgery (CABG, n = 203), percutaneous coronary intervention (PCI, n = 205), or medical treatment alone (MT, n = 203). This investigation compares the economic outcome at 5-year follow-up of the 3 therapeutic strategies. Methods and Results-We analyzed cumulative costs during a 5-year follow-up period. To analyze the cost-effectiveness, adjustment was made on the cumulative costs for average event-free time and angina-free proportion. Respectively, for event-free survival and event plus angina-free survival, MT presented 3.79 quality-adjusted life-years and 2.07 quality-adjusted life-years; PCI presented 3.59 and 2.77 quality-adjusted life-years; and CABG demonstrated 4.4 and 2.81 quality-adjusted life-years. The event-free costs were $9071.00 for MT; $19 967.00 for PCI; and $18 263.00 for CABG. The paired comparison of the event-free costs showed that there was a significant difference favoring MT versus PCI (P<0.01) and versus CABG (P<0.01) and CABG versus PCI (P<0.01). The event-free plus angina-free costs were $16 553.00, $25 831.00, and $24 614.00, respectively. The paired comparison of the event-free plus angina-free costs showed that there was a significant difference favoring MT versus PCI (P=0.04), and versus CABG (P<0.001); there was no difference between CABG and PCI (P>0.05). Conclusions-In the long-term economic analysis, for the prevention of a composite primary end point, MT was more cost effective than CABG, and CABG was more cost-effective than PCI.
conferenceObject Expression of Ischemic Preconditioning in Patients With Stable Multivessel Coronary Artery Disease With and Without Diabetes Mellitus(2013) REZENDE, Paulo C.; GARCIA, Rosa M.; UCHIDA, Augusto H.; LIMA, Eduardo G.; GARZILLO, Cibele L.; SEGRE, Carlos A.; CESAR, Luiz A.; HUEB, Whady; RAMIRES, Jose A.; KALIL FILHO, RobertoconferenceObject Gender-related Differences in the Management of Chronic Coronary Syndrome: Registry Data of a Tertiary Center in Brazil(2020) SERRANO, Carlos V.; MOREIRA, Eduardo M.; GARZILLO, Cibele L.; MONTENEGRO, Luiz M.; TABUSE, Cindy L.; KORMANN-MOREIRA, Mylena C.; SEGRE, Alexandre W.; BOLTA, Paula M.; FAVARATO, Desiderio; PITTA, Fabio G.; LIMA, Eduardo G.; REZENDE, Paulo H.; HUEB, Whady A.conferenceObject Impact of Chronic Kidney Dysfunction Among Patients With Stable Coronary Artery Disease: Ten-Year Follow-Up of Mass II Trial(2016) LIMA, Eduardo G.; HUEB, Whady; GARZILLO, Cibele L.; FAVARATO, Desiderio; HUEB, Alexandre C.; REZENDE, Paulo C.; SILVA, Expedito E.; GARCIA, Rosa M.; SCUDELER, Thiago L.; RAMIRES, Jose A.; KALIL FILHO, RobertoconferenceObject Biomarkers Release After Percutaneous Coronary Intervention in Patients Without Definitive Miocardial Infarction Assessed by Cardiac Magnetic Ressonance With Late Gadolinium Enhancement. a Prospective Trial Using the Third Universal Definition of Myocardial Infarction(2014) MELO, Rodrigo M. Vieira de; OIKAWA, Fernando T.; COSTA, Leandro M.; REZENDE, Paulo C.; SCUDELER, Thiago L.; NOMURA, Cesar H.; VILLA, Alexandre V.; HUEB, Alexandre C.; HUEB, Whady; KALIL FILHO, RobertoconferenceObject Abnormal Release of Cardiac Biomarkers in the Presence of Myocardial Edema Evaluated by Cardiac Magnetic Resonance After Uncomplicated Revascularization Procedures(2018) RIBAS, Fernando F.; REZENDE, Paulo C.; BOROS, Gustavo A.; DALLAZEN, Anderson R.; LINHARES FILHO, Jaime P.; NOMURA, Cesar H.; ROCHITTE, Carlos E.; VILLA, Alexandre V.; LIMA, Eduardo G.; CARVALHO, Guilherme F.; HUEB, Whady; RAMIRES, Jose A.; KALIL FILHO, Roberto