DANIEL FUENTES MOREIRA
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conferenceObject Improvement of obsessive-compulsive symptoms after bilateral subthalamic stimulation in Parkinson's disease(2015) FONOFF, F. M. C.; FONOFF, E. T.; BARBOSA, E. R.; MACHADO, R. B.; CURY, R. G.; SANTOS, M. G. G. dos; TEIXEIRA, M. J.; FUENTES, D.- Mapping brain volumetric abnormalities in never-treated pathological gamblers(2015) FUENTES, Daniel; RZEZAK, Patricia; PEREIRA, Fabricio R.; MALLOY-DINIZ, Leandro F.; SANTOS, Luciana C.; DURAN, Fabio L. S.; BARREIROS, Maria A.; CASTRO, Claudio C.; BUSATTO, Geraldo F.; TAVARES, Hermano; GORENSTEIN, ClariceSeveral magnetic resonance imaging (MRI) studies to date have investigated brain abnormalities in association with the diagnosis of pathological gambling (PG), but very few of these have specifically searched for brain volume differences between PG patients and healthy volunteers (HV). To investigate brain volume differences between PG patients and HV, 30 male never treated PG patients (DSM-IV-TR criteria) and 30 closely matched HV without history of psychiatric disorders in the past 2 years underwent structural magnetic resonance imaging with a 1.5-T instrument. Using Freesurfer software, we performed an exploratory whole brain voxelwise volume comparison between the PG group and the HV group, with false discovery rate correction for multiple comparisons (p <0.05), Using a more flexible statistical threshold (p < 0.01, uncorrected for multiple comparisons), we also measured absolute and regional volumes of several brain structures separately. The voxelwise analysis showed no clusters of significant regional differences between the PG and HV groups. The additional analyses of absolute and regional brain volumes showed increased absolute global gray matter volumes in PG patients relative to the HV group, as well as relatively decreased volumes specifically in the left putamen, right thalamus and right hippocampus (corrected for total gray matter). Our findings indicate that structural brain abnormalities may contribute to the functional changes associated with the symptoms of PG, and they highlight the relevance of the brain reward system to the pathophysiology of this disorder.
- A naturalistic study of recovering gamblers: What gets better and when they get better(2015) ROSSINI-DIB, Danielle; FUENTES, Daniel; TAVARES, HermanoGambling recovery has typically been assessed through the lens of gambling behavior and its consequences. Little attention has been given to less obvious features of gambling disorder, such as negative affectivity, gambling cognitive distortions, impulsivity, cognitive flexibility, planning, inhibitory control, and decision-making. The current study investigates how gambling treatment affected these variables and if any are related to gambling recovery. One hundred and thirteen patients were assigned to psycho-education and psychiatric treatment. A subset of 48 patients was additionally assigned to cognitive behavioral therapy (CBT). Seventy-two patients were reassessed 6 months after treatment onset. Recovered and non-recovered gamblers did not differ in pre-treatment demographic, gambling, and psychiatric profiles. Three outcome variables were strongly related with gambling recovery: negative affectivity, cognitive distortions and decision-making. Logistic regression identified reduction of gambling cognitive distortions and better performance on decision-making as the best predictors of gambling recovery, regardless of the type of treatment received. Beyond the standard outcome measures for gambling treatment, increased sensitivity to loss and decreased positive expectancies towards gambling are key targets to promote recovery in gambling treatment.
- Correlation Between Impulsivity and Executive Function in Patients With Parkinson Disease Experiencing Depression and Anxiety Symptoms(2015) FONOFF, Fernanda Colucci; FONOFF, Erich Talamoni; BARBOSA, Egberto Reis; QUARANTA, Thais; MACHADO, Rachael Brant; ANDRADE, Daniel Ciampi de; TEIXEIRA, Manoel Jacobsen; FUENTES, DanielBackground:Depression and anxiety are comorbidities often associated with Parkinson disease (PD). Recent studies debate on how affective disorders can influence the cognition of patients with PD. This study sought to investigate how depression and anxiety affect specific executive functions and impulsivity traits in these patients. Methods:Twenty-eight patients with advanced PD and 28 closely matched healthy volunteers (HV) were assessed for depressive and anxiety symptoms, impulsivity, executive function and control attention and behavioral response. Results:Compared to the HV group, the PD group showed significantly higher perseverative responses and slowness to adapt to changes in environmental stimuli and longer reaction time for inter-stimulus interval change. Depression symptoms were significantly correlated to motor impulsivity score and total Barratt Impulsiveness Scale (BIS -11) score. Moreover, there was also significant correlation between anxiety symptoms and attentional impulsivity score and total BIS-11 score. Correlation analysis between impulsivity and control attention indicated a positive correlation in commission and a negative correlation in reaction time and detectability in the PD group. Conclusions:The present results suggest that depression and anxiety were highly correlated to impulsivity but not to executive functions changes in these PD patients.