CARLA GONCALVES SCHAHIN SAAD
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
12 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 12
conferenceObject PREDICTORS OF MORTALITY IN RA PATIENTS BEFORE THE ADVENT OF BIOLOGIC THERAPY(2018) ROSARIO, D. C.; BULHOES, C. N.; TOLEDO, R. P.; BONGLIOLI, K.; RIBEIRO, A. C. M.; MORAES, J. C. B.; SAAD, C. G. S.; SILVA, C. A.; BONFA, E.; AIKAWA, N. E.conferenceObject A CROSS-SECTIONAL EVALUATION OF A BRAZILIAN SPONDYLOARTHRITIS SINGLE-CENTER TERTIARY COHORT: CLINICAL AND TREATMENT DATA(2018) SHIMABUCO, A.; MORAES, J. C. B. de; SAMPAIO-BARROS, P.; GOLDENSTEIN-SCHAINBERG, C.; GONCALVES, C. R.; SAAD, C. G. S.conferenceObject PREVALENCE AND CHARACTERIZATION OF PSORIATIC ARTHRITIS MUTILANS PATIENTS FROM A SINGLE TERTIARY CENTER(2018) OLIVEIRA, J. L.; CORDEIRO, R. A.; CARRASCO, S.; GONCALVES, C. R.; MORAES, J. C. B.; SAAD, C. G. S.; SAMPAIO-BARROS, P. D.; GOLDENSTEIN-SCHAINBERG, C.conferenceObject Improvement of Cytological Grade and Tear Production in Ankylosing Spondylitis Patients Under Anti-TNF Therapy: A Long-Term Follow-up(2018) USUBA, Fany; SAAD, Carla G. S.; NOVAES, Priscila; SANTO, Ruth; MORAES, Julio C. B.; BONFA, Eloisa; ALVES, MiltonconferenceObject DISPENSATION OF IMMUNOBIOLOGICALS IN MODEL OF ASSISTED THERAPY IN THE SUS REDUCES COSTS WITH IMMUNOBIOLOGICAL IN ANKYLOSING SPONDYLITIS(2018) SCOMPARIN-SILVERIO, L. R.; SAAD, C. G. S.; SOUZA, F. H. C.; MIOSSI, R.; RIBEIRO, A. C. M.; WAISBERG, M. G.; BONFIGLIOLI, K. R.; PRADO, L. L.; TEICH, V; BONFA, E.; MORAES, J. C. B.- Factors associated with ASDAS remission in a long-term study of ankylosing spondylitis patients under tumor necrosis factor inhibitors(2018) SHIMABUCO, Andrea Y.; GONCALVES, Celio R.; MORAES, Julio C. B.; WAISBERG, Mariana G.; RIBEIRO, Ana Cristina de M.; SAMPAIO-BARROS, Percival D.; GOLDENSTEIN-SCHAINBERG, Claudia; BONFA, Eloisa; SAAD, Carla G. S.Objective: To determine the clinical and demographic factors associated with disease remission and drug survival in patients with ankylosing spondylitis (AS) on TNF inhibitors. Methods: Data from a longitudinal electronic database of AS patients under anti-TNF therapy between June/2004 and August/2013. Demographic, clinical parameters, disease activity by ASDAS remission (< 1.3) and inactive/low (< 2.1) were analyzed to characterize reasons for drug survival and switching of anti-TNF. Results: Among 117 AS patients, 69 (59%) were prescribed only one anti-TNF, 48 (41%) switched to a second anti-TNF and 13 (11%) to a third anti-TNF. Considering ASDAS-CRP < 1.3, 31 (39%) patients were inactive at the end of the study. Non-switchers (P = 0.04), younger age (P = 0.004), non-smoking (P = 0.016), shorter disease duration (P = 0.047), more frequent use of SSZ (P = 0.037) and lower BASDAI (P = 0.027), BASMI (P = 0.034) and BASFI (P = 0.003) at baseline were associated with remission. In the multivariate analysis younger age (P = 0.016) and lower BASDAI (P = 0.032) remained as remission predictors. Conclusion: This study supports that ASDAS-CRP remission is an achievable goal not only for non-switchers but also for second anti-TNF, particularly in patients with younger age and lower BASDAI at baseline. Co-medication and non-smoker status seems to have a beneficial effect in anti-TNF response in this population.
article 6 Citação(ões) na Scopus Anti-alpha-enolase antibodies in Behcet's disease: a marker of mucocutaneous and articular disease activity?(2018) PRADO, L. L.; GONCALVES, C. R.; VIANA, V. T.; SAAD, C. G. S.; BONFA, E.Objective. To assess IgM anti-alphaenolase antibodies (AAEA) in systemic Behget's disease (BD) and its possible association with clinical manifestations and disease activity. Methods. Ninety-seven consecutively selected BD patients were compared to 36 enteropathic spondyloarthritis (ESpA) [24 Crohn's disease (CD) and 12 ulcerative colitis (UC)] patients and 87 healthy controls. 1gM AAEA was detected by immunoblotting. Disease activity was assessed by standardised indexes, Brazilian BD Current Activity Form (BR-BDCAF) for BD and HarveyBradshaw Index (HBI) for CD and UC patients. A second evaluation was performed in BD patients (n=56), regarding IgM AAEA presence, disease activity scores and C-reactive protein (CRP). Results. Higher IgM AAEA prevalence was found in 97 BD (17.7%) compared to ESpA (2.8%) and healthy controls (2.3%), p< O. O01. IgM AAEA frequency was higher in active BD compared to inactive BD (30.2% vs. 7.4%, p=O. O06), a finding confirmed in the second cross-sectional evaluation of 56 of these BD patients (45.5% vs. 13.3%, p=O. 02). Mean BR-BDCAF scores were higher in IgM AAEA positive group on both evaluations (9.1 + 5.4 vs. 4.9 + 4.9, p=O. O02; 5.0 + 4.9 vs. 2.2 + 2.9, p=O. 01, respectively). BD patients with mucocutaneous and articular symptoms presented higher IgM AAEA positivity in the first and second evaluations (64.7% vs. 27.5%, p=O. O05; 36.4% vs. 7.1%, p=0.039 respectively). Conclusions. Our data support the notion that alpha-enolase is a target antigen in BD, particularly associated with disease activity, mucocutaneous and articular involvement. In addition, IgM AAEA may distinguish BD from ESpA, especially in patients with high disease activity.conferenceObject IMPROVEMENT OF CYTOLOGICAL GRADE AND TEAR PRODUCTION IN ANKYLOSING SPONDYLITIS PATIENTS UNDER ANTI-TNF THERAPY: A LONG-TERM FOLLOW-UP(2018) USUBA, F. S.; SAAD, C. G. S.; NOVAES, P.; SANTO, R. M.; MORAES, J. C. B.; BONFA, E.; ALVES, M. R.conferenceObject Real Life Analysis of a Latin America Tertiary Spondyloarthritis Single-Center: High Frequency of Peripheral Involvement and Use of Synthetic Dmard(2018) SHIMABUCO, Andrea; MORAES, Julio C. B.; SAMPAIO-BARROS, Percival; GOLDENSTEIN-SCHAINBERG, Claudia; GONCALVES, Celio R.; RIBEIRO, Ana C. M.; SAAD, Carla G. S.bookPart Espondiloartrites(2018) SAAD, Carla Gonçalves Schahin; MORAES, Júlio César Bertacini de; GOLDENSTEIN-SCHAINBERG, Cláudia; BARROS-SAMPAIO, Percival Degrava; GONçALVES, Célio Roberto